Biological anti-adhesion repairing auxiliary material and preparation method thereof
An anti-adhesion and biological technology, applied in medical science, surgery, etc., can solve the problems of ineffective prevention of intrauterine adhesion wound repair, inability to inhibit inflammation, fibrosis, etc., to overcome tissue adhesion, good fibrosis, and prevent postoperative Adhesion effect
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Embodiment 1
[0041] This embodiment provides a biological anti-adhesion repair auxiliary material, which uses polylactic acid film as the middle anti-adhesion layer, and small intestinal submucosa matrix material film as the upper and lower surface layers, and the surface layers cover the middle anti-adhesion layer to form a sandwich structure.
[0042] Wherein, the thickness of the middle anti-adhesion layer is 3cm; the thickness of the upper surface layer is 0.03mm, and the thickness of the lower surface layer is 0.03mm.
Embodiment 2
[0044] This embodiment provides the preparation method of the biological anti-adhesion repair auxiliary material described in embodiment 1, specifically:
[0045] 1) Add 6g of polylactic acid into 60ml of chloroform solvent, stir it magnetically at room temperature to dissolve it completely, and obtain a uniform and transparent solution; pour the solution into a glass container, dry it in a fume hood for 12 hours, and then put it in a vacuum drying oven Dry in medium for 10h to obtain polylactic acid film;
[0046] 2) Use the small intestinal submucosa matrix material film as the surface layer, add polylactic acid film between the upper and lower surface layers, and act for 1 hour under the condition of vacuum pressure of -760mmHg;
[0047] Cut the formed product into 2cm*0.5cm size, put it in the package, and sterilize it by irradiation.
Embodiment 3
[0049] This embodiment provides a preparation method of biological anti-adhesion repair auxiliary materials, specifically:
[0050] 1) Add 50g of polylactic acid into the injection molding machine, and directly perform injection molding to obtain a polylactic acid film; wherein, the injection molding temperature is controlled at 160°C, and the mold temperature is controlled at 80°C;
[0051] 2) The small intestine submucosa matrix material film is used as the surface layer, polylactic acid film is added between the upper and lower surface layers, and medical chitosan adhesive is used to bond as a whole;
[0052] Cut the formed product into a size of 7cm*10cm, put it in the package, and sterilize it by irradiation.
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