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Extraction process of ginkgolic acid

A technique for extracting ginkgolic acid and its extraction process, which is applied in the field of extracting process for ginkgolic acid, can solve problems such as environmental pollution and waste of resources, and achieve the effects of less solvent loss, low cost, and simple extraction process

Inactive Publication Date: 2019-10-22
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ginkgo biloba testa is the outer part of the hard shell of ginkgo seeds, commonly known as ginkgo seed coat, which accounts for 70% of the whole seed, and can only be obtained in the place of origin, and when the place of origin collects ginkgo fruit, it is often discarded as waste. Not only waste resources, but also pollute the environment

Method used

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  • Extraction process of ginkgolic acid
  • Extraction process of ginkgolic acid
  • Extraction process of ginkgolic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Example 1: Extraction of Phenolic Acids in Ginkgo Exocarp

[0027] The extraction steps of phenolic acids in Ginkgo biloba testa are:

[0028] S1: Material selection and pretreatment

[0029] The collected ginkgo testa is vacuum-dried in a DZF-6021 vacuum drying oven at 60°C, mechanically crushed, passed through a 40-mesh sieve, and placed in a desiccator for subsequent use;

[0030] AB-8 macroporous resin, HPD-100 macroporous resin, D101 macroporous resin, X-5 macroporous resin, NKA-9 macroporous resin, LSA-20 macroporous resin, LSA-30 macroporous resin, D201 macroporous resin Porous resin, SP70 macroporous resin and Z TC-1 macroporous resin 10 soaked with 95% ethanol for 24h, then wet-packed with 95% ethanol, washed with 95% ethanol until the effluent was added Distilled water with a mass ratio of 1:3 has no white turbidity, and then washed with a large amount of distilled water until there is no alcohol smell, poured out, and dried in a vacuum drying cabinet at 60°...

Embodiment 2

[0049] Embodiment two: the extraction of total phenolic acid in ginkgo leaf industrial waste residue

[0050] In S1, the industrial waste residue of ginkgo biloba is vacuum-dried in a DZF-6021 vacuum drying oven at 60°C, mechanically crushed, passed through a 40-mesh sieve, and placed in a desiccator for later use;

[0051] Other steps were the same as in Example 1, and the total phenolic acid extract was designated as sample II.

Embodiment 3

[0052] Example Three: Extraction of Total Phenolic Acids in Ginkgo Leaf Industrial Waste Liquid

[0053] In S1, the ginkgo biloba industrial waste liquid is first filtered with a 0.45μ membrane, the filtrate is vacuum rotary evaporated, and after the organic solvent is recovered, the remaining liquid is used for later use;

[0054] In S3, add 95% ethanol to the remaining liquid of S1, adjust the concentration to 80%, reflux at 60°C for 4 hours, extract 3 times, combine the extracts, filter with a 0.45μ membrane, and reserve the filtrate for later use;

[0055] Other steps are also the same as in Example 1, and the total phenolic acid extract is designated as sample III.

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Abstract

The invention discloses an extraction process of a ginkgolic acid. The process includes the steps of material selection and pretreatment, making of a standard curve, preparation of a ginkgolic acid extract, extraction of total ginkgolic acids, measurement of a phenolic acid in the total ginkgolic acids, and measurement of the content and extraction rate of the phenolic acid in raw materials of ginkgo biloba. D101 macroporous resin is soaked in ethanol, a column is filled with the D101 macroporous resin in a wet manner and rinsed, and the D101 macroporous resin is poured out and then dried; thetesta of the ginkgo biloba is dried under vacuum, mechanically pulverized and then sifted, 80% ethanol is added for reflux extraction three times at 60 DEG C for 4 hours, and extracts are combined and filtered; the pretreated resin is added into a combined extract, ethanol is recovered after rotary evaporation, the pretreated resin is washed with distilled water and then eluted with the ethanol,the ethanol is recovered after an ethanol eluate is subjected to rotary evaporation, residues are dried under vacuum, and the total ginkgolic acids of the testa of the ginkgo biloba are obtained. By adopting the process for extracting the ginkgolic acid from the testa of the ginkgo biloba, the yield of the total ginkgolic acids is 7.0, the extraction rate is 92%, and the content of the phenolic acid in the extract is 39.5%.

Description

technical field [0001] The invention relates to the field of chemical process extraction, in particular to an extraction process of ginkgophenolic acid. Background technique [0002] Ginkgolic acid belongs to urushiol, which is a derivative of 6-alkyl or 6-alkenyl salicylic acid, widely present in ginkgo leaves, outer testa and seed kernels, mainly in the outer testa of ginkgo , can be divided into ginkgolic acid (ginkgolic acid, hydrogenated ginkgo acid, hydrogenated ginkgo acid), gingkool, ginkgodiol. Ginkgolic acid has immunotoxicity, cytotoxicity and sensitization, and is the main poisoning substance in Ginkgo biloba extract and its preparations. Ginkgo biloba testa is the outer part of the hard shell of ginkgo seeds, commonly known as ginkgo seed coat, which accounts for 70% of the whole seed, and can only be obtained in the place of origin, and when the place of origin collects ginkgo fruit, it is often discarded as waste. Not only waste resources, but also pollute t...

Claims

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Application Information

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IPC IPC(8): A61K36/16
CPCA61K36/16A61K2236/33A61K2236/51A61K2236/55
Inventor 张素军
Owner LINYI UNIVERSITY
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