A Magnetic Resonance Method for Measuring Clearance Efficiency of the Human Brain's Lymphoid Pathways

A magnetic resonance and human brain technology, applied in the field of medical imaging, can solve the problems of invasive injury, inability to apply clinical detection, etc., and achieve the effect of easy operation

Active Publication Date: 2020-05-19
兰月
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The existing method needs to inject the tracer into the cerebellum magna, which is invasive and harmful, and can only be realized on experimental animals, and cannot be applied to clinical testing

Method used

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  • A Magnetic Resonance Method for Measuring Clearance Efficiency of the Human Brain's Lymphoid Pathways
  • A Magnetic Resonance Method for Measuring Clearance Efficiency of the Human Brain's Lymphoid Pathways
  • A Magnetic Resonance Method for Measuring Clearance Efficiency of the Human Brain's Lymphoid Pathways

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Experimental program
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Embodiment 1

[0033] Concrete implementation steps of the present invention are:

[0034] (1) Using the Siemens 3T magnetic resonance imaging system, subjects were subjected to routine clinical cranial magnetic resonance imaging examinations, and the scanning sequence included: T1-weighted images and diffusion tensor imaging (DTI). The scanning parameters of T1 weighted images are: 176 axial slices, slice thickness / gap=1.0 / 0.5mm, TR=2530ms, TE=3.39ms, inversion time (TI)=900ms, flip angle=7°, FOV=256×256mm 2 . DTI scan parameters are: 45axial slices, slice thickness / gap=3.0 / 0mm, TR=8300ms, TE=86ms, 64diffusion directions withb=1000s / mm 2 , acquisition matrix=128×128, FOV=230×230mm 2 .

[0035] (2) Export the original DICOM format data, use dcm2nii for format conversion, and convert DICOM format to NIfTI format.

[0036] (3) Use the dMRI data processing software PANDA for data preprocessing, including: head motion eddy current correction, gradient direction correction, brain mask acquisi...

Embodiment 2

[0042] Description of the specific application effect of the present invention:

[0043] (1) Clinical data: Select 11 patients with vascular dementia, aged 50-80 years old, MRI examination confirmed cerebrovascular disease, at least 2 cognitive domains were damaged, and their cognitive impairment affected the ability of daily life; 6 cases were selected Patients with vascular mild cognitive impairment, aged 50-80 years, with cerebrovascular disease confirmed by MRI examination, at least one cognitive domain is impaired, and instrumental daily living ability can be normal or slightly impaired; 8 normal cases were selected The subjects, aged 50-80 years, had no evidence of cerebrovascular disease, no decline in cognitive function, and normal activities of daily living after MRI examination.

[0044] (2) Methods: The subjects underwent cognitive function tests and head magnetic resonance imaging examinations. The evaluation scales used in cognitive function tests are the Mini-Me...

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Abstract

The invention provides a method for measuring clearance efficiency of human brain lymphatic pathway by magnetic resonance. The method contains a following formula: CEPS index equals mean(Dx,p,Dx,a) / mean(Dy,p,Dz,a). The method realizes conventional clinical magnetic resonance imaging, uses a technology and algorithm for imaging data processing and calculation, and realizes quantitative monitoring of the clearance efficiency of the human brain lymphatic pathway without the need to inject a tracer from the cisterna magna, therefore, the method has the advantages of non-invasion, non-damage, convenience, and easy operation, and can be applied to clinical testing.

Description

technical field [0001] The invention belongs to the field of medical imaging, and in particular relates to a method for measuring the clearance efficiency of human brain lymphoid pathway by magnetic resonance. Background technique [0002] The cerebral glymphatic system is a system that removes metabolic waste in the brain through the flow of cerebrospinal fluid in the cerebral glymphatic pathway. Lymphatic pathways in the brain include paraarterial space, interstitial fluid, and paravenous space, also known as paravascular space-interstitial fluid pathway. The existing methods for quantitatively measuring the glymphoid pathways in the brain are: injecting tracers into the cerebellum magna to image the cerebrospinal fluid, using two-photon confocal microscopy in vivo imaging or dynamic contrast-enhanced magnetic resonance imaging, and observing the tracer in the brain lymphoid pathways. Metabolism in pathways. [0003] The existing method needs to inject the tracer into th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/055
CPCA61B5/055
Inventor 兰月徐光青黄易清裴中
Owner 兰月
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