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An antibacterial bone-containing rubidium-titanium-tantalum composite material and its preparation method and application

A composite material and osteogenesis-promoting technology, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve problems such as poor biological activity, poor antibacterial property, and surgical failure, and achieve good antibacterial and osteogenesis-promoting performance, wide application prospects, and solve biological problems. The effect of poor compatibility

Active Publication Date: 2021-09-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the problems in the prior art that the medical titanium-tantalum composite material has poor antibacterial properties and poor biological activity, and it is easy to cause operation failure in actual clinical application, the purpose of the present invention is to provide an antibacterial material with excellent mechanical properties, biological activity and antibacterial properties. Promoting bone-containing rubidium-titanium-tantalum composite material and its preparation method and application

Method used

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  • An antibacterial bone-containing rubidium-titanium-tantalum composite material and its preparation method and application
  • An antibacterial bone-containing rubidium-titanium-tantalum composite material and its preparation method and application
  • An antibacterial bone-containing rubidium-titanium-tantalum composite material and its preparation method and application

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Embodiment 1

[0047] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then place the titanium-tantalum alloy powder in a cold isostatic press for compression molding, and the compression pressure is 200MPa , the pressing time is 4min, and then the pressed green body is sintered in vacuum sintering, and the vacuum degree is controlled to be 10 -4 Pa, the vacuum sintering temperature is 1200°C, the sintering time is 2h, and the heating rate is 45°C / min.

[0048] The titanium-tantalum composite material is subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution is composed of hydrochloric acid (mass fraction: 38% to write the specific value), sulfuric acid (mass fraction: 96% to write the specific value ) mixed with water in a volume ratio of 1:1:1.17. Put the acid-treated titanium-tantalum composite material in 4M ...

Embodiment 2

[0077] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then place the titanium-tantalum alloy powder in a cold isostatic press for compression molding, and the compression pressure is 180MPa , the pressing time is 3min, and then the pressed green body is sintered in vacuum sintering, and the vacuum degree is controlled to be 10 -4 Pa, the vacuum sintering temperature is 1300°C, the sintering time is 2h, and the heating rate is 50°C / min.

[0078] The titanium-tantalum composite material was sandblasted, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution was composed of hydrochloric acid (mass fraction: 37%), sulfuric acid (mass fraction: 95%) and water in a volume ratio of 1:1:1.4 mixed to obtain. Put the acid-treated titanium-tantalum composite material in 5M sodium hydroxide solution, and perform alkali heat treatment at 60°C fo...

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Abstract

The invention discloses an antibacterial and bone-containing rubidium-titanium-tantalum composite material and a preparation method thereof. In the method, the titanium-tantalum composite material synthesized by cold isostatic pressing and vacuum sintering is subjected to sandblasting, acid treatment and alkali heat treatment to make titanium-tantalum composite The surface of the material is modified, and the surface of the surface-modified titanium-tantalum composite material is doped with rubidium salt through ion exchange, and finally the antibacterial bone-promoting rubidium-titanium-tantalum composite material is prepared by high-temperature calcination. The material of the invention has good antibacterial properties and biocompatibility, does not have cytotoxicity, promotes cell proliferation, and has a good effect of inducing osteogenic differentiation of pre-osteoblasts. The material can effectively solve the problems of easy infection of bacteria in clinical application of bone repair materials and poor compatibility between implant materials and human body, and has broad application prospects in clinical bone repair.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an antibacterial bone-promoting composite material containing rubidium, titanium and tantalum, a preparation method and application thereof. Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium-tantalum composite materials are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium-tantalum composite materials. material as a bone replacement material. However, since the titanium-tantalum composite material is a biologically inert material, the combinatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/54A61L27/56C22C1/04C22C27/02
CPCA61L27/427A61L27/54A61L27/56A61L2300/102A61L2300/404A61L2430/02C22C1/045C22C27/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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