A temperature-sensitive supramolecular polymer regulated by multiple hydrogen bonds and its preparation method

Abstract

The invention relates to a functional polymer material, and aims to provide a temperature-sensitive supramolecular polymer regulated by multiple hydrogen bonds and a preparation method thereof. The present invention further provides the preparation method of aforementioned temperature-sensitive supramolecular polymer, is to introduce supramolecular group 2-ureido-4-[1H at the end of polyethylene glycol / polyethylene lactide three-block copolymer ]‑pyrimidinone, and the latter forms a supramolecular polymer through self-complementary quadruple hydrogen bonding; the supramolecular polymer exhibits temperature sensitivity in aqueous solution, and realizes the polymerization of Regulation of temperature sensitivity. The method of the invention is simple and easy to implement, and has high implementability. The use of UPy's quadruple hydrogen bonds to construct supramolecular polymer materials can effectively regulate the temperature-sensitive behavior of polymer materials, and the method is novel and expands its application range. The raw materials used are all from renewable biomass resources, can be completely degraded after use, are green and environmentally friendly, and have good biocompatibility.

Description

Technical field [0001] The present invention belongs to the field of functional polymer materials, specifically relates to a temperature-sensitive supramolecular polymer regulated by multiple hydrogen bonds and a preparation method thereof. Background [0002] Thermosensitive polymers are functional polymer materials that can respond to subtle changes in the temperature of the external environment and produce corresponding changes in physical structure and chemical properties. Using the temperature responsiveness characteristics of polymers, it is possible to design a smart material with temperature response as needed. Amphiphilic copolymers typically exhibit temperature-sensitive behavior, that is, at room temperature, the polymer can be dissolved in water to form a uniform solution, when the temperature rises to a certain temperature, the solution is phase separation, the solution is turbid, when the temperature is cooled below the temperature transition point, the polymer solu...

AI Technical Summary

Problems solved by technology

[0004] For PLGA-PEG-PLGA temperature-sensitive polymer materials, its LCST is an important indicator affecting its biomedical application. The current method of regulating the polymer LCST is mainly to regulate the composition of hydrophilic and hydrophobic segments. However, the above-mentioned technologies still exist. The following technical defects: the temperature sensitivity of the polymer is regulated simply by adjusting the composition of the hydrophilic and hydrophobic segments, the control range is limited, the ratio of the hydrophilic and hydrophobic segments must be properly regulated, and too many hydrophilic monomers will increase the LCST Even disappear, too much hydrophobic monomer will greatly reduce the LCST of the polymer, which limits the scope of use of temperature-sensitive polymers

At the same time, the temperature sensitivity of the polymer is regulated by hydrophobic interaction, the force is relatively single, the degree of chain entanglement is low, the chain segments are loosely packed, and the stability of the polymer is poor.

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