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Eye pad to improve dry eye syndrome via nano transdermal technique and preparation method thereof

A dry eye, transdermal technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of difficult to cure, low bioavailability, etc., to promote blood circulation , Improve storage stability, improve dry eye syndrome and visual fatigue

Pending Publication Date: 2019-06-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Symptoms will be relieved by treatment, but it is difficult to cure completely. The common treatment method is to use ordinary water-based eye drops to moisten and lubricate the eyeballs to relieve eye discomfort; or to use tear fluid instead of artificial tears, but they have common shortcomings Yes, the preparation has a short residence time on the ocular surface, rapid elimination, and low bioavailability

Method used

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  • Eye pad to improve dry eye syndrome via nano transdermal technique and preparation method thereof
  • Eye pad to improve dry eye syndrome via nano transdermal technique and preparation method thereof
  • Eye pad to improve dry eye syndrome via nano transdermal technique and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Dissolve 0.1g of sodium alginate and 0.01g of calcium chloride in 10ml of distilled water respectively.

[0025] (2) Dissolve 0.5ug epidermal growth factor, 1mg cyclosporine A, and 0.05mg wolfberry extract in sodium alginate stock solution, and stir for 1h.

[0026] (3) Add calcium chloride aqueous solution to the above 2 solutions within 30 minutes under stirring conditions, and continue stirring for 15 minutes to complete the pre-gelation process.

[0027] (4) Next, 0.01 g of chitosan was dissolved in 10 ml of acetic acid (2% concentration by mass), and added dropwise to the above-mentioned 3 pregels, and continued to stir for 30 min to form nanoparticles.

[0028] (5) Ultrasonic dispersion for 20 minutes to prevent aggregation, and centrifugation at 11,000 rpm for 40 minutes to freeze-dry to powder.

[0029] (6) Redissolve the above powder, add borneol and menthol, stir and mix, filter, and sterilize to obtain the eye patch.

[0030] (7) Soak the non-woven fabr...

Embodiment 2

[0033] (1) Dissolve 0.1g of sodium alginate and 0.01g of calcium chloride in 10ml of distilled water respectively.

[0034] (2) Dissolve 0.05 mg wolfberry extract, 0.1 mg cassia seed extract and 1 mg cyclosporine A in sodium alginate stock solution, and stir for 1 h.

[0035] (3) Add calcium chloride aqueous solution to the above 2 solutions within 30 minutes under stirring conditions, and continue stirring for 15 minutes to complete the pre-gelation process.

[0036] (4) Next, dissolve 0.01g of chitosan in 10ml of acetic acid (2%), and add dropwise to the above-mentioned 3 pregels, and continue to stir for 30min to form nanoparticles.

[0037] (5) Ultrasonic dispersion for 30 minutes to prevent aggregation, and centrifugation at 11,000 rpm for 40 minutes to freeze-dry to powder.

[0038] (6) Redissolve the above powder, add borneol and menthol, stir and mix, filter, and sterilize to obtain the eye patch.

[0039] (7) Put the non-woven fabric into the eye patch solution obta...

Embodiment 3

[0041] Eye patch nano-transdermal technology for improving dry eye syndrome

[0042] (1) Dissolve 0.1g of sodium alginate and 0.01g of calcium chloride in 10ml of distilled water respectively.

[0043] (2) Dissolve 0.05ug epidermal growth factor, 0.01mg lutein and 1mg vitamin A, 0.05mg wolfberry extract in sodium alginate stock solution, and stir for 1h.

[0044] (3) Add calcium chloride aqueous solution to the above 2 solutions within 30 minutes under stirring conditions, and continue stirring for 15 minutes to complete the pre-gelation process.

[0045] (4) Next, dissolve 0.02g of chitosan in 10ml of acetic acid (2%), and add dropwise to the above-mentioned 3 pregels, and continue to stir for 30min to form nanoparticles.

[0046] (5) Ultrasonic dispersion for 10 minutes to prevent aggregation, and centrifugation at 11,000 rpm for 40 minutes to freeze-dry to powder.

[0047] (6) Redissolve the above powder, add borneol and menthol, stir and mix, filter, and sterilize to obt...

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Abstract

The invention discloses an eye pad to improve dry eye syndrome via a nano transdermal technique and a preparation method thereof. The preparation method comprises the steps of dissolving sodium alginate and calcium chloride separately in distilled water; dissolving an effective composition in sodium alginate backup liquid, and stirring; adding calcium chloride solution into the solution under stirring, and continuing to stir to finish pre-gelling; dissolving chitosan in acetic acid, and adding into pre-gel to form nano particles; dispersing, and lyophilizing by centrifuging to obtain powder; redissolving the powder, adding borneol and menthol, mixing well, filtering, and disinfecting to obtain an eye pad liquid; soaking nonwoven cloth in the eye pad liquid to obtain the eye pad to alleviate dry eye syndrome. The chitosan-sodium alginate nanocarrier degradable in living things and having good biocompatibility is loaded to the eye pad; storage stability of the composition is improved, the effective ingredients therein can be released slowly, and the dry eye syndrome and visual fatigue can be further improved.

Description

technical field [0001] The invention relates to an eye patch, in particular to an eye patch and a preparation method thereof which are used for improving eye dryness by nano transdermal technology. Background technique [0002] Dry eye is an ocular surface disease in which the tear film is unstable during blinking due to various obstacles in the natural function and protection mechanism of the outer eye. The currently recognized causes of dry eye include reduced liquid tear production, abnormal mucus secretion, and meibomian gland dysfunction, which lead to absolute and relative lack of liquid components of the tear film, abnormal tear distribution on the ocular surface, and increased tear evaporation. A general term for a group of clinical diseases in which the cornea and conjunctiva are not properly moistened and the ocular surface epithelium becomes dry. Symptoms will be relieved by treatment, but it is difficult to cure completely. The common treatment method is to use ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K38/13A61K36/815A61K47/36A61K9/70A61P27/02A61P27/10A61P27/06A61P27/12A61K31/07A61K31/355A61K31/047A61K31/045
Inventor 魏坤胡方斌莫灿龙
Owner SOUTH CHINA UNIV OF TECH
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