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A nitric oxide releasing ointment and its preparation method and application

A technology of nitric oxide and ointment, applied in the field of pharmaceutical materials and biomedical materials, can solve problems such as large side effects and drug resistance of the body, and achieve the effects of lightening the burden, no skin irritation, and prolonging the release time of NO.

Active Publication Date: 2021-12-17
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the ointments used in the market to treat skin diseases caused by pathogenic bacteria infection are basically antibiotic ointments, which have relatively large side effects and can easily lead to problems such as drug resistance in the body

Method used

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  • A nitric oxide releasing ointment and its preparation method and application
  • A nitric oxide releasing ointment and its preparation method and application
  • A nitric oxide releasing ointment and its preparation method and application

Examples

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preparation example Construction

[0046] The anhydrous methanol described in the examples of the present application is prepared by the following method: calcium hydride is added to methanol, stirred for 12 hours, and then distilled at atmospheric pressure to obtain anhydrous methanol. 1 gram meter.

[0047] The anhydrous ether was prepared by the following method: calcium hydride was added to ether, stirred for 12 hours, and then distilled under atmospheric pressure to obtain anhydrous ether, and the amount of calcium hydride added was 1 gram per 500 mL of ether.

[0048] The anhydrous tetrahydrofuran was prepared by the following method: calcium hydride was added to tetrahydrofuran, stirred for 12 hours, and then distilled at atmospheric pressure to obtain anhydrous tetrahydrofuran, and the amount of calcium hydride added was 1 gram per 500 mL of tetrahydrofuran.

[0049] The dry polyethyleneimine is prepared by the following method: weigh a certain amount of polyethyleneimine PEI in a vacuum drying oven, pl...

Embodiment 1

[0052] (1) Preparation of polyethyleneimine (PEI) NO donor material PEI / NONOate

[0053] Under the condition of room temperature and 35°C, a certain quality of dry polyethyleneimine (number average molecular weight is 600) is dissolved in a mixed solution of anhydrous methanol and tetrahydrofuran (the volume ratio of anhydrous methanol and tetrahydrofuran is 1:1), and the The amount of water and methanol is based on dissolving 0.1g PEI per 10mL. After dissolving for 5 minutes, add dry sodium methoxide, wherein the mass ratio of polyethyleneimine PEI and sodium methoxide is 1:10. After continuing to dissolve and stabilize for 30 minutes, a mixed solution is obtained. The mixed solvent is added into the autoclave, sealed and tested for air tightness. High-purity nitrogen was maintained in the reactor (20 psi) for 20 minutes to remove the air in the reactor, and then NO gas (80 psi) was introduced, and the reaction was carried out at room temperature at 35° C. for 7 days. After ...

Embodiment 2

[0081] Preparation of polyethyleneimine (PEI) NO donor material PEI / NONOate

[0082] Under the condition of room temperature and 25°C, take a certain quality of dry polyethyleneimine (number average molecular weight is 70000) and dissolve it in the mixed solution of anhydrous methanol and tetrahydrofuran (the volume ratio of anhydrous methanol and tetrahydrofuran is 1:2). The amount of water and methanol is based on 0.5g PEI per 10mL dissolved. After dissolving for 30 minutes, add dry sodium methoxide, wherein the mass ratio of polyethyleneimine PEI and sodium methoxide is 1:100. After continuing to dissolve and stabilize for 60 minutes, a mixed solution is obtained. The mixed solvent is added into the autoclave, sealed and tested for air tightness. High-purity nitrogen was maintained in the reactor (50 psi) for 10 minutes to remove the air in the reactor, and then NO gas (120 psi) was introduced to react at room temperature at 25° C. for 3 days. After the reaction was finish...

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Abstract

The invention discloses a nitric oxide releasing ointment, a preparation method and application thereof. The method comprises the following steps: (1) dissolving polyethyleneimine in an organic solvent, adding sodium methoxide, mixing uniformly, carrying out NO loading reaction, and obtaining polyethyleneimine NO donor material; (2) dissolving polyethyleneimine NO donor material The body material is dissolved in polyvinyl alcohol aqueous solution to obtain polyethyleneimine NO donor material solution; (3) liquid paraffin, glyceryl monostearate, white vaseline and lanolin are mixed uniformly to obtain an oil phase; glycerin, Add Span 80 and Tween 80 into water and mix evenly to obtain a water phase; add the water phase to the oil phase to obtain a mixed solution; (4) add polyethyleneimine NO donor material solution to the mixed solution to obtain a released Nitric oxide ointment. The prepared ointment has good antibacterial and slow release effects on various bacteria, and is of great significance for the treatment of various microbial diseases and the improvement of people's health.

Description

technical field [0001] The invention belongs to the field of pharmaceutical materials and biomedical materials, and in particular relates to a nitric oxide releasing ointment and a preparation method and application thereof. Background technique [0002] Skin diseases caused by microbial infections such as bacteria / fungi are currently a serious global challenge, not only threatening public health security, but also causing a heavy economic burden. Accumulation of pathogenic bacteria on susceptible skin surfaces or wounds leading to infection leads to a dramatic increase in toxins on the skin surface or wound, which may significantly prolong or interfere with the skin wound healing process, and may even lead to Skin wounds are further aggravated, leading to more serious consequences. In addition, severe microbial / bacterial / fungal infections can lead to failure of surgical medical implants and devices, greatly increasing the risk of sepsis and even death. The problem is furt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K33/00A61K47/06A61K47/32A61K47/44A61P17/00A61P17/02A61P31/04A61P31/10
CPCA61K9/06A61K47/06A61K47/32A61K9/0014A61K47/44A61P31/04A61P31/10A61P17/00A61P17/02A61K33/00
Inventor 马栋李国巍张武
Owner JINAN UNIVERSITY
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