Degradable tissue regeneration barrier membrane and preparing method thereof

Abstract

The invention belongs to the field of biological materials and particularly relates to a degradable tissue regeneration barrier membrane and a preparing method thereof. The barrier membrane is prepared from, by mass, 35-55% of a calcium alginate solution, 30-40% of a chitosan solution and 5-35% of a platelet-rich fibrin solution. The barrier membrane has good mechanical performance and can effectively diminish inflammation. In addition, compared with a single-component chitosan solution, the barrier membrane has greatly reduced degradation time and meets a requirement that mechanical performance, sterilization and inflammation diminishing performance and degradation performance are integrated.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a degradable tissue regeneration barrier film and a preparation method thereof. Background technique [0002] Periodontitis occurs in the periodontal tissue and is characterized by irreversible loss of connective tissue attachment and alveolar bone supporting tissue. In recent decades, periodontologists have become interested in regenerating the tissue damaged by periodontitis, by using the graft material used in barrier technology as a scaffold to prevent the disintegration of the barrier to provide a space for just The formed blood clot stabilizes the affected area, guiding it to create conditions for periodontal tissue regeneration. [0003] According to clinical needs, an effective barrier membrane should have appropriate mechanical strength to keep fast-growing repair tissues (epithelium and gingival connective tissue) away from the root surface, maintaining ...

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Problems solved by technology

[0006] Chinese patent application CN108379656A discloses a biodegradable composite guide bone regeneration barrier film. The barrier film is made of biomedical magnesium strips and polylactic acid films pressed on the top and bottom of the magnesium strips. The invention has good biophase Capacitance, certain mechanical strength, degradability, can selectively guide tissue regeneration, however, because the degradation products of polylactic acid will cause a drop in local pH value, it is easy to cause aseptic inflammatory reactions in patients

Chinese patent application CN101927036A discloses a temperature-sensitive gel-guided tissue regeneration barrier membrane, which is composed of chitosan solution and sodium β-glycerophosphate, and has good biocompatibility, but the barrier membrane degrades for a long time. And the mechanical strength is poor, which limits its application in periodontal tissue regeneration

[0007] To sum up, currently used biodegradable tissue regeneration barrier membrane materials have the problems of mechanical properties, easy to cause inflammation, and biodegradable properties that cannot be achieved at the same time.

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