Acicular hydroxyapatite micro-nanostructure coating on magnesium alloy surface and preparation method thereof

A hydroxyapatite, micro-nano structure technology, applied in coating, medical science, prosthesis and other directions, can solve the problems of complex equipment and formula, not uniform and dense, high preparation temperature, and improve the implantation success rate and technology. Simple, easy-to-recipe effects

Active Publication Date: 2019-05-17
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantages of high preparation temperature, many coating defects, insufficient uniformity and compactness, complex equipment and formula in the prior art, and provide a method for preparing fine needle-shaped hydroxyapatite micro-nano structure coating on the surface of medical magnesium alloy. The preparation method of the layer does not need to use additives and pulse currents, and is synthesized in the next step under milder conditions, and the prepared hydroxyapatite coating is uniform and dense, has a fine needle-like micro-nano structure, and has good corrosion resistance

Method used

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  • Acicular hydroxyapatite micro-nanostructure coating on magnesium alloy surface and preparation method thereof
  • Acicular hydroxyapatite micro-nanostructure coating on magnesium alloy surface and preparation method thereof
  • Acicular hydroxyapatite micro-nanostructure coating on magnesium alloy surface and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] (1) Pretreatment of the magnesium alloy substrate: the AZ31B magnesium alloy substrate is polished with 400#, 600#, 800#, and 1200# sandpaper in sequence; the polished magnesium alloy substrate is sequentially washed in absolute ethanol, acetone, and deionized water Ultrasonic cleaning with an ultrasonic cleaner for 10 minutes and drying;

[0033] (2) Preparation of electrolyte solution for electrochemical deposition: weigh Ca(NO 3 ) 2 4H 2 O and NH 4 h 2 PO 4 , were dissolved in deionized water, so that Ca(NO 3 ) 2 4H 2 The concentration of O is 0.01mol / L, NH 4 h 2 PO 4The concentration of the solution is 0.006mol / L; the above two solutions are uniformly mixed in a ratio of calcium to phosphorus molar ratio of 1.67:1 to obtain an electrolyte for electrochemical deposition;

[0034] (3) Electrochemical deposition: use a platinum electrode as the cathode and a magnesium alloy as the anode, immerse in the electrolyte solution, place the cathode and the anode in...

Embodiment 2

[0038] (1) Pretreatment of the magnesium alloy matrix: grind the medical magnesium alloy samples with 400#, 600#, 800#, 1200# sandpaper in sequence; use the polished magnesium alloy in absolute ethanol, acetone, and deionized water in sequence Ultrasonic cleaner ultrasonic cleaning 15min, drying.

[0039] (2) Preparation of electrolyte solution for electrochemical deposition: weigh CaCl 2 and KH 2 PO 4 , were dissolved in deionized water so that CaCl 2 The concentration is 0.05mol / L, KH 2 PO 4 The concentration of the above two solutions is 0.03mol / L; the above two solutions are uniformly mixed according to the ratio of the molar ratio of calcium to phosphorus of 1.67:1, and the electrolyte for electrochemical deposition is obtained.

[0040] (3) Electrochemical deposition: use a platinum electrode as the cathode and a magnesium alloy as the anode, immerse in the electrolyte solution, place the cathode and the anode in parallel, keep a distance of 2cm, turn on the DC stab...

Embodiment 3

[0044] (1) Pretreatment of the magnesium alloy matrix: grind the medical magnesium alloy samples with 400#, 600#, 800#, 1200# sandpaper in sequence; use the polished magnesium alloy in absolute ethanol, acetone, and deionized water in sequence Ultrasonic cleaner ultrasonic cleaning 10min, drying;

[0045] (2) Preparation of electrolyte solution for electrochemical deposition: weigh Ca(NO 3 ) 2 4H 2 O and NH 4 h 2 PO 4 , were dissolved in deionized water, so that Ca(NO 3 ) 2 4H 2 The concentration of O is 0.0417mol / L, NH 4 h 2 PO 4 The concentration of the solution is 0.025mol / L; the above two solutions are uniformly mixed in a ratio of calcium to phosphorus molar ratio of 1.67:1 to obtain an electrolyte for electrochemical deposition;

[0046] (3) Electrochemical deposition: use a platinum electrode as the cathode and a magnesium alloy as the anode, immerse in the electrolyte solution, place the cathode and the anode in parallel, keep a distance of 4cm, turn on the ...

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Abstract

The invention belongs to the technical field of surface modification of degradable magnesium alloy implants, and particularly relates to an acicular hydroxyapatite micro-nanostructure coating on the magnesium alloy surface and a preparation method thereof. The preparation method comprises the following steps of immersing a pretreated magnesium alloy substrate in an electrolyte solution for electrochemical deposition, using a platinum electrode as a cathode and magnesium alloy as an anode, turning on a DC stabilized power supply, performing electrochemical deposition and then performing alkaliheat treatment to obtain the hydroxyapatite coating on the magnesium alloy surface. The electrolyte solution for the electrochemical deposition has simple formula, has no accelerator or oxidant, and does not need to adjust the pH value. The electrochemical deposition method with low temperature and low current density is easy to control and low in cost. The prepared hydroxyapatite coating is uniform and dense, has high purity and good corrosion resistance and has the acicular micro-nano structure, which is beneficial to adhesion and growth of the cells on the surface of the coating. The implantation success rate of the magnesium alloy implants can be improved.

Description

technical field [0001] The invention belongs to the technical field of surface modification of degradable magnesium alloy implants, and in particular relates to a fine needle-shaped hydroxyapatite micro-nano structure coating on the surface of magnesium alloy and a preparation method thereof. Background technique [0002] As a biomedical implant material, magnesium alloy has good biocompatibility, bioactivity and excellent biodegradability. Compared with metal materials such as cobalt-based alloys, stainless steel, and titanium alloys commonly used in clinical medicine, the elastic modulus and density of magnesium alloys are the closest to those of human bone, making it an ideal bone repair material. However, due to the poor corrosion resistance of magnesium alloys in the physiological environment, the degradation rate is too fast, which often causes the pH value of the local environment at the implant site to be too high and a large amount of hydrogen to be released in a sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/32A61L27/50
Inventor 孙瑞雪于文韬陈克正
Owner QINGDAO UNIV OF SCI & TECH
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