Method for extracting cannabidiol by subcritical fluid technology and purification method thereof

Abstract

The invention relates to a method for extracting cannabidiol by a subcritical fluid technology and a purification method thereof. The extraction method comprises the following steps: grinding dried industrial hemp leaves, filling the powder into silk bags, adding the silk bags into an extraction tank, conducting a preheating experiment, and starting a vacuum pump; opening a solvent injection valveof the extraction tank, injecting an organic solvent until all the silk bags are immersed in the solvent, turning on a hot water circulation system pump, and performing extraction so as to obtain anoil-soluble mixture; pressing the oil-soluble mixture into a separating tank from the extraction tank, and performing heating pressurization and desolventizing treatment on the oil-soluble mixture soas to obtain a liquid organic solvent and a liquid mixture; enabling the liquid organic solvent to enter a storage tank for recycling, and collecting the crude cannabidiol extract; dissolving the crude cannabidiol extract into ethanol, performing filtering after full dissolving, and performing elution by a reverse chromatography column; and concentrating and crystallizing the target eluent so as to obtain the cannabidiol extract. The method disclosed by the invention has the advantages of low energy consumption and capacity of realizing cyclic utilization of the organic solvent, and the extraction and separation process is environment-friendly and low in toxicity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction technology, and in particular relates to a subcritical fluid technology for extracting cannabidiol and a purification method thereof. Background technique [0002] Marijuana (Cannabis sativa L.) is an ancient plant with medicinal development value. Cannabidiol (CBD) is a monomer extracted from marijuana. It is the first cannabinoid drug approved by FDA. , CBD has pharmacological effects such as anti-spasm, anti-anxiety, anti-inflammation, anti-oxidation, anti-rheumatic, anti-tumor; the application of CBD in the medical field is mainly based on its protective effect on the nervous system; The dual inhibition of synthase exerts analgesic and anti-inflammatory effects, and the effect is stronger than that of aspirin, which is well-known and widely used; GABA neurotransmitters in the human brain have a sedative effect, inhibiting the excitability of the brain center, an...

AI Technical Summary

Problems solved by technology

[0004] 1) Solvent extraction is the most used in the existing cannabidiol extraction process, one is to add a large amount of organic solvents with high solubility of cannabidiol, such as n-hexane, petroleum ether, dichloromethane, chloroform and methanol, etc., although The extraction rate of cannabidiol is improved, but the use of organic solvents will harm the environment, and the solvent residues in the final product cannot be removed, which also affects product safety; the other uses ethanol as the extractant, although it reduces the organic solvent toxicity, but there is the problem of low extraction rate caused by low solubility of cannabidiol, and the loss of solvent recovery is large and the cost is high

[0005] 2) Supercritical CO2 fluid extraction technology has been used in the extraction process of cannabidiol in recent years. Although supercritical extraction has the advantages of strong extraction capacity, high extraction rate, strong selectivity, and good product quality, it also has high cost and energy consumption. High, difficult to achieve industrial scale-up production and other shortcomings