Preparation method of calcium phosphate microflowers

A micron flower and calcium phosphate technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as difficult large-scale production, high energy consumption, cumbersome synthesis process, etc., and achieve simple operation, short reaction time, shape stabilization effect

Pending Publication Date: 2019-08-20
HAINAN UNIVERSITY
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Problems solved by technology

For the synthesis of calcium phosphate nanoflowers, there are mainly aqueous phase synthesis, high temperature solid phase synthesis and template synthesis, but t

Method used

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  • Preparation method of calcium phosphate microflowers
  • Preparation method of calcium phosphate microflowers
  • Preparation method of calcium phosphate microflowers

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preparation example Construction

[0035] Such as figure 1 Shown, a kind of preparation method of calcium phosphate micron flower, comprises the steps:

[0036] S1: Dissolve calcium lactate in deionized water at a concentration of 0.001-100 mol / L under heating and stirring to obtain solution A. During specific implementation, the calcium lactate salt is selected from calcium lactate anhydrous, calcium lactate trihydrate or calcium lactate pentahydrate;

[0037] S2: under stirring, dissolve creatine phosphate disodium salt in deionized water according to the concentration of 0.001-100mol / L to obtain solution B;

[0038] S3: Wait until the solution A is cooled to room temperature, and mix the solution A with the solution B according to the molar ratio of calcium lactate and creatine phosphate (0.1-5.0):1 to obtain a mixed solution C;

[0039] S4: Slowly add an aqueous sodium hydroxide solution with a concentration of 2M under stirring, and adjust the pH value of the mixed solution to between 7-14;

[0040] S5:...

Embodiment 1

[0045] (1) Weigh 0.262g of calcium lactate pentahydrate, and dissolve calcium lactate in 100mL of deionized water under heating and stirring to obtain a solution A with a concentration of 12mM;

[0046] (2) Under stirring, dissolve 0.317g of creatine phosphate disodium salt in 100mL of deionized water to obtain a solution B with a concentration of 15mM;

[0047] (3) Wait until solution A is cooled to room temperature, and mix solution A and solution B according to the molar ratio of calcium lactate and creatine phosphate as 0.8:1 to obtain mixed solution C;

[0048] (4) Under stirring, slowly add a 2M sodium hydroxide aqueous solution to adjust the pH value of the mixed solution to 10;

[0049] (5) Transfer the mixed solution to a microwave reactor, and place it in the microwave reactor for microwave hydrothermal synthesis. The microwave reaction time is 10min, and the microwave reaction temperature is controlled at 120°C;

[0050] (6) After the reaction, the microwave react...

Embodiment 2

[0053] (1) Weigh 0.546g of calcium lactate pentahydrate, and dissolve calcium lactate in 100mL of deionized water under heating and stirring to obtain a solution A with a concentration of 24mM;

[0054] (2) Under stirring, dissolve 0.317g of creatine phosphate disodium salt in 100mL of deionized water to obtain a solution B with a concentration of 15mM;

[0055] (3) Wait until solution A is cooled to room temperature, and mix solution A and solution B according to the molar ratio of calcium lactate and creatine phosphate as 1.67:1 to obtain mixed solution C;

[0056](4) Under stirring, slowly add a 2M sodium hydroxide aqueous solution to adjust the pH value of the mixed solution to 10;

[0057] (5) Transfer the mixed solution to a microwave reactor, and place it in the microwave reactor for microwave hydrothermal synthesis. The microwave reaction time is 10min, and the microwave reaction temperature is controlled at 120°C;

[0058] (6) After the reaction, the microwave react...

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Abstract

The invention relates to the field of biomaterial preparation, specifically to a preparation method of calcium phosphate microflowers. The preparation method comprises the following steps: S1: mixinga calcium lactate aqueous solution and a phosphocreatine aqueous solution, stirring and adding a sodium hydroxide aqueous solution with the concentration of 2M, adjusting pH value of the solution within a preset range, wherein the molar ratio of calcium lactate to phosphocreatine is (0.1-5.0): 1; S2: carrying out a microwave hydrothermal synthesis reaction on the mixed aqueous solution obtained inthe Step S1; and S3: centrifuging, washing and drying to obtain a solid powder of calcium phosphate microflowers. The method has advantages of simple operation, low energy consumption, environmentally-friendliness and stable product quality, and is beneficial to large-scale production.

Description

technical field [0001] The invention relates to the field of biological material preparation, in particular to a method for preparing calcium phosphate micron flowers. Background technique [0002] Calcium phosphate has good biocompatibility, making calcium phosphate-based biomaterials widely used in biomedical fields, such as tissue engineering, bone repair, and drug delivery. In order to expand the application range of calcium phosphate and improve the performance of calcium phosphate, a variety of calcium phosphate materials with different morphology and microstructure have been developed, including carbonated hydroxyapatite microspheres with mesoporous structure, hydroxyapatite Microtubules, hollow hydroxyapatite nanowires, amorphous calcium phosphate nanospheres with core-shell structure, etc. Studies have shown that calcium phosphate microspheres with a microflower structure have higher specific surface area and larger internal pores, which are conducive to improving ...

Claims

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Application Information

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IPC IPC(8): C01B25/32
CPCC01B25/32C01P2004/61C01P2004/32
Inventor 杨永曹献朔曹献英王凯郭兰周鑫曹阳
Owner HAINAN UNIVERSITY
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