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Preparation method and application of epsilon-polylysine-containing antimicrobial composition

A polylysine, antimicrobial technology, applied in the field of antisepsis and antibacterial, can solve the problems of low usage, poor inhibitory effect, etc., and achieve the effect of low usage, small usage, and excellent inhibitory effect

Active Publication Date: 2019-10-01
北京美科兴业生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a composition containing ε-PL, an antimicrobial agent, a solvent and a synergist. In the composition, ε-PL is compounded with various components, which improves the disadvantage of its own poor inhibitory effect on fungi. The antibacterial effect of ε-PL is enhanced, the antibacterial spectrum is expanded, and it can be applied in various personal care products, daily chemical products and household products. The composition has excellent inhibitory effect on common molds and yeasts , wide antibacterial spectrum, stable effect, low dosage

Method used

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  • Preparation method and application of epsilon-polylysine-containing antimicrobial composition
  • Preparation method and application of epsilon-polylysine-containing antimicrobial composition
  • Preparation method and application of epsilon-polylysine-containing antimicrobial composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Each component content (weight %) of antimicrobial composition of table 1

[0031]

[0032]

[0033] Preparation method: In a 100mL three-neck bottle with stirring and thermometer, according to the content of each component in Table 1, add ε-PL and the ingredients in the solvent except water, stir and heat to 35-40°C, then add water, and maintain the corresponding temperature , stir and add the remaining antimicrobial ingredients, continue to stir until completely dissolved and then cool down to below 35°C to obtain a stable and transparent antimicrobial composition solution formula.

Embodiment 2

[0035] Investigate the cold resistance of part of the formula in Example 1, heat resistance, light stability, and compare with the product described in the reference document (publication number CN104958248A, a kind of biological antibacterial composition and its application in cosmetics), the results are shown in figure 1 , figure 2 ,Table 2.

[0036] Formulation stability of table 2 part

[0037]

[0038] figure 1 , figure 2 , Table 2 shows that the color of the composition formula does not change under light and high temperature conditions, and the content of the target active substance remains unchanged, while the color of the comparison product changes greatly under light and high temperature conditions, reflecting the combination of ε-PL in this description good stability of the material.

[0039] Compare Product Formula Combinations:

[0040] ε-PL 0.5%; nisin 0.1%; natamycin 0.4%; glycerol 5%; 1,3-butanediol 3%; caprylyl glycol 1%.

Embodiment 3

[0042] Anti-bacterial (inhibitory) test - minimum inhibitory concentration (MIC value) determination.

[0043] The minimum inhibitory concentration (MIC value) of some antimicrobial compositions and ε-PL in Table 1 was determined by the suspension method, and the results are shown in Table 3.

[0044] The minimum inhibitory concentration (MIC value) of some compositions in table 3

[0045]

[0046]

[0047] Table 3 shows the minimum inhibitory concentration of ε-PL single product and some composition formulations. It can be seen that the inhibitory effect of ε-PL on fungi is much different than that on bacteria, and the composition formulation contains ε-PL 10%-20% On the basis of compounding other varieties of antimicrobial agents, the MIC value converted to the pure product is still comparable to that of the single product. Taking formula 5# as an example, the MIC against Staphylococcus aureus is 500ppm, of which ε-PL The content is 20%, and the MIC value converted into...

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Abstract

The invention discloses a preparation method and application of an epsilon-polylysine-containing antimicrobial composition. The epsilon-polylysine-containing antimicrobial composition comprises the following components of 1 to 20% of epsilon-polylysine, 5 to 35% of other antimicrobial agent, and 60 to 90% of solvent and synergistic additive, wherein the antimicrobial agent is a mixture of one or two of caprylhydroximic acid, levulinic acid, sodium levulinic acid, p-hydroxyacetophenone, ethyl lauroyl arginate, tropolone and octenidine; the solvent and synergistic additive are mixture of water and one or at least two of 1,2-propanediol, methylpropanediol, 1,3-propanediol, 1,3-butanediol, 1,2-hexanediol, 1,2-pentanediol, 1,2-octanediol, 1,2-decanediol, polyethylene glycol, ethylhexylglycerinand propanediol carbonate. The epsilon-polylysine-containing antimicrobial composition can be dissolved into water, be convenient in adding and use, and can be widely applied to the fields of cosmetics, wet tissues, masks, washing and the like.

Description

[0001] The previous patent application of this application is the application date of 2019.04.29; the application number is 201910355595.5; the invention application patent with the title of "A preparation method and application of an antimicrobial composition containing ε-polylysine". technical field [0002] The invention relates to an antimicrobial composition containing ε-polylysine, which is mainly used for antisepsis and antibacterial of personal care products such as cosmetics, wet wipes and washing products and household products. Background technique [0003] ε-polylysine (hereinafter referred to as ε-PL) is derived from the fermentation product of Streptomyces albicans and is a natural microbial preservative. It was approved by the US FDA as a safe food preservative in October 2003 and is widely used in food preservation . ε-PL has a broad antibacterial spectrum, and has inhibitory effects on Gram-positive and negative bacteria, molds, and yeasts, but the inhibitor...

Claims

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Application Information

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IPC IPC(8): A01N43/40A01N37/46A01N37/42A01N37/28A01N47/44A01N35/06A01N35/04A01P1/00A01P3/00A61K8/88A61K8/49A61K8/44A61K8/42A61K8/35A61K8/34A61Q19/00
CPCA01N35/04A01N35/06A01N37/28A01N37/42A01N37/46A01N43/40A01N47/44A61K8/345A61K8/35A61K8/42A61K8/44A61K8/4926A61K8/88A61K2800/524A61Q19/00
Inventor 张慧明冯士清吕萌蒙雪艳于跃
Owner 北京美科兴业生物科技有限公司
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