Use of pefloxacin in preparation of drugs for treatment and prevention of hyperlipidemia or atherosclerosis

A technology for atherosclerosis and pefloxacin, which is applied in the field of preparation of drugs for treating and preventing hyperlipidemia or atherosclerosis, and pefloxacin, can solve the problems of poor clostridium effect and the like, and achieve safety High, strong pharmacological effects, wide-ranging effects

Inactive Publication Date: 2019-10-15
CHENZHOU NO 1 PEOPLES HOSPITAL
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has a strong antibacterial effect on Staphylococcus aureus, and has a very strong antibacterial effect on a variety of Gram-negative bacteria, ampicillin-resistant, and TMP cephalospor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of pefloxacin in preparation of drugs for treatment and prevention of hyperlipidemia or atherosclerosis
  • Use of pefloxacin in preparation of drugs for treatment and prevention of hyperlipidemia or atherosclerosis
  • Use of pefloxacin in preparation of drugs for treatment and prevention of hyperlipidemia or atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Rats fed with high-fat feed form a lipid metabolism disorder model

[0022] Forty male SD rats, weighing 160-180g, were fed adaptively for 5 days. The animals were stratified by body weight and then randomly divided into 4 groups with 10 rats in each group. The high-fat feed formula is as follows: lard 10%, cholesterol 2%, propylthiouracil 0.2%, pig bile salt 0.5%, and basic feed 87.3%. Animals were fed high-fat feed for modeling (except for the normal group) and given pefloxacin for 19 consecutive days. On the 20th day, the rats were anesthetized with 25% urethane (0.4ml / 100g), blood was collected from the abdominal aorta, and the serum was centrifuged to determine triglycerides (TG), cholesterol (CHO), and high-density lipoprotein (HDL-C). ), low-density lipoprotein (LDL-C), the results are shown in Table 1 and Table 2. From Table 1, it can be seen that pefloxacin can significantly reduce the content of triglycerides and cholesterol in the serum of high-fat r...

Embodiment 2

[0029] Example 2: Obesity model formed by feeding Kunming mice with high fat feed

[0030] Forty 6-week-old male Kunming mice (18-22g) were kept in a dry, clean and well-ventilated environment at a temperature of (24±1)℃. The mice were randomly divided into 4 groups, each with 10 mice. The mice in each group were raised in separate cages, and there was no significant difference in body weight. The blank control group was fed basic feed, and the other groups were fed high-fat feed. After 1 week of pre-feeding, the blank group: fed basic feed and gavage normal saline; positive control group: fed high-fat feed and gavage atorvastatin 10mg / (kg BW·d); high-fat model group: fed Feed high-fat feed and gavage normal saline; Pefloxacin group: feed high-fat feed and gavage 50mg / (kg BW·d) Pefloxacin drug solution. During the experiment, the mice in each group drink and eat freely, and are weighed every weekend. Continue feeding and gavage for 30 days. It can be seen from Table 3 that af...

Embodiment 3

[0034] Example 3: New Zealand white rabbits fed high-fat diet to form atherosclerosis model

[0035] Forty male New Zealand white rabbits weighing 2 kg were fed adaptively for 7 days. The animals were stratified by body weight and then randomly divided into 4 groups using a random number table, each with 10 rabbits. Animals were fed high-fat diets (except for the normal group) and were given pefloxacin or the positive drug atorvastatin for 2 consecutive months. After the experiment, blood was collected from the ear vein, and the serum was centrifuged to determine TG and CHO; the experimental results are shown in Table 3. From Table 3, it can be seen that pefloxacin can significantly reduce TG and CHO in the serum of high-fat white rabbits. The effect of floxacin in reducing triglycerides was significantly better than that of the atorvastatin group; the aorta and liver were separated, and oil red staining and HE staining were performed respectively. The effects of each group on th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of biomedicine, and discloses a use of pefloxacin in the preparation of drugs for treatment and prevention of hyperlipemia or atherosclerosis. The pefloxacin can beprepared into any pharmaceutically acceptable preparation, and a new medical use of pefloxacin compounds is opened up, the current deficiencies in the drugs for the treatment and prevention of the hyperlipemia or the atherosclerosis are overcome, and a therapeutic role is achieved from anti-inflammatory and lipid-lowering ways; and meanwhile, the pefloxacin is a clinically verified broad-spectrumantibacterial drug, wide in source, low in price, high in pharmacological effect and high in safety, and belongs to the new use of old drugs, and an economical and safe drug choice is provided for themajority of patients with cardiovascular disease.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the use of pefloxacin in the preparation of drugs for treating and preventing hyperlipidemia or atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a common cardiovascular disease in modern society. It is mainly manifested as lipid deposition in the arterial intima, intimal fibrosis, and atherosclerotic plaque formation, which leads to hardening of the tube wall and lumen Stenosis, in turn, causes a series of secondary lesions, especially ischemic diseases in the cardiovascular and cerebrovascular areas, and is the number one killer of human beings in today's society. [0003] The pathogenesis of atherosclerosis is complex, and hyperlipidemia and inflammation are considered to be the two most important pathogenic factors. The current main strategy for preventing and treating atherosclerosis is lipid-lowering. There are five commonly used lipid-lowering drugs: st...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/496A61P3/06A61P9/10
CPCA61K31/496A61P3/06A61P9/10
Inventor 杜巍胡大军彭咏波
Owner CHENZHOU NO 1 PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap