A porous anti-tumor bone repair bifunctional composite scaffold modified by dopamine and embedded with organic matter and its preparation method
A nano-powder and composite scaffold technology, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, drug combinations, etc., to achieve good photothermal effects, improve dispersibility, and improve compressive strength
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Embodiment 1
[0043] The preparation method of the dopamine-modified nano-powder and embedded organic matter porous anti-tumor bone repair bifunctional composite scaffold described in Example 1 comprises the following steps:
[0044] (1) Add 8 mL of absolute ethanol to 18 mL of deionized water (the volume ratio of the absolute ethanol to water is 4:9) to obtain an ethanol solution, and add 0.6 mL of ammonia water (mass percentage concentration is 28 wt %) to the ethanol solution , stirred evenly at room temperature to obtain a mixture; 0.02g dopamine hydrochloride was added into 2mL water and mixed uniformly to obtain a dopamine hydrochloride solution (concentration is 10mg / mL), and the dopamine hydrochloride solution was added in the mixture (the volume ratio of ammonia water and dopamine hydrochloride solution was 3 :10, the volume ratio of dopamine hydrochloride solution and absolute ethanol is 1:4), under the 600rpm rotating speed, continue to stir violently 0.5h, stir evenly, obtain mix...
Embodiment 2
[0056] The preparation method of the porous anti-tumor bone repair bifunctional composite scaffold modified by dopamine nano powder and embedded with organic matter described in Example 2 comprises the following steps:
[0057] (1) Add 6 mL of isopropanol to 18 mL of deionized water (the volume ratio of the isopropanol to water is 3:9) to obtain a solution of isopropanol, and add 0.6 mL of ammonia water (mass percentage concentration) to the solution of isopropanol 29wt%), stirred at normal temperature to obtain a mixture; 0.06g dopamine hydrochloride was added into 2mL water and mixed uniformly to obtain a dopamine hydrochloride solution (concentration is 30mg / mL), and the dopamine hydrochloride solution was added in the mixture (amount of ammonia water and dopamine hydrochloride solution The volume ratio is 3:10, the volume ratio of dopamine hydrochloride solution and isopropanol is 1:4), under the 600rpm rotating speed, continue to vigorously stir for 0.5h, stir evenly, obta...
Embodiment 3
[0069] The preparation method of the dopamine-modified nano-powder and embedded organic matter porous anti-tumor bone repair bifunctional composite scaffold described in Example 3 comprises the following steps:
[0070] (1) Add 12mL of n-propanol to 18mL of deionized water (the volume ratio of said n-propanol to water is 6:9) to obtain a n-propanol solution, and add 0.6mL of ammonia water (mass percentage concentration) to the n-propanol solution 30wt%), stirred evenly at room temperature to obtain a mixture; 0.1g dopamine hydrochloride was added into 2mL water and mixed uniformly to obtain a dopamine hydrochloride solution (concentration is 50mg / mL), and the dopamine hydrochloride solution was added in the mixture (amount of ammonia water and dopamine hydrochloride solution The volume ratio is 3:10, the volume ratio of dopamine hydrochloride solution and n-propanol is 1:4), under the 600rpm rotating speed, continue to vigorously stir for 0.5h, stir evenly, and obtain the mixed...
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