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A CT visualization and mucoadhesive dual-function microcapsules and its preparation method and application

A dual-function, microcapsule technology, applied in the field of biomedical materials, can solve problems such as the inability to observe and evaluate the retention and colonization of exogenous probiotics in real time, the short retention time in the intestinal tract, and affect the therapeutic effect, etc. Effect of effective colonization and growth, efficient mucoadhesive properties

Active Publication Date: 2022-02-22
天益健康科学研究院(镇江)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, microcapsules, as probiotic carriers, often lead to low colonization efficiency of exogenous probiotics due to lack of effective adhesion and short intestinal retention time during oral administration, seriously affecting their therapeutic effect
At the same time, due to the lack of effective non-invasive monitoring methods, it is impossible to observe and evaluate the retention and colonization of exogenous probiotics in the intestinal tract in real time

Method used

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  • A CT visualization and mucoadhesive dual-function microcapsules and its preparation method and application
  • A CT visualization and mucoadhesive dual-function microcapsules and its preparation method and application
  • A CT visualization and mucoadhesive dual-function microcapsules and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of low-catechol modified multifunctional microcapsules:

[0038] (1) 1.625 mmol of chitosan was dissolved in 0.97% glacial acetic acid solution, and the pH was adjusted to 4.5.

[0039] (2) Dissolve 3.25mmol 3,4-dihydroxyphenylalanine in 5mL double distilled water, slowly add into the chitosan solution obtained in (1) and keep stirring.

[0040] (3) Dissolve 3.245 mmol of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride in 50 mL of double distilled water and absolute ethanol (1:1) mixed solution, dropwise Slowly add the rapidly stirred 3,4-dihydroxyphenylalanine and chitosan mixed solution obtained in (2), vigorously stir at room temperature for 4 hours, and adjust the pH to 5.0.

[0041] (4) The mixed solution was dialyzed in the dark using a dialysis bag (molecular weight cut-off: 2000), dialyzed in double distilled water (pH5.0) for 2 days, PBS for 4 hours, and double distilled water for 1 day. Store at -20°C after lyophilization.

[0...

Embodiment 2

[0044] A kind of preparation method of the multifunctional microcapsule modified by medium catechol:

[0045] (1) 3.25 mmol of chitosan was dissolved in 0.97% glacial acetic acid solution, and the pH was adjusted to 4.5.

[0046] (2) 3.25 mmol of 3,4-dihydroxyphenylalanine was stirred and dissolved in 5 mL of double distilled water, slowly added into the chitosan solution obtained in (1) and kept stirring.

[0047] (3) Dissolve 3.245 mmol of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride in 50 mL of double distilled water and absolute ethanol (1:1) mixed solution, dropwise Slowly add the rapidly stirred 3,4-dihydroxyphenylalanine and chitosan mixed solution obtained in (2), vigorously stir at room temperature for 4 hours, and adjust the pH to 5.0.

[0048] (4) The mixed solution uses a dialysis bag with a molecular weight cut-off of 2000, protected from light, dialyzed with double distilled water, pH 5.0, dialyzed for 2 days, PBS for 4 hours, and double distilled ...

Embodiment 3

[0051] A preparation method of multifunctional microcapsules modified with high catechol:

[0052] (1) 3.25 mmol of chitosan was dissolved in 0.97% glacial acetic acid solution, and the pH was adjusted to 4.5.

[0053] (2) 3.25 mmol of 3,4-dihydroxyphenylalanine was stirred and dissolved in 5 mL of double distilled water, slowly added into the chitosan solution obtained in (1) and kept stirring.

[0054] (3) Dissolve 6.49 mmol of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride in 50 mL of double distilled water and absolute ethanol (1:1) mixed solution, dropwise Slowly add the mixed solution of 3,4-dihydroxyphenylalanine and chitosan obtained in (2) with rapid stirring, stir vigorously at room temperature for 4 hours, and adjust the pH to 5.0.

[0055] (4) The mixed solution uses a dialysis bag with a molecular weight cut-off of 2000, protected from light, dialyzed with double distilled water, pH 5.0, dialyzed for 2 days, PBS for 4 hours, and double distilled water...

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Abstract

The invention discloses a CT visualization and mucoadhesive dual-function microcapsule, its preparation method and its application. A catechol-modified chitosan modified by catechol is prepared by a chemical grafting method; a low-concentration alginic acid is then used and sodium sulfate solution as the spray liquid, and barium chloride solution as the receiving liquid to prepare alginic acid microspheres containing barium sulfate by one-step electrostatic spraying method; Surface coating to obtain chitosan / alginic acid microcapsule complex; mixing with trisodium citrate solution to obtain microcapsules. The microcapsule prepared by the invention has excellent mucoadhesive properties and dual functions of CT imaging, and has application in the preparation of oral pharmaceutical preparations, oral nutrient preparations or oral probiotic preparations.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a CT visualization and mucoadhesive dual-function microcapsule, a preparation method and an application thereof. Background technique [0002] Microcapsules are microscopic containers or packages with polymeric walls. Its size generally ranges from 5-200 μm, and its shape varies, depending on the raw material and preparation method. Among them, the embedded material is called the core material, and the material that embeds the core material to achieve microencapsulation is called the wall material. The preparation methods of microcapsules mainly include spray drying, in-situ polymerization, emulsion crosslinking and organic solvent phase separation. [0003] In recent years, microcapsule preparation technology and application fields have developed rapidly. The network structure wall of the microcapsules can stably and slowly release the drug, alleviate the damage of the dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K9/62A61K47/10A61K47/36A61K35/741A61K35/747A61K31/341
CPCA61K49/0404A61K9/5036A61K9/5015A61K35/741A61K35/747A61K31/341
Inventor 杜凤移边高瑞吴云超张苗苗贾长生李珮铷
Owner 天益健康科学研究院(镇江)有限公司
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