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Preparation method for slow-release polysaccharide-based hollow capsule

A hollow capsule and slow-release technology, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve problems such as poor gastric buoyancy, high sol viscosity, and poor slow-release performance, and reduce The effect of sol viscosity, increasing solid content, and long residence time

Pending Publication Date: 2019-07-02
常州市顺旭商贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main technical problem to be solved by the present invention is that the current common plant polysaccharide-based capsule materials have strong hygroscopicity leading to poor storage stability, high sol viscosity leading to difficult molding and poor slow-release performance, and poor gastric buoyancy, which cannot effectively extend the content. The retention time of the substance in the gastric juice cannot obtain the defect of good gastric sustained-release performance, and a preparation method of a sustained-release polysaccharide-based hollow capsule is provided

Method used

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  • Preparation method for slow-release polysaccharide-based hollow capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Precipitate preparation:

[0029] Mix konjac glucomannan and water into a beaker with a mass ratio of 1:5, let it stand for swelling for 30 minutes, then add 30% hydrogen peroxide with a mass fraction of 3 times the mass of konjac glucomannan to the beaker, and stir the oxidation reaction After 40 min, absolute ethanol with the same quality as water was added, allowed to stand and separated to obtain a precipitate.

[0030] Preparation of modified konjac glucomannan:

[0031] Heat the soybean protein solution with a mass fraction of 30% to 75°C, heat-preserve it for 15 minutes, mix the heat-treated soybean protein solution and the above-mentioned precipitate at a mass ratio of 5:1 and put them into the reaction kettle, and then feed the reaction Add sodium polyphosphate with a mass of 1% of the sediment in the kettle, and stir for 30 minutes; after the above stirring reaction is completed, add anhydrous ethanol equal in volume to the soybean protein solution to the kettl...

Embodiment 2

[0037] Precipitate preparation:

[0038] Mix konjac glucomannan and water into a beaker at a mass ratio of 1:5, let it stand for swelling for 35 minutes, then add 30% hydrogen peroxide with a mass fraction of 4 times the mass of konjac glucomannan to the beaker, and stir the oxidation reaction After 45 minutes, absolute ethanol with the same mass as water was added, allowed to stand and separated to obtain a precipitate.

[0039] Preparation of modified konjac glucomannan:

[0040] Heat the soybean protein solution with a mass fraction of 30% to 77°C, heat-preserve it for 18 minutes, then mix the heat-treated soybean protein solution and the above-mentioned precipitate at a mass ratio of 5:1 and put them into the reactor, and then feed the reaction Add sodium polyphosphate with a mass of 1% of the sediment in the kettle, and stir for 35 minutes; after the above stirring reaction is completed, add anhydrous ethanol equal in volume to the soybean protein solution to the kettle,...

Embodiment 3

[0046] Precipitate preparation:

[0047] Mix konjac glucomannan and water into a beaker at a mass ratio of 1:5, let it stand for swelling for 40 minutes, then add 30% hydrogen peroxide with a mass fraction of 5 times the mass of konjac glucomannan into the beaker, and stir the oxidation reaction After 50 min, absolute ethanol with the same mass as water was added, allowed to stand and separated to obtain a precipitate.

[0048] Preparation of modified konjac glucomannan:

[0049] Heat the soybean protein solution with a mass fraction of 30% to 80°C, heat-preserve it for 20 minutes, then mix the heat-treated soybean protein solution and the above-mentioned precipitate at a mass ratio of 5:1 and put them into the reaction kettle, and then feed the reaction Add sodium polyphosphate with 2% of the mass of the precipitate in the kettle, and stir for 40 minutes; after the above stirring reaction is completed, add anhydrous ethanol equal in volume to the soybean protein solution int...

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Abstract

The invention belongs to the technical field of preparation of medical materials, and specifically relates to a preparation method for a slow-release polysaccharide-based hollow capsule. According tothe preparation method, konjac glucomannan is utilized as a raw material to obtain modified konjac glucomannan, the konjac glucomannan is blended with polysaccharide algin and sodium carboxymethylcellulose, then glycerine and water mixed gel are added to obtain a mixed slurry, and the slow-release polysaccharide-based hollow capsule is finally prepared by calcification crosslinking in two times. The preparation method firstly oxidizes polysaccharide konjac glucomannan to break the molecular weight of polysaccharide, thereby reducing the viscosity of sol and a solid content thereof is increased, then crosslinking modification is performed on the oxidized konjac glucomannan by soy protein under the action of phosphate, the stability is improved, so that the detention time in a gastric juiceis long, then a complex reaction is performed by utilizing calcium ions and a modified konjac glucomannan surface and a chelating group to form an insoluble complex, the tolerance of the capsule in the gastric juice is improved, the molding integrity of the capsule is improved by two calcification treatments, and application prospects are broad.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical materials, and in particular relates to a preparation method of a sustained-release polysaccharide-based hollow capsule. Background technique [0002] Capsules are widely used in the pharmaceutical, health care and functional food industries, and are one of the most commonly used dosage forms for pharmaceuticals and functional foods. Empty capsules are usually composed of a cap and a body capsule shell prepared from gelatin, glycerin and other auxiliary materials. The hollow capsule shell is the main outer packaging material for filling medicine and health food, and it is taken into the body together with the endocytosis, which reduces the trouble of entrance and increases the curative effect. The capsule shell keeps the drug active, protected from sunlight, air, light, etc. in nature, and can also prevent some drugs from being released at inappropriate locations and causing advers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/36A61K47/38A61K47/42
CPCA61K9/4816A61K9/4825
Inventor 殷小祥
Owner 常州市顺旭商贸有限公司