Biological anti-adhesion repairing auxiliary material and preparation method thereof

An anti-adhesion and biological technology, applied in medical science, surgery, etc., can solve the problems of ineffective prevention of intrauterine adhesion wound repair, inability to inhibit inflammation, fibrosis, etc., to overcome tissue adhesion, good fibrosis, and prevent postoperative Adhesion effect

Inactive Publication Date: 2019-04-16
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material is only for unilateral repair, and cannot effectively prevent intrauterine adhesions and wound repair after adhesion separation
[0005] The current materials have the following defects: 1) A single anti-adhesion product can only provide a physical barrier, but cannot inhibit inflammation, fibrosis, and promote the effect of uterine regeneration and repair
2) The measures to promote the regeneration and repair of endometrium can only promote the repair of endometrium, and have no effect on preventing uterine cavity re-adhesion

Method used

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  • Biological anti-adhesion repairing auxiliary material and preparation method thereof
  • Biological anti-adhesion repairing auxiliary material and preparation method thereof
  • Biological anti-adhesion repairing auxiliary material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This embodiment provides a biological anti-adhesion repair auxiliary material, which uses polylactic acid film as the middle anti-adhesion layer, and small intestinal submucosa matrix material film as the upper and lower surface layers, and the surface layers cover the middle anti-adhesion layer to form a sandwich structure.

[0042] Wherein, the thickness of the middle anti-adhesion layer is 3cm; the thickness of the upper surface layer is 0.03mm, and the thickness of the lower surface layer is 0.03mm.

Embodiment 2

[0044] This embodiment provides the preparation method of the biological anti-adhesion repair auxiliary material described in embodiment 1, specifically:

[0045] 1) Add 6g of polylactic acid into 60ml of chloroform solvent, stir it magnetically at room temperature to dissolve it completely, and obtain a uniform and transparent solution; pour the solution into a glass container, dry it in a fume hood for 12 hours, and then put it in a vacuum drying oven Dry in medium for 10h to obtain polylactic acid film;

[0046] 2) Use the small intestinal submucosa matrix material film as the surface layer, add polylactic acid film between the upper and lower surface layers, and act for 1 hour under the condition of vacuum pressure of -760mmHg;

[0047] Cut the formed product into 2cm*0.5cm size, put it in the package, and sterilize it by irradiation.

Embodiment 3

[0049] This embodiment provides a preparation method of biological anti-adhesion repair auxiliary materials, specifically:

[0050] 1) Add 50g of polylactic acid into the injection molding machine, and directly perform injection molding to obtain a polylactic acid film; wherein, the injection molding temperature is controlled at 160°C, and the mold temperature is controlled at 80°C;

[0051] 2) The small intestine submucosa matrix material film is used as the surface layer, polylactic acid film is added between the upper and lower surface layers, and medical chitosan adhesive is used to bond as a whole;

[0052] Cut the formed product into a size of 7cm*10cm, put it in the package, and sterilize it by irradiation.

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Abstract

The invention relates to a biological anti-adhesion repairing auxiliary material and a preparation method thereof. A synthetic material or a cross-linked materialis used as an intermediate anti-adhesion layer of the biological anti-adhesion repairing auxiliary material, natural extracellular matrix is upper and lower surface layers, and the surface layers cover the intermediate anti-adhesion layerto form a sandwich structure. The biological anti-adhesion repairing auxiliary material can releasemany growth factors during degradation, provide a good physiological environment for inhibiting fibrosis, inhibiting inflammation and reducing bleeding for damaged tissue regeneration, thereby promoting healing, can be used as a good tissue substitute before a damaged part is regenerated, and can effectively prevent the occurrence of adhesion.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a biological anti-adhesion repair auxiliary material and a preparation method thereof. Background technique [0002] Postoperative adhesion is an abnormal structure in which the fibrous band of connective tissue combines with adjacent tissues or organs after surgery. It is generally caused by trauma, infection, bleeding, local ischemia, dehydration, and foreign bodies caused by surgery. It affects the effect of surgery or even It is one of the key issues in the success or failure of the operation. Postoperative adhesions can be divided into two types: primary and secondary. They usually appear within a short period of time after surgery, and the degree of adhesion is unpredictable. The occurrence rate of postoperative adhesion is extremely high, and it is almost an inevitable pathophysiological process in the postoperative healing process. Adhesions generally lead to serious complication...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/00A61L31/14
CPCA61L31/005A61L31/06A61L31/14A61L31/148C08L67/04
Inventor 兴丽娟牛睿张玉兰代金明李次会
Owner BEIJING DATSING BIO TECH
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