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Nasal drops for treating rhinitis and preparation method thereof

A technology for nasal drops and rhinitis, which is applied in the field of nasal drops for treating rhinitis and its preparation, can solve the problems of short drug action time, large toxic and side effects, and single pharmacological action, so as to improve nasal mucosa congestion, facilitate industrial production, The effect of broad application prospects

Pending Publication Date: 2019-04-05
江西润泽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the medicines for treating rhinitis clinically mainly include oral medicines, injections, patches, sprays and drops; during the absorption and distribution process of systemic medicines such as oral or injection, some medicines are destroyed by the gastrointestinal tract and liver or shunted by blood circulation. The effective concentration reaching the lesion in the nasal cavity is very low, it is difficult to achieve the therapeutic effect, and it can induce drug resistance of bacteria and make the lesion become chronic, so the curative effect is poor and the cure rate is low; the drops can directly drop the drug on the lesion, and have a good effect on the disease. Lesions are treated, but the existing drops for the treatment of rhinitis only have the ability to constrict blood vessels and improve the nasal congestion symptoms caused by rhinitis. drug-induced rhinitis

Method used

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  • Nasal drops for treating rhinitis and preparation method thereof
  • Nasal drops for treating rhinitis and preparation method thereof
  • Nasal drops for treating rhinitis and preparation method thereof

Examples

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preparation example Construction

[0049] The present invention also provides a preparation method of the described nasal drops for the treatment of rhinitis, comprising the following steps:

[0050] (1) Dissolve chloramphenicol, dexamethasone sodium phosphate, chlorpheniramine maleate, ribavirin, metronidazole, lidocaine hydrochloride and polyethylene glycol in a solvent of 30-50 vol%, Then pass in CO 2 to saturation, and then heated at 50 to 75 ° C for 15 to 30 min under sealing conditions to obtain medicinal solution A;

[0051] (2) Adjust the pH value of liquid A to 6.3-6.8, then add borneol, neomycin sulfate, medicinal charcoal, preservatives, stabilizers, osmotic pressure regulators and the remaining 50-70 vol% solvent, and then carry out The medicinal charcoal is removed by filtration to obtain medicinal solution B;

[0052] (3) The medicinal solution B is filtered twice with a 0.2-0.4 μm microporous membrane, and the obtained filtrate is encapsulated to obtain a nasal drop for treating rhinitis.

[0...

Embodiment 1

[0058] A kind of nasal drop for the treatment of rhinitis, its raw material composition is as shown in table 1, and preparation step is as follows:

[0059] (1) Mix 30g of chloramphenicol, 0.24g of dexamethasone sodium phosphate, 2.4g of chlorpheniramine maleate, 12g of ribavirin, 0.45g of metronidazole, 0.24g of lidocaine hydrochloride and 90g of polyethylene glycol The alcohol was dissolved in 45 vol% solvent, then passed through CO 2 to saturation, and then heated at 60°C for 25min under sealed conditions to obtain medicinal solution A;

[0060] (2) Adjust the pH value of liquid A to 6.3-6.8, then add 6g of borneol, 0.18g of neomycin sulfate, 1g of medicinal charcoal, 0.15g of ethyl paraben, 0.04g of stabilizer, 9g of sodium chloride and the rest 45vol% of solvent, then carry out circulating filtration, remove medicinal charcoal, obtain medicinal liquid B;

[0061] (3) The medicinal solution B was filtered twice with a 0.22 μm microporous membrane, and the obtained filtra...

Embodiment 2

[0064] A kind of nasal drop for the treatment of rhinitis, its raw material composition is as shown in Table 1, the preparation method of described nasal drop is the same as Example 1, and the nasal drop A2 for the treatment of rhinitis is obtained.

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Abstract

The invention relates to the technical field of medicine preparation and in particular relates to nasal drops for treating rhinitis and a preparation method thereof. The nasal drops for treating the rhinitis are prepared from active components, auxiliary materials and a solvent, wherein the active components comprise chloramphenicol, dexamethasone sodium phosphate, chlorpheniramine maleate, ribavirin, metronidazole, lidocaine hydrochloride, borneol and neomycin sulfate; the auxiliary materials comprise a preservative, polyethylene glycol, a stabilizer and an osmotic pressure regulator. According to the nasal drops, the chloramphenicol, the dexamethasone sodium phosphate, the chlorpheniramine maleate, the ribavirin, the metronidazole, the lidocaine hydrochloride, the borneol and the neomycin sulfate are used as the active components, so that the nasal drops have the effects of freeing orifices and smoothening breath, relieving swelling and pain and repairing lesion tissues of nasal mucosa and have a good medicinal effect and people do not have dependence after the nasal drops are used for a long period of time.

Description

technical field [0001] The invention relates to the technical field of drug preparation, in particular to a nasal drop for treating rhinitis and a preparation method thereof. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity, which is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors and some systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis. Rhinitis is a common and frequently-occurring disease in clinical practice, which can induce a variety of upper respiratory tract diseases. In recent years, air pollution has become more and more serious, and the inhalation of harmful substances and allergic substances through the nose has increased, so that the incidence of rhinitis and sinusitis is obviously on the rise. Children and adolescents with underdeveloped nasal mucosal barrier, low antibacterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K9/08A61K47/10A61P11/02A61K31/045A61K31/165A61K31/167A61K31/4164A61K31/4402A61K31/573A61K31/7036
CPCA61K9/0043A61K9/08A61K31/045A61K31/165A61K31/167A61K31/4164A61K31/4402A61K31/573A61K31/7036A61K31/7056A61K47/10A61P11/02A61K2300/00
Inventor 眭荣春邹明明曾文辉谭淑兰
Owner 江西润泽药业有限公司
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