A thermosensitive polymer and its synthesis method and thermosensitive injectable hydrogel

Abstract

Provided are a temperature-sensitive polymer, a synthesis method thereof, and a temperature-sensitive injectable hydrogel. When preparing the temperature-sensitive polymer, first synthesising GelMA and UPyMA; dispersing the three monomers UPyMA, GelMA, and MEOnMA in an alkaline aqueous solution with a pH of 8-11, and removing the oxygen; at room temperature, adding a redox initiator or a water-soluble initiator to make a polymerisation reaction, and continuing until fully reacted; and purifying the product and removing the solvent to obtain a temperature-sensitive polymer. The present temperature-sensitive polymer can formulate an injectable aqueous phase temperature-sensitive polymer sol in a constant pressure environment no higher than a corresponding low critical phase transition temperature and no lower than a water solidification temperature, and the sol can form a gel immediately above the corresponding low critical phase transition temperature. The temperature-sensitive injectable hydrogel has dynamic mechanical properties and good biocompatibility, and can be used in biomedical fields such as tissue engineering, controlled drug release, and three-dimensional cell culture.

Description

technical field [0001] The invention belongs to the technical fields of polymer physics, polymer chemistry, biomedical materials and tissue engineering, and specifically relates to the synthesis of a temperature-sensitive polymer with good biocompatibility and the preparation and preparation of a corresponding temperature-sensitive injectable hydrogel. application method. Background technique [0002] Hydrogel is a gel in which the aqueous phase system is used as the dispersion medium. The molecular composition and structure in the gel network are complex and changeable, and have good designability; the aqueous phase dispersion system can endow the gel with good biocompatibility. Due to the above characteristics, hydrogel can provide cells with an environment for retention or proliferation, and can also contain drugs or proteins for controlled release. After the task is completed, it can be biodegraded and excreted as metabolic waste. It has great potential in biomedicine. ...

AI Technical Summary

Problems solved by technology

Similar to the existing thermosensitive hydrogels based on the low critical phase transition temperature, mainly rely on the hydrophobic aggregation of polymers above the low critical phase transition temperature to form a cross-linked structure, and the strength of the cross-linking points formed by this hydrophobic aggregation is low, resulting in unstable The mechanical properties of the gel and the cross-linked structure that is not resistant to swelling greatly limit its application range

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