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Application of betulinic acid to excretion of lead from organism and preparation of lead excretion food, health care product and medicament

A technology of betulinic acid and health products, which is applied in health products and medicines. Betulinic acid can solve the problems of unsuitable long-term continuous use, short lead removal cycle, liver and kidney toxicity, etc. problems, achieve preventive protective effect, therapeutic effect, reduce tissue damage, and expand the effect of application range

Active Publication Date: 2019-04-26
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main methods of domestic and international lead discharge that have been reported at present have: 1) Chelating agent, as drug treatment such as disodium calcium edetate and dimercaptosuccinic acid, the lead-dispelling period of this class drug is short, and treatment is quick, but this class drug often Discharge of the body's indispensable calcium, iron and zinc, etc., causing element balance imbalance, and also has liver and kidney toxicity, so it should not be taken continuously for a long time; 2) Vitamins, such as vitamin C, vitamin E and vitamin D
Supplementing vitamin C slows down the symptoms of lead poisoning, supplementing vitamin E can resist the peroxidation caused by lead; supplementing vitamin D can affect the absorption and deposition of lead by regulating calcium and phosphorus, but vitamin drugs cannot promote the excretion of lead
3) Nutrients such as zinc and selenium have an antagonistic effect on zinc, selenium and lead, thereby preventing the body from absorbing lead, but this antagonistic efficiency is limited and cannot reduce the residual amount of lead in the tissue

Method used

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  • Application of betulinic acid to excretion of lead from organism and preparation of lead excretion food, health care product and medicament
  • Application of betulinic acid to excretion of lead from organism and preparation of lead excretion food, health care product and medicament
  • Application of betulinic acid to excretion of lead from organism and preparation of lead excretion food, health care product and medicament

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Protective effect of betulinic acid pretreatment on high lead mice

[0024] 1. Experimental animals and experimental design

[0025] 60 healthy male KM mice, 4-5w, SPF grade, body weight (20±2) g, license number: (Xiang) 2009-0004, the feed was M02 mouse common breeding feed, mice and feed were purchased from Hunan Slack Jingda Laboratory Animal Company. Place the mice in a breeding room at (22-25)°C and a relative humidity of 50% to 70%. After feeding for 1 week, they were randomly divided into 6 groups, namely, the blank control group, the lead acetate group (model control group), and the betulinic acid low , medium and high doses + lead acetate group (betulinic acid was given at 0.5, 2 and 8 mg / kg bw respectively), edetate disodium calcium group (positive control group). The administration methods of each group were as follows: the blank control group used free drinking water and basic feed, and the remaining 5 groups drank 0.1% lead acetate solution every day to p...

Embodiment 2

[0047] Therapeutic effect of betulinic acid on high lead mice

[0048] 1. Experimental animals and experimental design

[0049] 40 healthy male KM mice, 4-5w, SPF grade, body weight (20±2) g, license number: (Xiang) 2009-0004, the feed is M02 mouse common breeding feed, mice and feed were purchased from Hunan Slack Jingda Laboratory Animal Company. The mice were placed in a breeding room at (22-25)°C and the relative humidity was 50%-70%, and after feeding for 1 week, they were randomly divided into 4 groups, with 10 mice in each group. Namely blank control group, lead acetate group (model control group), betulinic acid group (administrated at 8 mg / kgbw), edetate disodium calcium group (positive control group). All animals had free access to water and food every day, and were given standard feed and deionized water. The blank control group was intraperitoneally injected with 0.9% sodium chloride (equivalent to the amount of lead acetate injection) every day, and the other g...

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Abstract

The invention provides application of betulinic acid to excretion of lead from organism and preparation of a lead excretion food, health care product and medicament, and belongs to the technical fieldof application of the betulinic acid. The betulinic acid can reduce the residual amount of blood lead, brain lead, liver lead, kidney lead and bone lead, facilitate excretion of urine lead and excrement lead and achieve a very good lead eliminating effect, thereby reducing tissue damage caused by lead. The betulinic acid is safe and effective, and a new thought is provided for the development ofmore natural medicinal active components for treating lead poisoning; meanwhile, the application range of the betulinic acid is widened; the betulinic acid has important scientific value and medical significance.

Description

technical field [0001] The invention belongs to the application technical field of betulinic acid, and in particular relates to the application of betulinic acid in lead-expelling body and preparation of lead-expelling food, health products and medicines. Background technique [0002] Lead is a widespread industrial pollutant. With the continuous development of modern industrialization, people have more and more opportunities to be exposed to lead. Lead is also a common heavy metal element with multi-system and multi-organ toxicity in the environment. Lead enters the body through the digestive tract, respiratory tract and skin, and combines with functional groups in some proteins, enzymes and amino acids in the body. Due to its high accumulation and low excretion rate, lead has serious toxicity to the body. The lead that enters the body will cause damage to important tissues and organs such as bone tissue, liver and kidney. Studies have found that 70% to 90% of the lead th...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P39/02A61P15/08A61P1/00A23L33/10
CPCA23L33/10A23V2002/00A61K31/56A61P1/00A61P15/08A61P39/02A23V2200/30A23V2250/21
Inventor 易金娥邬静袁志航
Owner HUNAN AGRICULTURAL UNIV
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