Mussel bionic binder-calcium phosphate high-strength bone repair material, high-strength composite CaP scaffold and preparation method thereof

A biomimetic adhesive and high-strength technology, applied in the field of high-strength composite CaP scaffold and its preparation, mussel biomimetic adhesive-calcium phosphate high-strength bone repair material, can solve the problem of insufficient printability and formability, mechanical properties Insufficient and other problems, to achieve the effect of no interaction, simple preparation method and good solubility

Active Publication Date: 2019-08-30
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems of insufficient mechanical properties and insufficient printability and formability of bone repair materials in the prior art, the present invention provides a mussel biomimetic adhesive-calcium phosphate high-strength bone repair material, a high-strength composit

Method used

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  • Mussel bionic binder-calcium phosphate high-strength bone repair material, high-strength composite CaP scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A mussel bionic adhesive-calcium phosphate high-strength bone repair material comprises 15 parts of bionic adhesive, 90 parts of calcium phosphate salt and 100 parts of deionized water in parts by weight.

[0039] Preferably, the biomimetic adhesive is prepared by dissolving 3 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the mixed solvent is anhydrous ethanol and ethylene glycol in a volume ratio of 1 : Prepared by mixing 3.

[0040] Preferably, the calcium phosphate salt is prepared by mixing α-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate in a weight ratio of 1:1:1:1.

[0041] A preparation method of mussel bionic adhesive-calcium phosphate high-strength bone repair material, comprising the following steps:

[0042] (1) Mix the biomimetic adhesive, calcium phosphate salt and deionized water in proportion and stir evenly (the stirring time is 20min, and the rotatin...

Embodiment 2

[0052] A mussel biomimetic adhesive-calcium phosphate high-strength bone repair material is characterized in that: by weight, it includes 35 parts of biomimetic adhesive, 85 parts of calcium phosphate salt and 105 parts of deionized water.

[0053] Preferably, the biomimetic adhesive is prepared by dissolving 3 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the mixed solvent is anhydrous ethanol and ethylene glycol in a volume ratio of 1.1 : 3.2 prepared by mixing.

[0054] Preferably, the calcium phosphate salt is prepared by mixing α-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate in a weight ratio of 1:0.5:0.75:1.

[0055] A preparation method of mussel bionic adhesive-calcium phosphate high-strength bone repair material, comprising the following steps:

[0056] (1) The bionic adhesive, calcium phosphate salt and deionized water are mixed in proportion and stirred evenly (t...

Embodiment 3

[0066] A mussel biomimetic adhesive-calcium phosphate high-strength bone repair material is characterized in that, by weight, it includes 12 parts of biomimetic adhesive, 95 parts of calcium phosphate salt and 100 parts of deionized water.

[0067] Preferably, the biomimetic adhesive is prepared by dissolving 2 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the mixed solvent is anhydrous ethanol and ethylene glycol in a volume ratio of 0.8 : 2.5 mixed preparation.

[0068] Preferably, the calcium phosphate salt is prepared by mixing α-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate in a weight ratio of 1.2:0.75:0.75:1.

[0069] A preparation method of mussel bionic adhesive-calcium phosphate high-strength bone repair material, comprising the following steps:

[0070] (1) The biomimetic adhesive, calcium phosphate salt and deionized water are mixed in proportion and stirred eve...

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Abstract

The invention belongs to the technical field of biological materials, and specifically relates to a mussel bionic binder-calcium phosphate high-strength bone repair material, a high-strength compositeCaP scaffold and a preparation method thereof. In view of the problems of insufficient strength, especially toughness, and insufficient printability and formability of bone repair materials in the prior art, the invention discloses the mussel bionic binder-calcium phosphate high-strength bone repair material and the preparation method thereof. The technical scheme is as follows: the mussel bionicbinder-calcium phosphate high-strength bone repair material is prepared from the following materials in parts by weight: 5-35 parts of a bionic binder, 65-95 parts of calcium phosphate salt and 95-105 parts of deionized water, wherein the bionic binder is prepared by dissolving 1-3 parts by weight of 3.4-dihydroxyphenylmethacrylamide in 10 parts by weight of a mixed solvent, and the calcium phosphate salt is prepared by mixing alpha-tricalcium phosphate, hydroxyapatite, calcium hydrogen phosphate dihydrate and calcium carbonate. The mussel bionic binder-calcium phosphate high-strength bone repair material is applicable to the repair of bone injury.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a mussel bionic adhesive-calcium phosphate high-strength bone repair material, a high-strength composite CaP support and a preparation method thereof. Background technique [0002] In the treatment of bone injuries, artificially synthesized bone repair materials are usually required to reconstruct the normal structure and function of bone tissue. Synthetic bone repair materials need to have excellent mechanical properties (high compressive strength, toughness, and proper elasticity) to complete functions such as supporting body weight, maintaining posture, and protecting internal organs. Low-crystalline nano-calcium phosphate (CaP) porous scaffolds imitating bone tissue have excellent biocompatibility and osteoconductivity, and have been widely used in clinical bone repair. However, the current clinically used CaP scaffolds still face the following probl...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/50
CPCA61L27/12A61L27/50A61L2400/06A61L2430/02
Inventor 熊雄屈树新周思捷张纯姑单连海
Owner SOUTHWEST JIAOTONG UNIV
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