Application of Fructus Amomi Rotundus essential oil

A technology of white cardamom and essential oil, applied in the field of biomedicine, to achieve the effect of improving biological activity, long half-life, and small side effects

Inactive Publication Date: 2019-09-20
东莞怀朴植物精油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of Fructus Amomi Rotundus essential oil
  • Application of Fructus Amomi Rotundus essential oil
  • Application of Fructus Amomi Rotundus essential oil

Examples

Experimental program
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Effect test

preparation example Construction

[0041] The method for preparing white cardamom essential oil of the present invention includes steam distillation extraction and carbon dioxide supercritical extraction.

[0042] The essential oil of white cardamom of the present invention is detected by Gas Chromatography-Mass Spectrometer (GC-MS), and its component ratio is eucalyptol (eucalyptol) in terms of mass percentage (> 60%), β-pinene (β-pinene) (> 7%), α-terpineol (> 5%), α-pinene (α-pinene) (> 2%).

Embodiment 1

[0044] Take 100Kg of fresh or dried fruits or leaves of white cardamom (Amomurn kravanh Pierre ex Gagnep.), put them in a pile for 2 days, crush them to 50 mesh coarse particles, and soak the coarse particles in 8 mass times the pH value of 5.0 hydrochloric acid aqueous solution, Extract overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture and enzymatically hydrolyzed at 37°C for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction instrument, reflux and extract at 110°C for 7 hours, collect the distillate, cool it to room temperature and place it in an oil-water separator for separation. The oil layer is dried and separated with anhydrous sodium sulfate to obtain white cardamom essential oil.

Embodiment 2

[0046] Take 100Kg of fresh or dried fruits or leaves of Java white cardamom (Amomum compactum Soland ex Maton), put them in a pile for 2 days, crush them to 50 mesh coarse particles, and soak the coarse particles in 8 mass times the pH value of 5.0 hydrochloric acid aqueous solution, Extract overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture and enzymatically hydrolyzed at 37°C for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction instrument, reflux and extract at 110°C for 7 hours, collect the distillate, cool it to room temperature and place it in an oil-water separator for separation. The oil layer is dried and separated with anhydrous sodium sulfate to obtain white cardamom essential oil.

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Abstract

The invention discloses application of Fructus Amomi Rotundus essential oil. The Fructus Amomi Rotundus essential oil can be used for preparing drugs for treating or preventing brain functions and disorders and health products for improving brain functions and disorders. The invention discloses new application of Fructus Amomi Rotundus essential oil in medicines or health products showing activity in brain functions and disorder diseases of experimental animals for the first time; for the first time, it discovers that the Fructus Amomi Rotundus essential oil or a composition containing the Fructus Amomi Rotundus essential oil or any combination of the Fructus Amomi Rotundus essential oil can be used for improving brain functions such as senile dementia, depression and anxiety and symptoms of animals suffering from the brain functions and the like in animal in-vivo models. Compared with an existing medicine for treating brain functions and disorders, the Fructus Amomi Rotundus essential oil or any composition thereof has a mechanism of inhibiting cholinesterase, regulating neurotransmitters and other multi-molecular synergistic effects on multiple targets, has good pharmacokinetic parameters and is easy to permeate a blood-brain barrier, and therefore has the characteristics of toxicological safety, stable metabolism, longer half-life and smaller side effects.

Description

Technical field [0001] The present invention relates to the technical field of biomedicine, in particular to the application of white cardamom essential oil in the preparation of medicines for treating or preventing brain function and disorders, and health products for improving brain function and disorders. Background technique [0002] White cardamom (Amomurn kravanh Pierre ex Gagnep.), a plant of the ginger family, is native to Cambodia and Vietnam. my country is currently mainly cultivated in Yunnan, Guangxi, Guangdong and other places. White cardamom is a traditional medicinal and edible plant, and its dried and mature fruit is an important Chinese medicinal material, which was first published in Kaibao Materia Medica. White cardamom has the effects of dispelling dampness and promoting qi, warming and stopping vomiting, appetizing and eliminating food. It is used for the treatment of damp turbidity, ignorance of diet, early onset of wet temperature, chest tightness but no h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P25/00A61P25/22A61P25/24A61P25/20A61P25/08A61P25/18A61P9/10A61P25/14A61P25/28A61P25/16A61K8/92A61Q19/00C11B9/02A61K125/00
CPCA61K8/922A61K36/9064A61K2236/19A61K2236/331A61K2236/333A61K2236/37A61K2800/782A61P9/10A61P25/00A61P25/08A61P25/14A61P25/16A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61Q19/00C11B9/02C11B9/022C11B9/025C11B9/027
Inventor 许敏韩佳欣陈淑霞曹海龙罗道玉郑三会李云辉顾培爽宋晖
Owner 东莞怀朴植物精油有限公司
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