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A stable oil-soluble polypeptide composition and its preparation method and application

A peptide composition, oil-soluble technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of poor stability of oil-based cosmetics, limited application of peptide products, and prone to turbidity or delamination, etc. problem, to achieve the effect of easy storage, safe formula, and not easy to grow bacteria

Active Publication Date: 2022-05-10
ZHUHAI JINBAIKANG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many oil-based formula products in cosmetics, such as essential oils, hair oils, massage oils and various make-ups. Limit the application of peptide products in oily cosmetics
[0004] The peptides added to some oily cosmetics in the prior art are also extremely unstable, very sensitive to temperature, and prone to discoloration, turbidity or layering
In addition, the stability of oily cosmetics after adding peptides to oily cosmetics in the prior art is also poor, and turbidity or layering are prone to occur

Method used

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  • A stable oil-soluble polypeptide composition and its preparation method and application
  • A stable oil-soluble polypeptide composition and its preparation method and application
  • A stable oil-soluble polypeptide composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Prepare 1Kg of stable oil-soluble polypeptide composition with anti-wrinkle and anti-aging functions

[0036] The formulation of the oil-soluble polypeptide composition is shown in Table 1.

[0037] Table 1:

[0038] name Recipe amount palmitoyl tripeptide-1 0.1g palmitoyl tetrapeptide-7 0.05g Ethylhexylglycerin 100g Sorbitan Laurate 10g Ethylhexyl palmitate 889.85g

[0039] A stable oil-soluble polypeptide composition, comprising the following preparation methods:

[0040] (1) Weigh each component according to the formula quantity, mix palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ethylhexylglycerin, sorbitan laurate, and fully stir to obtain the mixture;

[0041] (2) Add ethylhexyl palmitate to the mixture prepared in step (1), and continue stirring and mixing to obtain an oil-soluble polypeptide composition.

[0042] The prepared stable oil-soluble polypeptide composition is a clear and transparent colorl...

Embodiment 2

[0043] Example 2: Preparation of 1Kg of stable oil-soluble polypeptide composition with black hair and bright hair function

[0044] The formulation of the oil-soluble polypeptide composition is shown in Table 2.

[0045] Table 2:

[0046] name Recipe amount Palmitoyl Tetrapeptide-10 0.1g polyoxyethylene oxypropylene oleate 100g Glyceryl Caprylate 10g Octyl methicone 889.9g

[0047] A stable oil-soluble polypeptide composition, comprising the following preparation methods:

[0048] (1) Weigh each component according to the formula quantity, mix palmitoyl tetrapeptide-10, polyoxyethylene oxypropylene oleate, and glycerin caprylate, and fully stir to obtain a mixture;

[0049] (2) Add octyl polymethicone to the mixture prepared in step (1), and continue stirring and mixing to obtain an oil-soluble polypeptide composition.

[0050] The prepared stable oil-soluble polypeptide composition is a clear and transparent colorless to pale yellow ...

Embodiment 3

[0051] Embodiment 3: Preparation 1Kg has the stable oil-soluble polypeptide composition that promotes the synthetic function of collagen and hyaluronic acid

[0052] The formulation of the oil-soluble polypeptide composition is shown in Table 3.

[0053] table 3:

[0054] name Recipe amount palmitoyl tripeptide-1 1g fatty acid polyoxyethylene ester 100g beeswax 100g Tribehenin 200g Isohexadecane 599g

[0055] A stable oil-soluble polypeptide composition, comprising the following preparation methods:

[0056] (1) Palmitoyl tripeptide-1 and polyoxyethylene fatty acid ester are added to the batching tank and mixed, fully stirred to obtain mixture A;

[0057] (2) Add isohexadecane to the mixture A prepared in step (1), stir well, and heat to 70°C to obtain mixture B, which is set aside;

[0058] (3) Heat beeswax and tribehenin to 75°C, then add to mixture B, stir evenly, and cool to room temperature (for example, 25°C) to obtain an o...

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Abstract

The invention belongs to the field of cosmetics and discloses a stable oil-soluble polypeptide composition, comprising the following components: polypeptide, solubilizer, and oily solvent; the octanol-water partition coefficient of the solubilizer is 1.70-1.90 or the HLB value is 8.0 ‑10.0; the polypeptide is selected from palmitoyl dipeptide‑7, palmitoyl tripeptide‑1, palmitoyl tripeptide‑5, palmitoyl tripeptide‑8, palmitoyl tetrapeptide‑5, palmitoyl tetrapeptide‑7, At least one of palmitoyl tetrapeptide-10 and palmitoyl pentapeptide-4; the solubilizer is selected from ethylhexylglycerin, glyceryl caprylate, fatty acid polyoxyethylene ester, sorbitan laurate and poly At least one of oxyethylene oxypropylene oleate. The oil-soluble polypeptide composition of the present invention is easy to add to cosmetics with full oil formula, and has good compatibility. The oil-soluble polypeptide composition has good stability and is not easy to grow bacteria. Compared with traditional water-soluble polypeptide products, it does not need to add Preservatives, the formula is safer.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a stable oil-soluble polypeptide composition and its preparation method and application. Background technique [0002] Peptides with biological activity have broad application prospects in skin beauty and skin care because of their small molecular weight, easy absorption, good stability, and good beauty and skin care functions. [0003] Cosmetic peptide products on the market are generally freeze-dried powders. In addition, for the convenience of use, most cosmetic raw material manufacturers will prepare peptide products into aqueous solution dosage forms. However, there are many oil-based formula products in cosmetics, such as essential oils, hair oils, massage oils and various make-ups. The application of peptide products in oily cosmetics is limited. [0004] The peptides added to some oily cosmetics in the prior art are also extremely unstable, very sensitive to temperature, and pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/37A61K8/891A61K8/86A61Q19/00A61Q1/00
CPCA61K8/64A61K8/375A61K8/37A61K8/891A61K8/86A61Q19/00A61Q1/00A61K2800/10
Inventor 胡波波莫敏慧陈显春吴文君夏玉平赖红星
Owner ZHUHAI JINBAIKANG BIOLOGICAL TECH CO LTD
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