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Anhydrous matrix for oral products and application of matrix

An oral product and matrix technology, applied in oral care, inorganic active ingredients, cosmetic preparations, etc., can solve problems such as loose teeth, alveolar bone destruction, and loss

Active Publication Date: 2019-05-31
KUNMING LANCHIE DENTAL HOSPITAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If left unchecked, gingivitis may develop into periodontitis, causing alveolar bone destruction, eventually leading to loosening and loss of teeth

Method used

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  • Anhydrous matrix for oral products and application of matrix
  • Anhydrous matrix for oral products and application of matrix
  • Anhydrous matrix for oral products and application of matrix

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Embodiment 1: The product is a paste, prepared with the following raw materials: didecyldimethyloxyproline ammonium, propylene glycol, polyvinylpyrrolidone, carbamide peroxide, fumed silica, menthol, water-soluble pigment, water-soluble Peppermint Flavor Powder (Firmenich, APL0504), Sucralose, Sodium Saccharin, Disodium EDTA, Poloxamer.

[0119] The preparation method is as follows:

[0120] A. Uniformly disperse polyvinylpyrrolidone in propylene glycol, and then stand to swell fully to obtain colloid A;

[0121] B. Heating the propylene glycol, and fully dissolving the poloxamer in the propylene glycol to obtain solution B;

[0122] C. Add cationic antibacterial agent, sweetener, water-soluble pigment, antioxidant, chelating agent, water-soluble essence and other components into solution B respectively, and fully stir to obtain solution C;

[0123] D. Divide the required fumed silica into three parts, two of which are added to solution C in two times, and after fully...

Embodiment 2

[0127] Embodiment 2: the mass ratio of raw materials of 9 formulas is listed in the table below. For each formula, the raw materials were obtained according to the mass ratio, and the homogeneous paste was obtained according to the preparation method of Example 1.

[0128] The raw material mass ratio (W / W) of table 9 formula

[0129]

[0130] *3.52 parts of carbamide peroxide in recipe 1 and recipe 2 is about 2.86g of carbamide peroxide, which is about 1g of hydrogen peroxide; 7.23 parts of carbamide peroxide in recipe 3 and recipe 4 is about 5.72g of carbamide peroxide, which is about 2 g hydrogen peroxide; 0.33 parts of carbamide peroxide in formula 5 and formula 8 is about 0.29 g carbamide peroxide, about 0.1 g hydrogen peroxide.

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Abstract

The invention discloses an anhydrous matrix for oral products and application of the matrix, and belongs to the technical field of the oral products. The anhydrous matrix is characterized in that theoral products can stably exist when one of or both of a peroxide source and a cationic antibacterial agent are added into the matrix; the matrix is composed of propylene glycol, fumed silica and polyvinylpyrrolidone, and the weight ratio of the three components is 1:(0.03-015):(0.01-0.08). The cationic antibacterial agent can be a quaternary ammonium salt or a guanidine antibacterial agent, and can be didecyl dimethyl ammonium praline sodium (PODA) or cetylpyridinium chloride. The peroxide source can be a complex of urea peroxide or calcium peroxide, or percarbonate or perborate, or hydrogen peroxide, or polyvinylpyrrolidone hydrogen peroxide. The anhydrous matrix is used for preparing products for removing oral biofilm. The matrix achieves the effect that in the same system, the peroxidesource and the cationic antibacterial agent can stably coexist and synergistically inhibit and damage the biofilm.

Description

technical field [0001] The invention belongs to the technical field of oral products, and in particular relates to a water-free matrix which can stabilize one or both of a peroxide source and a cationic antibacterial agent, and an oral product made on the basis of it is effective in removing oral organisms. applications in the membrane field. Background technique [0002] The peroxide source refers to the compound containing peroxy group -O-O-, which is characterized by the presence of peroxide ion in the molecule. After the peroxide is dissolved in water, the oxygen element of the peroxy group -O-O- is in a high-valent state, and it can undergo redox by itself, one oxygen becomes -2 valence, and one oxygen becomes 0 valence, which is the oxygen atom, also known as new Ecological oxygen, the oxygen atom is unstable, can take away the electrons of the bacteria and become a stable -2-valent oxygen ion to achieve the effect of sterilization. Peroxides are widely used in the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/81A61K8/25A61K8/34A61K8/38A61P1/02A61P31/02A61P31/04A61Q11/00
CPCA61K33/40A61K9/0063A61K47/10A61K47/32A61K47/02A61K47/186A61K47/08A61Q11/00A61K2800/31A61K8/25A61K8/345A61K8/8176A61K8/86A61K8/22A61P31/02A61P1/02A61K33/00A61K31/79A61K2300/00A61K38/1729
Inventor 徐芸张磊陆可望
Owner KUNMING LANCHIE DENTAL HOSPITAL CO LTD
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