Degradable medical antibacterial anti-seepage protective film and preparation method thereof
An antibacterial, anti-bacterial and protective film technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of uncontrollable degradation and poor hygroscopicity of pure chitosan dressings, so as to facilitate healing, avoid secondary injuries, and reduce infection Effect
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Embodiment 1
[0025] Step 1, pretreat the cellulose, place it in phosphate buffer and stir magnetically at 60°C for 30 minutes to disperse evenly, then add TEMPO, sodium chlorite, and sodium hypochlorite in sequence, and stir magnetically at 60°C overnight , the degree of oxidation was determined to be 8% by acid-base titration;
[0026] Step 2, mix the prepared 3% (g / mL) sodium alginate aqueous solution and 3% (g / mL) oxidized cellulose suspension in a ratio of 1:9, pour it into a mold to cast a film and dried at 25°C;
[0027] Step 3, soak the resulting material in 3% (g / mL) CaCl 2 In the ethanol / water (5:95, g / g) solution, let it stand for 12h to make it fully react, and dry at 25°C;
[0028] Step 4, soak the above film in a chitosan solution with a molecular weight of 4% (g / mL) for 24 hours to make the calcium alginate in the film and the carboxyl group in the oxidized cellulose and the amine on the surface of the chitosan The base was fully reacted and dried at 25°C to form a film. ...
Embodiment 2
[0031] Step 1, the cellulose is pretreated with CCl 4 As an inert catalytic enzyme, NO 2 (N 2 o 4 ) is treated as an oxidizing agent to oxidize the hydroxyl groups on its surface into carboxyl groups, and after reacting overnight, measure its oxidation degree by acid-base titration method to be 30%;
[0032] Step 2, mixing the prepared 0.5% sodium alginate aqueous solution and 0.5% oxidized cellulose suspension in a ratio of 10:1, pouring it into a mold to cast a film and drying at 60°C;
[0033] Step 3, soak the resulting material in 0.1% CaCl 2 In the ethanol / water (1:99, g / g) solution, let it stand for 48h to make it fully react, and make it dry at 60°C;
[0034] Step 4, soak the above film in a chitosan solution with a molecular weight of 0.5% and a molecular weight of 400,000 for 72 hours to fully react the carboxyl groups in the calcium alginate and oxidized cellulose in the film with the amine groups on the surface of the chitosan. C to dry into a film.
Embodiment 3
[0036] Step 1, pretreat the cellulose, place it in phosphate buffer and stir magnetically at 60°C for 30 minutes to disperse evenly, then add TEMPO, sodium chlorite, and sodium hypochlorite in sequence, and stir magnetically at 60°C overnight , the degree of oxidation was determined to be 8% by acid-base titration;
[0037] Step 2, mix the prepared 3% sodium alginate aqueous solution and 3% oxidized cellulose suspension in a mass ratio of 3:7, pour it into a mold to cast a film and dry it at 25°C;
[0038] Step 3, soak the resulting material in 3% CaCl 2 In the ethanol / water (1:1, g / g) solution, let it stand for 24h to make it fully react, and make it dry at 60°C;
[0039] Step 4, soak the above film in a chitosan solution with a concentration of 20% and a molecular weight of 220,000 for 0.5h so that the carboxyl or aldehyde groups in the calcium alginate in the film and the oxidized cellulose and the amine groups on the surface of the chitosan are fully React and dry at 60°...
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