A kind of peg-40 polyglycerol-10 oleate and preparation method
A PEG-40, polyglycerol technology, applied in chemical instruments and methods, transportation and packaging, dissolution and other directions, can solve the problems of loss of environment for adsorption products, incomplete reaction of materials, incompatibility, etc., to achieve good transparency, delicate products, Excellent performance
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[0024] A preparation method of PEG-40 polyglycerol-10 oleate, comprising the steps:
[0025] 1) etherification reaction of polyglycerol-10 and oleic acid under the conditions of antioxidant, catalyst potassium hydroxide and cocatalyst silica, and the etherification reaction temperature is 120-180 ° C;
[0026] Polyglycerol-10: technical requirements hydroxyl value 888mgkoH / g, heavy metal ≤ 10mg / GK, color less than iron cobalt colorimetric No. 2; oleic acid: technical requirements acid value 196-203mgkoH / g, iodine value 80-100gl / 100g, The color is smaller than the iron-cobalt color No. 2 color. After accurately weighing the polyglycerol-10, oleic acid, antioxidant BHT, catalyst potassium hydroxide and co-catalyst silica, they were pumped into the stainless steel reaction kettle with a stainless steel vacuum pump.
[0027] 2) When the material is heated to 180°C, add PEG-40, esterify under the protection of carbon dioxide gas, and react at a temperature of 180-250°C for 3-8 hou...
Embodiment 1
[0032] A preparation method of PEG-40 polyglycerol-10 oleate, specifically as follows:
[0033] 1) Ingredients: In parts by weight, 240 parts of polyglycerol-10, technical requirements of hydroxyl value 888mgkoH / g, heavy metals ≤ 2mg / GK, color less than iron cobalt colorimetry No. 2; 150 parts of oleic acid, technical requirements of acid value 196-203mgkoH / g, iodine value 80-100gI / 100g, the color is less than the color of No. 2 iron-cobalt color; 0.001 part of antioxidant BHT; 0.05 part of catalyst potassium hydroxide and 0.05 part of co-catalyst silica, the above ingredients are accurate The weighing is pumped into a stainless steel reaction kettle with a stainless steel vacuum pump.
[0034] 2) Etherification: The etherification temperature is 120-180°C.
[0035] 3) Esterification: when the temperature of the material reaches 180°C, add 630 parts of PEG-40, the model is polyethylene glycol 1500, and the heavy metal is less than 10mg / GK pharmaceutical grade, pumped into the...
Embodiment 2
[0040] A preparation method of PEG-40 polyglycerol-10 oleate, specifically as follows:
[0041] 1) Ingredients: In parts by weight, 260 parts of polyglycerol-10, technical requirements of hydroxyl value 888mgkoH / g, heavy metals ≤ 2mg / GK, color less than iron cobalt colorimetric No. 2 color; 160 parts of oleic acid, technical requirements of acid value 196-203mgkoH / g, iodine value 80-100gl / 100g, color less than iron-cobalt colorimetric No. 2; antioxidant BHT 0.001 part; catalyst potassium hydroxide 0.05 part and co-catalyst silica 0.05 part, the above-mentioned The ingredients are accurately weighed and pumped into the stainless steel reaction kettle with a stainless steel vacuum pump.
[0042] 2) Etherification: The etherification temperature is 120-180°C.
[0043] 3) Esterification: when the temperature of the material reaches 180°C, add 600 parts of PEG-40, the model is polyethylene glycol 2000, and the heavy metal is less than 10mg / GK pharmaceutical grade, pumped into the ...
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