Injectable bioactive glass containing decalcified bone matrix DBM and preparation method and application thereof

A technology of bioactive glass and decalcified bone matrix, which is applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve problems such as limited supply, need for secondary surgery, immune rejection, etc., to achieve good osteogenic performance and meet Clinical needs, the effect of improving degradation performance
CN110302431AInactive Publication Date: 2019-10-08湖北联结生物材料有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖北联结生物材料有限公司
Publication Date
2019-10-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of bone damage repair biomedical materials, and concretely relates to a preparation method of an injectable bioactive glass containing a decalcified bone matrix DBMand an application thereof. The injectable bioactive glass is composed of a solid phase and a liquid phase, wherein the solid phase is formed by mixing bioactive glass powder and DBM in proportion, and the mass ratio of the bioactive glass powder to the DBM is 3:1; the liquid phase is a carboxymethylcellulose sodium solution, and the concentration is 5-20% by weight; the mass ratio of the solid phase to the liquid phase is 2:1 to 1:2; and the solid phase and the liquid phase are mixed at a solid-liquid ratio and then transferred to a syringe. The injectable bioactive glass containing decalcified bone matrix DBM provided by the invention has good injection type, anti-gelation, osteoconductivity, osteoinductivity, cell activity and good biodegradability, and is suitable for bone damage repair.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials for bone damage repair, and in particular relates to an injectable bioactive glass containing decalcified bone matrix DBM, a preparation method and application thereof. Background technique

[0002] Clinically, the number of patients with bone defects due to aging, tumors, trauma, osteomyelitis, and bone diseases is increasing year by year, and the demand for bone defect repair materials is increasing. Traditional bone repair methods mainly include autologous bone and allogeneic bone transplantation, but there are problems such as immune rejection, limited supply sources, and the need for secondary surgery. With the development of biomaterials, artificial repair materials have attracted much attention. Bioactive glass has a variety of applications. Compared with bulk repair materials, bioactive glass (Bioglass, BG) has good fluidity, biocompatibility, bioactivity and processability. Bioactive...

Claims

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