Mussel bionic binder-calcium phosphate high-strength bone repair material, high-strength composite CaP scaffold and preparation method thereof

Abstract

The invention belongs to the technical field of biological materials, and specifically relates to a mussel bionic binder-calcium phosphate high-strength bone repair material, a high-strength compositeCaP scaffold and a preparation method thereof. In view of the problems of insufficient strength, especially toughness, and insufficient printability and formability of bone repair materials in the prior art, the invention discloses the mussel bionic binder-calcium phosphate high-strength bone repair material and the preparation method thereof. The technical scheme is as follows: the mussel bionicbinder-calcium phosphate high-strength bone repair material is prepared from the following materials in parts by weight: 5-35 parts of a bionic binder, 65-95 parts of calcium phosphate salt and 95-105 parts of deionized water, wherein the bionic binder is prepared by dissolving 1-3 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the calcium phosphate salt is prepared by mixing alpha-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate. The mussel bionic binder-calcium phosphate high-strength bone repair material is applicable to the repair of bone injury.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a mussel bionic adhesive-calcium phosphate high-strength bone repair material, a high-strength composite CaP support and a preparation method thereof. Background technique [0002] In the treatment of bone injuries, artificially synthesized bone repair materials are usually required to reconstruct the normal structure and function of bone tissue. Synthetic bone repair materials need to have excellent mechanical properties (high compressive strength, toughness, and proper elasticity) to complete functions such as supporting body weight, maintaining posture, and protecting internal organs. Low-crystalline nano-calcium phosphate (CaP) porous scaffolds imitating bone tissue have excellent biocompatibility and osteoconductivity, and have been widely used in clinical bone repair. However, the current clinically used CaP scaffolds still face the following probl...

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Problems solved by technology

[0006] Aiming at the problems of insufficient mechanical properties and insufficient printability and formability of bone repair materials in the prior art, the present invention provides a mussel biomimetic adhesive-calcium phosphate high-strength bone repair material, a high-strength composite CaP scaffold and a preparation method thereof. The purpose is to: improve the mechanical properties of the existing CaP bone repair materials, improve the printability of the bone repair materials in the prior art, and improve the coagulation and formability of the bone repair material slurry

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