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Synthesis method of medium-chain triglyceride

A technology of triglyceride and synthesis method, applied in the field of medicine, can solve the problems of only reaching about 85%, low oil content, high cost, etc., and achieve the effects of improving yield, improving conversion rate and improving purity

Inactive Publication Date: 2019-06-04
广州隽沐生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the preparation method of separation and purification in natural coconut oil or palm oil is expensive, and the yield is extremely low, and the oil content is also low, so esterification is generally used to prepare
However, the yield of the existing esterification reaction is generally low, about 85%, and it is difficult to further increase the yield.
For example, the Chinese patent application document with the publication number CN107129430A discloses a method for synthesizing medium-chain triglycerides of raw materials, by mixing glycerol and fatty acids at a ratio of 1:5-7 in parts by mass at a vacuum room temperature of -0.09MPa , and take 50-270 minutes to slowly raise the temperature to 150°C-245°C, and gradually adjust the pressure to not higher than -0.02MPa as the temperature rises, and keep it warm at the esterification temperature of 150°C-245°C for 120-420 minutes. After the chemical reaction is finished, the residual fatty acid is removed by a vacuum not greater than -0.09MPa to obtain medium-chain triglycerides. However, the maximum yield of this synthesis method can only reach about 85%, and there is still room for improvement.

Method used

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  • Synthesis method of medium-chain triglyceride
  • Synthesis method of medium-chain triglyceride

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A synthetic method for medium-chain triglycerides, comprising the following steps:

[0036] S1. Take 100g of caprylic acid, 50g of capric acid and 150g of glycerin and mix them uniformly at a temperature of 150°C and a pressure of -0.1MPa to form a mixture;

[0037] S2. Add 1.5 g of catalyst methyl sulfonate to the mixture formed by mixing S1, control the reaction temperature to 160°C, and control the reaction time to 11 hours. After the reaction, the product is distilled out by distillation to obtain the product medium-chain triglyceride ester. The reaction yield was 90%, and the product purity was 96.0%.

Embodiment 2

[0039] A synthetic method for medium-chain triglycerides, comprising the following steps:

[0040] S1. Take 100g of caprylic acid, 200g of capric acid and 450g of glycerin and mix them uniformly at a temperature of 280°C and a pressure of 0.05MPa to form a mixture;

[0041] S2. Add 7.5g of catalyst methyl sulfonate to the mixture formed by mixing S1, control the reaction temperature to 180°C, and control the reaction time to 7 hours. After the reaction, the product is distilled out to obtain the product medium-chain triglyceride ester. The reaction yield was 92%, and the product purity was 95.5%.

Embodiment 3

[0043] A synthetic method for medium-chain triglycerides, comprising the following steps:

[0044] S1. Take 100g of caprylic acid, 100g of capric acid and 200g of glycerin and mix them uniformly at a temperature of 160°C and a pressure of -0.05MPa to form a mixture;

[0045] S2. Add 8 g of catalyst methyl sulfonate to the mixture formed by mixing S1, control the reaction temperature to 160° C., and react for 10 hours. After the reaction, the product is distilled out by distillation to obtain the product medium-chain triglyceride;

[0046] S3. Take the product and add water to wash it. After standing for stratification, release the water. After repeating the above operation 5 times, take the product and dry it to obtain the final product. The reaction yield was 95%, and the product purity was 97.3%.

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Abstract

The invention relates to the technical field of medicines, aims to solve the problem of low yield of medium-chain triglyceride, and provides a synthesis method of the medium-chain triglyceride; the synthesis method comprises the following steps: S1, fatty acid and glycerol are mixed according to the mass part ratio of 1: 1-1.5; and S2, the temperature is controlled to be 160-180 DEG C, and the catalyst is added, so that the fatty acid and the glycerol are subjected to an esterification reaction. The ratio of fatty acid to glycerol is controlled to be 1: 1-1.5, and meanwhile, the temperature ofthe esterification reaction is controlled to be 160-180 DEG C, so that the esterification reaction is fully carried out, the conversion rate of the esterification reaction is improved, and the yieldis further improved.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically, it relates to a method for synthesizing medium-chain triglycerides. Background technique [0002] Medium-chain triglycerides are a product obtained by chemical methods, and are widely used in the preparation and processing of various foods. It can also be used as a clouding agent in beverages or as a lubricant and release agent for sausage pressing films. Medium chain refers to triglycerides whose fatty acid carbon chain is less than 12. [0003] Medium-chain triglycerides can also be used as raw materials for medium- and long-chain fat emulsions. Clinical application has proved that they can absorb faster and have faster curative effect than long-chain oils. They are especially used for postoperative patients, gastrointestinal diseases, infants, etc. Patients welcome. [0004] At present, the existing methods for preparing medium-chain triglycerides include two methods: on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/08C07C67/48C07C69/30
Inventor 李小蕾邹小燕周仁学蔡云峰张何明
Owner 广州隽沐生物科技股份有限公司
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