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Novel aspirin two-dimensional nano drug-loading and sustained-release system

A technology of aspirin and drug loading, which is applied in the field of medicine to achieve the effects of improving drug burst release, avoiding drug burst release, and prolonging drug efficacy

Inactive Publication Date: 2019-06-25
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these sustained-release systems have some defects in varying degrees in the sustained-release effect of the target drug.

Method used

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  • Novel aspirin two-dimensional nano drug-loading and sustained-release system
  • Novel aspirin two-dimensional nano drug-loading and sustained-release system
  • Novel aspirin two-dimensional nano drug-loading and sustained-release system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of Ni-Ti-LDHs

[0031] Nickel nitrate hexahydrate (Ni(NO 3 ) 2 ·6H 2 O), tetrabutyl titanate (Ti(OC 4 h 9 ) 4 ), triethanolamine (N(C 2 h 4 Oh) 3 ), in molar ratio n(Ni 2+ ):n(Ti 4+ ): n(TEA)=5:1:6 was added to the reactor, and in the first step, nitrogen gas was fed into the three-necked flask to drive away the air in the bottle, and 7.5mL of absolute ethanol and 1.390gTi(OC 4 h 9 ) 4 In the flask, stir evenly at 60°C; in the second step, add 3.620g N(C 2 h 4 Oh) 3 , continue to stir evenly; the third step adds 5.930g nickel nitrate (Ni(NO 3 ) 2 ·6H 2O) and 40mL deionized water. Finally use 0.25mol L -1 Sodium hydroxide solution, adjust the pH value of the solution between 8-9. Raise the temperature to 100°C, reflux and condense the reaction system for 45 hours, all the above operations are under N 2 Finished under protection. Suction filter the obtained green mixed solution, wash with a small amount of absolute ethanol to remove the o...

Embodiment 2

[0041] The preparation of Ni-Ti-LDHs and the preparation of Ni-Ti-LDHs nanosheets were all prepared according to the method in Example 1.

[0042] Aspirin-LDHs complex (n 阿司匹林 / n LDHs =1:2) Preparation

[0043] Aspirin was mixed with Ni-Ti-LDHs sample by molar ratio n 阿司匹林 / n LDHs =1:2 for intercalation recombination. First, 20 mL of deionized water was directly added into the Erlenmeyer flask containing 0.3768 g of LDHs, heated and stirred at 60 ° C, 0.050 g of aspirin was added to the above solution and heated and stirred at 70 ° C for 6 h, then stood for 24 h, and then pumped Filter, wash with ice water, and dry under vacuum at 60°C.

[0044] Aspirin-LDHs nanosheet complex (n 阿司匹林 :n LDHs纳米片 =1:2) Preparation

[0045] The Ni-Ti-LDHs nanosheets were peeled off with the aid of formamide ultrasound, and the sol containing LDHs nanosheets was distilled under reduced pressure at 90°C to remove part of the formamide, so that the nanosheets were precipitated, so that the...

Embodiment 3

[0049] The preparation of Ni-Ti-LDHs and the preparation of Ni-Ti-LDHs nanosheets were all prepared according to the method in Example 1.

[0050] Aspirin-LDHs complex (n 阿司匹林 / n LDHs =1:5) preparation

[0051] Aspirin was mixed with Ni-Ti-LDHs sample by molar ratio n 阿司匹林 / n LDHs =1:5 for intercalation compounding. First, 20 mL of deionized water was directly added into the Erlenmeyer flask containing 0.9421 g of LDHs, heated and stirred at 60 ° C, 0.05 g of aspirin was added to the above solution and heated and stirred at 80 ° C for 7 h, then stood still for 25 h, and then pumped After filtration, washing with ice water, vacuum drying at 80°C.

[0052] Aspirin-LDHs nanosheet complex (n 阿司匹林 :n LDHs纳米片 =1:5) preparation

[0053] The Ni-Ti-LDHs nanosheets were peeled off with formamide ultrasonic assistance, and the sol containing LDHs nanosheets was distilled under reduced pressure at 90°C to remove part of the formamide, so that the nanosheets were precipitated to ...

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Abstract

The invention relates to a double metal hydroxide (Layered Double Hydroxides, LDHs) carrier material having a two-dimensional sheet structure and a preparation method thereof. The system is characterized by a two-dimensional double metal hydroxide having an ultra-large specific surface area, an abundant hydroxyl group on the surface can interact with aspirin having a carbonyl group. and the loading and sustained release of the two-dimensional double hydroxide to aspirin is achieved, which can prolong the release of aspirin. The preparation method has the advantage of simple process, can uniformly combine two-dimensional double metal hydroxide with aspirin, achieves the slow release effect, and expands an application of nanomaterials, especially two-dimensional materials in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a high-efficiency, stable and slow-release drug-carrying system constructed with a double metal hydroxide having a two-dimensional sheet structure as a carrier and a preparation method. Background technique [0002] The drug release system is a new route of administration, which can selectively act on the lesion, and precisely control or slow release as needed. This system can maintain the effective concentration of the drug in the blood and prolong the drug action time. Therefore, the drug can achieve the best therapeutic effect, reduce systemic toxicity, fully meet the clinical needs, and provide a strong guarantee for the prevention and treatment of diseases for the majority of patients; while the traditional way of administration (oral or injection) often makes the drug concentration in the blood fluctuate greatly , The utilization rate, safety and effectiveness of the dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K31/616A61K47/52A61P29/00
Inventor 胡丽芳王丽平何杰朱继超刘柳陈小平
Owner ANHUI UNIV OF SCI & TECH
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