Functionalized polyethyleneimine-wrapped nano-gold particle composite material and preparation method thereof
A technology of polyethyleneimine and nano-gold particles, which is applied in the direction of radioactive carriers, can solve the problems of large injection, low concentration of nano-contrast agents, and limited imaging effects, etc., and achieves easy operation, good pH response, charge reversal performance, The effect of the simple preparation process
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Embodiment 1
[0080] (1) Dissolve trityl mercaptan (5.0 g, 18.1 mmol) with ethanol-benzene mixed solvent (50 mL) with a volume ratio of 1:1, and add 9.5 mL of NaOH solution (0.9 g, 22.6 mmol), and then add 11-Bromoundecanol (4.5 g, 18 mmol) was dissolved in ethanol-benzene mixed solution (50 mL) at a volume ratio of 1:1. The mixed solution was stirred for 12 h, after which the reaction mixture was added to saturated NaHCO 3 Extracted in the solution, washed twice, separated the organic phase and transferred it to a saturated NaCl solution for extraction, washed twice, and the separated organic phase was washed with NaCl 2 SO 4 The solution obtained after drying was concentrated by a rotary evaporator to obtain a crude product, which was purified by silica gel column chromatography, using hexane-ethyl acetate at a volume ratio of 4:1 as the eluent, and the collected product was concentrated by a rotary evaporator again 1,1,1-Triphenyl-2-thia-13-carbon tridecanol is obtained.
[0081] (2) ...
Embodiment 2
[0094] (1) Dissolve trityl mercaptan (18.1mmol) in an ethanol-benzene mixed solvent with a volume ratio of 1:1, and add NaOH solution (22.6mmol), then add the ethanol-benzene solution dissolved in a volume ratio of 1:1 11-bromoundecanol (18 mmol) in the mixed solution. The mixed solution was stirred for 8 h, after which the reaction mixture was added to saturated NaHCO 3 Extracted in the solution, washed twice, separated the organic phase and transferred it to a saturated NaCl solution for extraction, washed twice, and the separated organic phase was washed with NaCl 2 SO 4 The solution obtained after drying was concentrated by a rotary evaporator to obtain a crude product, which was purified by silica gel column chromatography, using hexane-ethyl acetate at a volume ratio of 4:1 as the eluent, and the collected product was concentrated by a rotary evaporator again 1,1,1-Triphenyl-2-thia-13-carbon tridecanol is obtained.
[0095] (2) Dissolve 1,1,1-triphenyl-2-thia-13-carbo...
Embodiment 3
[0108] The difference between Example 3 and Example 2 is that the chelating agent used is 2,2',2"-(10-(2-(2,5-dioxopyrrolidine-1-oxyl)- 2-Oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-tri)triacetic acid.
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