Double-wall porous microcapsule probiotic sphere and preparation method thereof

A technology of microcapsules and porous hydrogels, applied in the direction of bacteria, bifidobacteria, streptococci/lactococci, etc. used in food preparation, can solve the problem of easy damage to the single wall, small load of probiotics, loss of probiotics, etc. Live and other issues, to achieve the effect of ensuring the number of viable bacteria, increasing the load of probiotics, and strengthening the interaction

Inactive Publication Date: 2019-11-12
TIANJIN NONGKE FOOD BIO TECH & SCI
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  • Abstract
  • Description
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Problems solved by technology

Disadvantages: ①The nutritional environment of the core material is poor, and the reproduction rate of bifidobacteria is low; ②The single-layer wall is easily destroyed in the low-acid environment of the stomach, and a large number of probiotics are inactivated; ③The load of probiotics is small
Disadvantages: ①The nutritional environment of the core material is poor, and the reproduction rate of bifidobacteria is low; ②The single-layer wall is easily destroyed in the low-acid en

Method used

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  • Double-wall porous microcapsule probiotic sphere and preparation method thereof
  • Double-wall porous microcapsule probiotic sphere and preparation method thereof

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Embodiment Construction

[0033] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0034] A double-wall porous microcapsule probiotic ball and a preparation method thereof, the steps are as follows:

[0035] ⑴ Bifidobacteria culture solution preparation:

[0036]B. Longum bacteria liquid was inoculated in lactic acid bacteria medium (MRS), anaerobically cultured at 37°C for 12h after nitrogen filling, and centrifuged at 4°C and 6000r / min for 10min. After decanting the supernatant, the cell pellet was washed twice with 0.85% normal saline and resuspended in normal saline, and the cell concentration was adjusted to 2×10 9 CFU ml.

[0037] ⑵Preparation of bacterial complex solution:

[0038] 6 parts of bifidobacterium culture solution, 1 part of lactis streptococcus, 2 parts of soybean oligosaccharides (mainly including st...

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Abstract

The invention relates to a double-wall porous microcapsule probiotic sphere and a preparation method thereof. A double wall layer self-assembled surface modification core material is adopted, an innerwall material is based on nano calcium carbonate and combined with ultrasonic oscillation to prepare porous hydrogel to increase capacity, so that a small part of the contiguous calcium carbonate isdispersed and loosened, agglomeration is avoided, and the probiotic load is significantly improved; an outer wall is coated with protein-polysaccharide compound gel, charge neutralization is driven byelectrostatic force to generate condensation, a compound with superior functional properties than proteins and polysaccharides is formed, thus the adsorption behavior of the proteins on an interfaceand rheological properties of an interfacial adsorption film are changed, microencapsulation of the wrapped core material is realized, and stability of a microcapsule is improved.

Description

technical field [0001] The invention belongs to the technical field of microcapsules, in particular to a double-wall porous microcapsule probiotic ball and a preparation method thereof. Background technique [0002] Bifidobacteria are the most important beneficial bacteria in the human intestinal tract, which is of great significance to maintaining the micro-ecological balance and normal physiological functions of the human intestinal tract and promoting human health. However, bifidobacteria are anaerobic bacteria and are not tolerant to strong acid environments. When they are taken orally into the human stomach, most of them are inactivated by gastric acid, bile and digestive enzymes, so it is difficult to effectively treat the human body. Therapeutic or health effects. [0003] Microencapsulated probiotics embedding technology is relatively practical at this stage, but there are still many difficult problems to overcome. Most of the microencapsulated probiotics on the ma...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23P10/30A23L5/30A23L29/00A23L29/30
CPCA23L33/135A23P10/30A23L29/015A23L5/32A23L29/045A23L29/30A23V2002/00A23V2400/231A23V2400/51A23V2200/30A23V2250/06A23V2250/28A23V2250/5116A23V2250/5488A23V2250/5036A23V2300/48
Inventor 李喜宏熊忠飞
Owner TIANJIN NONGKE FOOD BIO TECH & SCI
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