New application of neoagarool igosaccharode and combination containing neoagarool igosaccharode

A new technology of agar oligosaccharides and compositions, which is applied in new fields of application in preventing hair loss and promoting hair growth, can solve problems that have not been reported yet, and achieve significant efficacy, hair loss prevention, and good safety effects

Active Publication Date: 2019-05-10
AQUABRAIN BIOTECH XIAMEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it is a new agar oligosaccharide with a single component or a mixed component, or oligosaccharides from other seaweeds, its functions for protecting hair and preventing hair loss have not been reported yet.

Method used

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  • New application of neoagarool igosaccharode and combination containing neoagarool igosaccharode
  • New application of neoagarool igosaccharode and combination containing neoagarool igosaccharode
  • New application of neoagarool igosaccharode and combination containing neoagarool igosaccharode

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The effect of embodiment 1 new agar oligosaccharides on androgenetic alopecia cell model in vitro

[0055] Taking dermal papilla cells as the test object, a certain concentration of dihydrotestosterone (DHT) was used to stimulate the in vitro cell model of androgenetic alopecia, and then the in vitro model of androgenetic alopecia was treated with new agar oligosaccharides, and minoxidil was used as a positive control. Evaluated by detecting the changes of vascular endothelial growth factor (VEGF), DKK-1, transforming growth factor (TGF-β2), β-catenin (β-catenin) and androgen receptor (AR) secreted by dermal papilla cells Efficacy of new agar oligosaccharides in promoting hair regeneration.

[0056] The new agarose oligosaccharide used in this embodiment has the following three kinds: (1) new agarose (DP2); (2) new agarotetraose and new agarosexose (DP4-6), wherein the new agarose The proportion is 55%, and the proportion of new agarose is 45%; (3) new agarose, new aga...

Embodiment 2

[0083] Embodiment 2 percutaneous penetration test

[0084] The transdermal penetration test aims to investigate the permeability of new agarose on the skin. Due to the barrier effect of cells, a high concentration of new agarose is used to increase the content of new agarose in the sample after penetration and ensure the accuracy of the test. sex. At the same time, it is designed to add glycerin and nonionic surfactants (such as polyethylene glycol) to the new agarose to enhance its percutaneous absorption performance. The selection and concentration design of the penetration enhancer are shown in Table 3.

[0085] Table 3 Selection and concentration design of penetration enhancer

[0086] combination 1

1% neoagarose

combination 2

1% new agarobiose + 1% glycerin

combination 3

1% new agarobiose + 2% glycerin

combination 4

1% new agarobiose + 1% PEG400

combination 5

1% new agarobiose + 2% PEG400

combination 6

1...

Embodiment 3

[0089] Embodiment 3 mouse hair growth test

[0090] Get 18 guinea pigs, be divided into 3 groups at random (blank group, test 1 group, test 2 groups), 6 in every group, wherein blank group is normal saline group, test 1 group new agarose group (containing 5000ppm new agarose two sugar), and the test group 2 was the composition group (5000ppm neoagarose + 2% glycerol + 1% PEG400). Inject an appropriate amount of anesthesia into the guinea pigs, and after they are anesthetized, place a 3×3cm 2 Remove the body hair, be careful not to damage the skin, wipe it clean with physiological saline, and put the guinea pig back into the cage. After 24 hours, administer 500 μL of each guinea pig in the hair removal area, apply evenly, once a day, for 30 consecutive days, and randomly cut 10 body hairs from the guinea pig administration site after 30 days of administration, and measure their length and weight. Using the average value as an index to compare the body hair growth of guinea pi...

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Abstract

The invention relates to new application of neoagarool igosaccharode as a hair growth agent or hair care agent and a combination containing the neoagarool igosaccharode, in particular to the application of the neoagarool igosaccharode in preparing products for improving and / or promoting hair growth or eliminating and / or relieving diseases or states related to the poor hair growth state. The neoagarool igosaccharode for the application is clear in mechanism, definite in function, free of side effects, high in safety and remarkable in effect. The combination containing the neoagarool igosaccharode has the remarkable hair loss preventing and hair growth functions and is free of irritation and side effects and high in safety.

Description

technical field [0001] The present invention relates to the new application of the new agar oligosaccharide, especially the effect of the new agar oligosaccharide as an active ingredient for improving hair growth, more particularly the new application for preventing hair loss and promoting hair growth. Background technique [0002] Hair loss and the baldness it causes is a common phenomenon, and the mental stress it causes brings many troubles and obstacles to interpersonal relationships and social life. With the acceleration of the pace of life, the increase of life pressure and environmental pressure, the people suffering from hair loss are getting younger and younger, and not only men, but also women's hair loss is gradually increasing, so there are many therapeutic drugs for preventing hair loss , hair care external products, hair growth external products. [0003] The causes of hair loss are complex and are the combined effects of various factors. The most common type...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K31/715A61P17/14A61K8/73A61K8/60A61Q7/00A61Q5/12
Inventor 张春毅曾润颖侯艳平王斐曾翰庭
Owner AQUABRAIN BIOTECH XIAMEN CO LTD
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