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Preparation method of ganciclovir powder injection and filter press used by same

A technology of clovir powder injection and ganciclovir, which is applied in the field of drug production, can solve the problems of inconvenient application, cumbersome operation, and inconvenient disassembly of filter cloth, and achieve the effects of easy collection, simple process, and easy popularization and application

Active Publication Date: 2019-07-26
南京瑄宇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When collecting and cleaning the filtered filter cake, the filter plate needs to be removed from the filter press first, and then the filter cloth can be disassembled before the action can be performed. The operation is cumbersome and the application is inconvenient; in addition, after a period of use, the filter cloth It needs to be cleaned and replaced, and the disassembly of the filter cloth is inconvenient

Method used

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  • Preparation method of ganciclovir powder injection and filter press used by same
  • Preparation method of ganciclovir powder injection and filter press used by same
  • Preparation method of ganciclovir powder injection and filter press used by same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of ganciclovir powder injection, is characterized in that, comprises the steps:

[0044] (1) primary refining: adding sodium hydroxide in the crude product of ganciclovir, the mass ratio of the crude product of ganciclovir and sodium hydroxide is 5:1, then adding ethanol solution, the crude product of ganciclovir And the quality of sodium hydroxide and the ratio of the quality with the ethanol solution are 1:8, after stirring and dissolving, filter with gac, obtain filtrate 1, and filtrate 1 evaporates and purifies, obtains solution 1;

[0045] (2) Secondary refining: Put solution one and DMF into the autoclave together, the volume ratio of DMF and solution one is 10:1, heat up to 100°C rapidly, stir for 2h, then cool to 60°C, use Press the filter press to filter, collect the filtrate 2, continue to cool the filtrate 2 to 0° C. and keep it warm for 5 hours, then centrifuge to obtain the high-quality ganciclovir;

[0046] (3) Preparation of medicina...

Embodiment 2

[0058] A preparation method of ganciclovir powder injection, is characterized in that, comprises the steps:

[0059] (1) primary refining: adding sodium hydroxide in the crude product of ganciclovir, the mass ratio of the crude product of ganciclovir and sodium hydroxide is 8:1, then adding ethanol solution, the crude product of ganciclovir And the quality of sodium hydroxide and the ratio of the quality with ethanol solution are 1:10, after stirring and dissolving, filter with gac, obtain filtrate 1, filtrate 1 evaporates and purifies, obtains solution 1;

[0060] (2) Secondary refining: put solution 1 and DMSO into the autoclave together, the volume ratio of DMSO and solution 1 is 10:1, rapidly heat up to 100°C, stir for 2h, then cool to 60°C, use Press the filter press to filter, collect the filtrate 2, continue to cool the filtrate 2 to 0° C. and keep it warm for 5 hours, then centrifuge to obtain the high-quality ganciclovir;

[0061](3) Preparation of medicinal liquid: ...

Embodiment 3

[0065] A preparation method of ganciclovir powder injection, is characterized in that, comprises the steps:

[0066] (1) primary refining: adding sodium hydroxide in the crude product of ganciclovir, the mass ratio of the crude product of ganciclovir and sodium hydroxide is 8:1, then adding ethanol solution, the crude product of ganciclovir And the quality of sodium hydroxide and the ratio with the quality of ethanol solution are 1:12, after stirring and dissolving, filter with gac, obtain filtrate 1, filtrate 1 evaporates and purifies, obtains solution 1;

[0067] (2) Secondary refining: put solution 1 and the composition of DMF and DMSO into the autoclave, the volume ratio of the composition of DMF and DMSO to solution 1 is 10:1, and rapidly heat up to 100°C, Stir for 2 hours, then cool to 60°C, press filter with a filter press, collect the filtrate 2, continue to cool the filtrate 2 to 0°C and keep it warm for 5 hours, then centrifuge to obtain the high-quality ganciclovir;...

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Abstract

The invention discloses a preparation method of a ganciclovir powder injection and a filter press used by the same, and belongs to the technical field of medicine production. The preparation method includes refining crude ganciclovir twice, evenly mixing the refined ganciclovir with a filtered glycerin sodium chloride aqueous solution and finally freeze-drying the mixture to obtain the ganciclovirpowder injection. The filter press comprises a bracket, a thrust plate, a press plate, a filter plate, a filter cloth and a driving component, and the filter cloth and the filter plate are separatedand installed on a frame body made of polypropylene. The upper and lower edges of the frame body are respectively provided with a deep clamping groove and a shallow clamping groove corresponding to anupper guide rod and a lower guide rod, installation and removal can be performed on the upper guide rod and the lower guide rod conveniently, a first sealing assembly is respectively arranged on thefilter plates on two sides of the frame body, and a second sealing assembly is respectively arranged on the opposite sides of the two adjacent filter plates. The ganciclovir powder injection has relatively less impurity content, and can improve the effect of the ganciclovir powder injection. The filter press facilitates collection of a filtrate and a filter cake and cleaning and replacement of thefilter cloth.

Description

technical field [0001] The invention relates to the technical field of medicine production, in particular to a preparation method of ganciclovir powder injection and a filter press used therein. Background technique [0002] Cytomegalovirus (CMV) belongs to the herpes virus family. The virus is in a resting state in individuals with normal immune function, but when the immune function is impaired (such as AIDS patients, organ transplantation and bone marrow transplantation, receiving immunosuppressive patients, etc.), the virus can cause serious illness. CMV infection occurs through direct contact with infected tissue or bodily fluids (such as saliva, blood, or urine). The routes of transmission are very extensive, and the most common ones are intrauterine, cervical secretion or breast milk transmission, close contact with young children in the intensive care unit, and sexual contact. The most common condition of CMV in AIDS patients is CMV retinitis, an eye infection that...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/522A61K47/10A61P31/22B01D25/12
CPCA61K9/0019A61K9/19A61K31/522A61K47/10A61P31/22B01D25/12
Inventor 王燕红汪余胜
Owner 南京瑄宇医药科技有限公司
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