Pharmaceutical composition with anti-asthmatic activity and application thereof

A composition and drug technology, applied in the direction of drug combination, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as easy bleeding, poor wound healing, purple streaks, etc., and achieve enhanced quality effects, good mast cells Stabilizing and anti-inflammatory effects, dose reduction effects

Inactive Publication Date: 2019-08-23
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the course of long-term medication, iatrogenic Cushing's syndrome, appearance and posture, weight gain, lower extremity edema, purple streaks, easy bleeding tendency, poor wound healing, acne, menstrual disorders, and avascular necrosis of the humerus or femoral head are prone to occur. , osteoporosis and fractures (including vertebral compression fractures, long bone pathological fractures), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, etc. serious side effects

Method used

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  • Pharmaceutical composition with anti-asthmatic activity and application thereof
  • Pharmaceutical composition with anti-asthmatic activity and application thereof
  • Pharmaceutical composition with anti-asthmatic activity and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The mouse asthma model established by ovalbumin (OVA) was used to compare the therapeutic effects of dexamethasone and isoimperatorin alone and in combination on allergic asthma.

[0032] Get C57 / BL6 mouse, divide into 7 groups randomly, namely blank control group (PBS), model control group (PBS), isoimperatorin group (10mg / kg), dexamethasone low concentration group (2.5mg / kg). kg), dexamethasone high concentration group (5mg / kg) and combined administration group (2.5mg / kg dexamethasone+10mg / kg isoimperatorin).

[0033] On the 1st, 3rd, 5th and 7th days, the mice in each group were intraperitoneally injected with 0.5 mg / kg OVA to sensitize the mice, and the blank control group was injected with normal saline. On the 21st, 23rd, 25th, 27th and 29th day, the mice were placed in a closed container, and 1% OVA was inhaled to induce asthma attack, once a day, 30 minutes each time. The blank control group inhaled normal saline by nebulization.

[0034] Intragastric administ...

Embodiment 2

[0040] To compare the effects of long-term single administration and combined administration of dexamethasone and isoimperatorin on the femoral head of mice.

[0041]Get C57 / BL6 mouse, be divided into 5 groups at random, i.e. blank control group, isoimperatorin group (10mg / kg), dexamethasone low concentration group (2.5mg / kg), dexamethasone high concentration group ( 5mg / kg) and combined administration group (10mg / kg isoimperatorin+2.5mg / kg dexamethasone).

[0042] Continuous intragastric administration for 30 days.

[0043] After the administration, the femoral heads on both sides of the mice were removed, and the surrounding soft tissues were removed and placed in place for HE staining after decalcification. Observe the changes of bone trabeculae, bone cells, and adipocytes in the medullary cavity.

[0044] from figure 2 In (a), (b), and (c), it can be seen that the cartilage layer of the femoral head in the blank control group is thicker, and the bone trabeculae are fil...

Embodiment 3

[0046] A pharmaceutical composition with anti-asthma activity, comprising dexamethasone and isoimperatorin in a mass ratio of 1:20.

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Abstract

The invention provides a pharmaceutical composition with anti-asthmatic activity and application thereof. The pharmaceutical composition comprises dexamethasone and isoimperatorin in a mass ratio of (1-2.5):(10-20). The pharmaceutical composition is high in anti-allergic asthma activity, and through the combination of the artificially synthesized corticosteroid dexamethasone and the isoimperatorin, the pharmaceutical composition is efficient, low in toxicity and capable of inhibiting mastocyte; combined administration is conducted by using the activated natural product isoimperatorin so that the toxic and side effects of medicines in the composition can be reduced; the pharmaceutical composition has good mastocyte-stabilizing and anti-inflammation effects, finally, the effect of treating allergic asthma is improved, and the pharmaceutical composition can be used in the field of preparation of anti-allergic asthma drugs.

Description

technical field [0001] The invention belongs to the field of anti-allergic asthma drugs, in particular, the invention relates to a pharmaceutical composition with anti-asthma activity and application thereof. Background technique [0002] Allergic asthma is a disease in which the body reacts excessively to antigenic or non-antigenic stimuli, and it has become one of the diseases that seriously threaten human health. At present, the commonly used drugs for the clinical treatment of allergic asthma are hormones, β2-receptor agonists, leukotriene regulators, theophylline, anticholinergic drugs, SIT and other asthma drugs (antihistamine, anti-allergic drugs, etc.), etc. Most of the above drugs are used to relieve clinical symptoms, but cannot fundamentally solve the problem of asthma, and these drugs have a variety of adverse reactions, such as osteoporosis, hypokalemia, arrhythmia and other drowsiness. All of the above drugs have developed drug resistance, reaching the point w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/352A61P37/08A61P11/06
CPCA61K31/352A61K31/573A61P11/06A61P37/08A61K2300/00
Inventor 贺浪冲王楠张涛王珏张永竟曾莹楠
Owner XI AN JIAOTONG UNIV
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