A kind of preparation method and application of total flavonoids of dragon's blood

A technology of total flavonoids of dragon's blood and dragon's blood, which is applied in the field of medicine, can solve problems such as easy elution, toxic and side effects, and complex components, and achieve the effects of lower extraction temperature, long-lasting drug effect, and difficult elution
CN109771544BActive Publication Date: 2021-11-30SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Publication Date
2021-11-30

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Abstract

The invention provides a preparation method of total flavonoids of dragon's blood. The medicinal material of dragon's blood is crushed into a coarse powder, and a mixed solvent of ethanol and ethyl acetate is added, and the reflux extraction is carried out at 50-69°C for 2 times, each time for 15-60°C. 29 minutes will do. In addition, the present invention also provides the application of the total flavonoids of dragon's blood in the preparation of medicines for preventing and treating autoimmune diseases, medicines for weight loss, medicines for tumor diseases, medicines for acute and chronic respiratory diseases, and medicines for cardiovascular diseases. The total flavonoids of dragon's blood extracted by the invention are less toxic to animals than dragon's blood, and the activity of total flavonoids of dragon's blood in blocking Kv1. The enrichment of components removes impurities that may cause toxic and side effects, improves safety and enhances the blocking effect on Kv1.3 potassium channels; in addition, the total flavonoids of Dracaena japonicus have a higher affinity to Kv1.3 potassium channels Based on dragon's blood B, the synergistic effect of various active ingredients in blocking Kv1.3 potassium channel in the total flavonoids of dragon's blood was realized.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of total flavonoids of dragon's blood. Background technique

[0002] The normal immune response of the body can effectively resist the intrusion of external pathogenic microorganisms. When the body's immune function is disordered and autoimmune antigens appear, the body's immune system will produce autoantibodies, which can cause a variety of autoimmune diseases by destroying its own organs and tissues. Since the exact pathogenesis of autoimmune diseases has not yet been clarified, there is currently no complete cure in clinical practice. Steroid traditional immunosuppressants are often used, such as cyclophosphamide, dexamethasone, etc. These hormone drugs have significant anti-inflammatory effects and can quickly improve the clinical symptoms of patients with autoimmune diseases, but these drugs cannot eliminate the cause, and t...

Claims

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