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Preparation method of amino acid modified microspheres and product thereof

A technology of amino acids and amino acids, applied in the field of preparation of amino acid modified microspheres, can solve the problems of difficult catalyst recovery, harsh reaction conditions, expensive catalysts, etc., and achieve the effects of easy industrial application, mild preparation process conditions, and easily available sources.

Active Publication Date: 2019-08-16
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The study found that the traditional reaction of introducing a planar chiral structure into a ferrocene structure requires expensive catalysts and harsh reaction conditions, requiring equivalent lithium reagents, chiral bases, etc. The chiral structure is introduced into the ferrocene framework, and the conditions are relatively mild, but because most of them are homogeneous catalysts, it brings certain difficulties to the recovery of the catalyst after the reaction
At the same time, the study found that amino acid ligands can be grafted on the surface of polystyrene microspheres, but the microspheres will swell in organic solvents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] An amino acid modified microsphere is prepared according to the following steps:

[0023] (1) Put 0.07 g of Span-60 and 0.03 g of Tween-20 in a three-necked flask, add 12 ml of n-heptane, set the stirring rate to 325 rpm, and disperse evenly;

[0024] (2) Gradually add 0.07 g of methacrylamide, 0.15 g of amino acid ligand, 0.4 g of N, N’-methylenebisacrylamide, and 1.76 g of formamide and stir until a transparent solution;

[0025] (3) Add 0.07 g of azobisisobutyronitrile to the solution in step (2) to dissolve, then feed nitrogen gas while pumping air with a vacuum pump to remove the air in the system, so that the reaction process is in the state of nitrogen protection;

[0026] (4) Raise the reaction temperature to 70 degrees, and the stirring rate is 300-400 rpm. After stirring for 4 hours, filter to obtain white particles, wash them with ethanol, put them in an oven at 70 degrees, and dry them to obtain amino acid modified microbes. ball.

[0027] It was detected ...

Embodiment 2

[0031] An amino acid modified microsphere is prepared according to the following steps:

[0032] (1) Put 0.07 g of Span-60 and 0.03 g of Tween-20 in a three-necked flask, add 12 ml of n-heptane, set the stirring rate to 325 rpm, and disperse evenly;

[0033] (2) Gradually add 0.07 g of methacrylamide, 0.20 g of amino acid ligand, 0.4 g of N,N’-methylenebisacrylamide, and 1.76 g of formamide and stir until a transparent solution;

[0034] (3) Add 0.07 g of azobisisobutyronitrile to the solution in step (2) to dissolve, then feed nitrogen gas while pumping air with a vacuum pump to remove the air in the system, so that the reaction process is in the state of nitrogen protection;

[0035] (4) Raise the reaction temperature to 70°C, stir for 4 hours, filter to obtain white particles, wash thoroughly with ethanol, and dry in an oven at 70°C to obtain amino acid-modified microspheres.

[0036] After microscopic examination, the particle diameter is about 0.27 millimeters. It is pla...

Embodiment 3

[0039] An amino acid modified microsphere is prepared according to the following steps:

[0040] (1) Put 0.07 g of Span-60 and 0.03 g of Tween-20 in a three-necked flask, add 12 ml of n-heptane, set the stirring rate to 325 rpm, and disperse evenly;

[0041] (2) Gradually add 0.07 g of methacrylamide, 0.10 g of amino acid ligand, 0.4 g of N,N’-methylenebisacrylamide, and 1.76 g of formamide and stir until a transparent solution;

[0042] (3) Add 0.07 g of azobisisobutyronitrile to the solution in step (2) to dissolve, then feed nitrogen gas while pumping air with a vacuum pump to remove the air in the system, so that the reaction process is in the state of nitrogen protection;

[0043] (4) Raise the reaction temperature to 70°C, stir for 4 hours, filter to obtain white particles, wash thoroughly with ethanol, and dry in an oven at 70°C to obtain amino acid-modified microspheres.

[0044] The particle size is about 0.29 millimeters through microscope detection, and it is place...

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Abstract

The invention discloses a preparation method of amino acid modified microspheres and a product thereof. Under nitrogen gas protection, a reaction between monomers containing double bonds and amino acid ligands containing double bonds is initiated by a thermal initiator so as to polymerize the double bonds; according to the present invention, the amino acid ligand is grafted on the surface of the microsphere, such that the material is converted into the heterogeneous catalyst from the homogeneous catalyst, is easy to separate from the reaction system, and does not swell in the organic solvent,such that the industrial application value of the product is improved. The particle size of the amino acid microspheres disclosed by the invention is about 0.25-0.30 mm through detection of a microscope; and the microspheres can be separated only in a filtering manner.

Description

technical field [0001] The invention relates to a method for preparing amino acid modified microspheres and products thereof, belonging to the technical field of organic polymer material preparation. Background technique [0002] The study found that the traditional reaction of introducing a planar chiral structure into a ferrocene structure requires expensive catalysts and harsh reaction conditions, requiring equivalent lithium reagents, chiral bases, etc. The chiral structure is introduced into the ferrocene framework, and the conditions are relatively mild, but because most of them are homogeneous catalysts, it is difficult to recover the catalyst after the reaction. At the same time, the study found that amino acid ligands can be grafted on the surface of polystyrene microspheres, but the microspheres will swell in organic solvents. [0003] Therefore, in order to solve the above-mentioned defects of the catalyst, the amino acid ligand is polymerized by a thermal initia...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F220/58C08F222/38C08J9/28B01J35/08
CPCC08F220/56C08J9/28C08J2333/26B01J35/40B01J35/51C08F220/58C08F222/385
Inventor 何丹农杨玲袁静蔡婷金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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