Preparation method and application of epsilon-polylysine-containing antimicrobial composition
A polylysine, antimicrobial technology, applied in the field of antisepsis and antibacterial, can solve the problems of low usage, poor inhibitory effect, etc., and achieve the effect of low usage, small usage, and excellent inhibitory effect
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[0029] Example 1
[0030] Table 1 The content of each component of the antimicrobial composition (wt%)
[0031]
[0032]
[0033] Preparation method: In a 100mL three-necked flask with stirring and thermometer, add ε-PL and the components other than water in the solvent according to the content of each component in Table 1 and stir and heat to 35~40℃, then add water to maintain the corresponding temperature , Stir and add the remaining antimicrobial ingredients, continue to stir until completely dissolved, and then cool to below 35°C to obtain a stable and transparent antimicrobial composition solution formula.
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[0034] Example 2
[0035] The cold resistance, heat resistance, and light stability of some formulas in Example 1 were investigated, and compared with the products described in the comparative document (publication number CN104958248A, a biological antibacterial composition and its application in cosmetics), the results are shown in figure 1 , figure 2 ,Table 2.
[0036] Table 2 Part of the formulation stability
[0037]
[0038] figure 1 , figure 2 Table 2 shows that the color of the composition formula does not change under light and high temperature conditions, and the target active content remains unchanged, while the color of the comparative product changes significantly under light and high temperature conditions, reflecting the ε-PL combination contained in this description Good stability of the material.
[0039] Compare product formula combination:
[0040] ε-PL 0.5%; nisin 0.1%; natamycin 0.4%; glycerol 5%; 1,3-butanediol 3%; caprylyl glycol 1%.
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[0041] Example 3
[0042] Antibacterial (antibacterial) test-determination of minimum inhibitory concentration (MIC value).
[0043] The minimum inhibitory concentration (MIC value) of some antimicrobial compositions and ε-PL in Table 1 was determined by the suspension method, and the results are shown in Table 3.
[0044] Table 3 Partial composition minimum inhibitory concentration (MIC value)
[0045]
[0046]
[0047] Table 3 shows the minimum inhibitory concentration of ε-PL single product and part of the composition formula. It can be seen that the inhibitory effect of ε-PL on fungi is much different than that on bacteria, and the composition formula contains 10%-20% ε-PL On the basis of compounding other kinds of antimicrobial agents, the MIC value converted to pure product is still comparable to the single product. Taking formula 5# as an example, the MIC for Staphylococcus aureus is 500ppm, where ε-PL The content is 20%, and the MIC value converted into pure product is 100ppm...
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