Fluorescent carbon quantum dot based on biomass and preparation method and application thereof

A technology of carbon quantum dots and biomass, applied in fluorescence/phosphorescence, chemical instruments and methods, preparations for in vivo experiments, etc., can solve problems such as insufficient penetration depth, inability to apply light to the field of diagnosis and treatment, and short wavelength, etc., to achieve Wide range of raw material sources, excellent low toxicity, and simple preparation methods

Inactive Publication Date: 2019-06-28
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many carbon sources that can be used to prepare carbon dots. Compared with synthetic materials, biomass materials have a wide range of sources and low prices. However, at this stage, most of the carbon dots that use biomass materials as carbon sources are concentrated in the blue light area, such as Chang et al. used green tea leaves as carbon source to prepare carbon dots [Journal of Materials Chemistry B, 2013, 1, 1774-1781]; Dong et al. used soybean milk as carbon source to prepare carbon dots for electrocatalytic oxygen reduction reaction [ChemistryCommunication, 2012 ,48,9367-9369]; Yu et al. used honey as a carbon source to prepare carbon dots for multicolor cell imaging and homogeneous catalysis [Advanced Science,2015,2,1500002], the above single blue fluorescent carbon dots , the wavelength is too short and the penetration depth is not enough to be used in the field of photodiagnosis

Method used

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  • Fluorescent carbon quantum dot based on biomass and preparation method and application thereof
  • Fluorescent carbon quantum dot based on biomass and preparation method and application thereof
  • Fluorescent carbon quantum dot based on biomass and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of the fluorescent carbon quantum dot based on biomass comprises the steps:

[0042] Weigh 30 mg of pheophytin powder, add 30 mL of N,N-dimethylformamide, ultrasonically oscillate for 30 minutes, transfer to a microwave digestion reactor, heat at 150°C for 30 minutes under 500W power, and wait for the solution to cool to room temperature , filtered with a filter membrane with a pore size of 0.22 μm, and then dialyzed through a dialysis bag with a molecular weight cut-off of 3500 for 48 hours to remove N,N-dimethylformamide to obtain an aqueous solution of carbon quantum dots, which was finally freeze-dried for 36- After 48h, a biomass-based fluorescent carbon quantum dot solid was obtained.

[0043] figure 1 It is a high-resolution transmission electron microscope image of the fluorescent carbon quantum dots corresponding to Example 1, and the results show that the fluorescent carbon quantum dots made of pheophytin are uniformly dispersed spheric...

Embodiment 2

[0047] The preparation method of the fluorescent carbon quantum dot based on biomass comprises the steps:

[0048] Weigh 30mg of arbutin powder, add 30mL N,N-dimethylformamide, ultrasonically oscillate for 30 minutes, then transfer to a microwave digestion reactor, heat at 150°C for 30 minutes under 500W power, and wait for the solution to cool to room temperature , filtered with a filter membrane with a pore size of 0.22 μm, and then dialyzed through a dialysis bag with a molecular weight cut-off of 3500 for 48 hours to remove N,N-dimethylformamide to obtain an aqueous solution of carbon quantum dots, which was finally freeze-dried for 36- After 48 hours, a biomass-based fluorescent carbon quantum dot solid was obtained, and the structure and performance of the fluorescent carbon quantum dot were similar to those of Example 1.

Embodiment 3

[0050] The preparation method of the fluorescent carbon quantum dot based on biomass comprises the steps:

[0051] Weigh 30 mg of chestnut peptide powder, add 30 mL of N,N-dimethylformamide, ultrasonically oscillate for 30 minutes, transfer to a microwave digestion reactor, heat at 150°C for 30 minutes under 500W power, and wait for the solution to cool to room temperature. Filter with a filter membrane with a pore size of 0.22 μm, and then dialyze through a dialysis bag with a molecular weight cut-off of 3500 for 48 hours to remove N,N-dimethylformamide to obtain an aqueous solution of carbon quantum dots, which is finally freeze-dried for 36-48 hours by a lyophilizer Finally, the biomass-based fluorescent carbon quantum dot solid was obtained, and the structure and performance of the fluorescent carbon quantum dot were similar to those in Example 1.

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Abstract

The invention discloses a fluorescent carbon quantum dot based on biomass. The fluorescent carbon quantum dot is characterized in that raw materials of the fluorescent carbon quantum dot comprise thebiomass, and the biomass is selected from one or more of phaeophytin, arbutin and chestnut peptide. The fluorescent carbon quantum dot has an excitation peak in a near-infrared region, emits red fluorescence, can effectively generate singlet oxygen and overtemperature, and can be well used for near-infrared imaging and photodynamic and photothermal therapy. The invention also discloses a preparation method and application of the fluorescent carbon quantum dot.

Description

technical field [0001] The invention relates to the technical field of carbon quantum dots. More specifically, it relates to a biomass-based fluorescent carbon quantum dot and its preparation method and application. Background technique [0002] Carbon quantum dots, referred to as carbon dots, are a kind of carbon nanomaterials that have attracted widespread attention in recent years. , long circulation in the body and good passive targeting of tumors, etc., which make it have broad application prospects in photocatalysis, photoelectric conversion, biological imaging and detection, and photodiagnosis. Compared with semiconductor quantum dots, carbon dots do not contain other toxic heavy metal elements; compared with traditional organic dyes, carbon dots have better photostability, which makes carbon dot materials have attractive prospects in the above fields. [0003] As a photodiagnostic agent, carbon dots can accurately reach the lesion area through passive targeting, de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00A61K41/00A61K49/00A61P35/00G01N21/64
Inventor 文咏梅葛介超汪鹏飞刘卫敏
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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