Injectable bioactive glass containing decalcified bone matrix DBM and preparation method and application thereof

A technology of bioactive glass and decalcified bone matrix, which is applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve problems such as limited supply, need for secondary surgery, immune rejection, etc., to achieve good osteogenic performance and meet Clinical needs, the effect of improving degradation performance

Inactive Publication Date: 2019-10-08
湖北联结生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional bone repair methods mainly include autologous bone and allogeneic bone transplantation, but there are problems such as immune rejection, limited supply sources, and the need for secondary surgery

Method used

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  • Injectable bioactive glass containing decalcified bone matrix DBM and preparation method and application thereof
  • Injectable bioactive glass containing decalcified bone matrix DBM and preparation method and application thereof
  • Injectable bioactive glass containing decalcified bone matrix DBM and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An injectable bioactive glass containing demineralized bone matrix (DBM), prepared by the following method:

[0027] (1) Weigh 8 g of sodium carboxymethyl cellulose with a viscosity coefficient of 12000 mPa.s, add 100 ml of deionized water, dissolve, obtain a liquid phase, and store at room temperature for subsequent use;

[0028] (2) Mix 45S5 bioactive glass with a particle size of 10 μm and flake DBM with a size of 800 μm in a small mortar at a mass ratio of 2:1, and then accurately weigh the liquid phase at a solid-to-liquid ratio of 2:1, The liquid phase is added into the solid phase powder, and the injectable bioactive glass containing decalcified bone matrix (DBM) is obtained after being stirred rapidly and uniformly.

Embodiment 2

[0030] An injectable bioactive glass containing demineralized bone matrix (DBM), prepared by the following method:

[0031] (1) Weighing 10 g of sodium carboxymethyl cellulose with a viscosity coefficient of 8000 mPa.s, adding it to 100 ml of deionized water, dissolving to obtain a liquid phase, and storing it at room temperature for subsequent use;

[0032] (2) Mix 45S5 bioactive glass with a particle size of 4 μm and flake DBM with a size of 800 μm in a small mortar at a mass ratio of 2:1, and then accurately weigh the liquid phase at a solid-to-liquid ratio of 2:1, The liquid phase is added into the solid phase powder, and the injectable bioactive glass containing decalcified bone matrix (DBM) is obtained after being stirred rapidly and uniformly.

Embodiment 3

[0034] An injectable bioactive glass containing demineralized bone matrix (DBM), prepared by the following method:

[0035] (1) Weighing 15 g of sodium carboxymethyl cellulose with a viscosity coefficient of 10000 mPa.s, adding it to 100 ml of deionized water, dissolving to obtain a liquid phase, and storing it at room temperature for subsequent use;

[0036] (2) Mix 45S5 bioactive glass with a particle size of 40 μm and flake DBM with a size of 800 μm in a small mortar at a mass ratio of 2:1, and then accurately weigh the liquid phase at a solid-to-liquid ratio of 2:1, The liquid phase is added into the solid phase powder, and the injectable bioactive glass containing decalcified bone matrix (DBM) is obtained after being stirred rapidly and uniformly.

[0037] The sample of the injectable bioactive glass containing demineralized bone matrix (DBM) prepared by the present invention is carried out injection performance and anti-collapse performance test (see figure 1 ), the res...

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Abstract

The invention belongs to the field of bone damage repair biomedical materials, and concretely relates to a preparation method of an injectable bioactive glass containing a decalcified bone matrix DBMand an application thereof. The injectable bioactive glass is composed of a solid phase and a liquid phase, wherein the solid phase is formed by mixing bioactive glass powder and DBM in proportion, and the mass ratio of the bioactive glass powder to the DBM is 3:1; the liquid phase is a carboxymethylcellulose sodium solution, and the concentration is 5-20% by weight; the mass ratio of the solid phase to the liquid phase is 2:1 to 1:2; and the solid phase and the liquid phase are mixed at a solid-liquid ratio and then transferred to a syringe. The injectable bioactive glass containing decalcified bone matrix DBM provided by the invention has good injection type, anti-gelation, osteoconductivity, osteoinductivity, cell activity and good biodegradability, and is suitable for bone damage repair.

Description

technical field [0001] The invention belongs to the field of biomedical materials for bone damage repair, and in particular relates to an injectable bioactive glass containing decalcified bone matrix DBM, a preparation method and application thereof. Background technique [0002] Clinically, the number of patients with bone defects due to aging, tumors, trauma, osteomyelitis, and bone diseases is increasing year by year, and the demand for bone defect repair materials is increasing. Traditional bone repair methods mainly include autologous bone and allogeneic bone transplantation, but there are problems such as immune rejection, limited supply sources, and the need for secondary surgery. With the development of biomaterials, artificial repair materials have attracted much attention. Bioactive glass has a variety of applications. Compared with bulk repair materials, bioactive glass (Bioglass, BG) has good fluidity, biocompatibility, bioactivity and processability. Bioactive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/50A61L27/54A61L27/10A61L27/20
CPCA61L27/10A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/252A61L2300/414A61L2400/06A61L2430/02C08L1/286
Inventor 张旗代春初司旭祝超胡丽张铁叶莹
Owner 湖北联结生物材料有限公司
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