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Ulcerative colitis repair probiotic microcapsule preparation

A microcapsule and microecological technology, applied in microcapsules, capsule delivery, medical preparations with inactive ingredients, etc., can solve the problems of unclear pathogenesis, unsuitable for long-term treatment, etc., and achieve the goal of improving physiological indicators and reducing activity. Effect

Pending Publication Date: 2019-11-15
QINGDAO AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the exact pathogenesis of UC remains unclear, and existing treatments, such as antibiotics, corticosteroids, and immunomodulators, have achieved some success; drug therapy is not suitable for long-term treatment due to its side effects

Method used

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  • Ulcerative colitis repair probiotic microcapsule preparation
  • Ulcerative colitis repair probiotic microcapsule preparation
  • Ulcerative colitis repair probiotic microcapsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of Bifidobacterium adolescentis microcapsules and Clostridium butyricum microcapsules

[0022] 1) Selection of wall materials:

[0023] The wall materials used for the microcapsule coating of strains include: chitosan, sodium carboxymethylcellulose and fructooligosaccharides. Among them, chitosan is a biological natural polymer with mucoadhesive properties. Sodium carboxymethylcellulose (NaCMC) is an anionic derivative of cellulose with mucoadhesive properties. FOS is a prebiotic that can promote the growth and reproduction of probiotics such as bifidobacteria. The agent with chitosan matrix exists in the form of gel at low pH to prevent the diffusion of bioactive agents, so that the embedded probiotics can pass through the harsh environment of the gastrointestinal tract smoothly and maintain sufficient bacterial activity.

[0024] 2) Selection and cultivation of strains:

[0025] The strains were Bifidobacterium adolescentis (BNCC 134301) ...

Embodiment 2

[0027] Embodiment 2: the effect detection of composition

[0028] 1) Compounding of the composition

[0029] The bacterial activity of Bifidobacterium adolescentis (BNCC 134301) microcapsules and Clostridium butyricum (BNCC 337239) microcapsules adopted in the present invention is respectively 1 * 10 8 CFU / rat / day~5×10 8 CFU / rat / day, the addition ratios were 1:1, 5:1, 1:5 and 5:5.

[0030] 2) Experimental animals and experimental design

[0031] In the experiment, 126 adult male SD rats aged 7 weeks were randomly divided into 7 groups, with 3 repetitions in each group and 6 rats in each repetition. The seven groups were BaCb(1:1) group, BaCb(5:1) group, BaCb(1:5) group, BaCb(5:5) group, wall material group, DSS group and normal group (see Table 1 ). On the 1st-14th day, the BaCb(1:1) group, BaCb(5:1) group, BaCb(1:5) group and BaCb(5:5) group administered the composition to the rats, and the wall material group The microcapsules without probiotics were administered intra...

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Abstract

The invention relates to a colitis-repair microbiological microcapsule preparation. The composition for treating colitis is joint use of bifidobacterium adolescentis microcapsules and clostridium butyricum microcapsules. The microbiological microcapsule composition is used for intervention of rats, DSS is used for inducing to form ulcerative colitis, changes in respects of the weight, the colon length, the inflammatory factor, the intestine microorganisms and the like of groups of rats are assessed, and prevention effects of the composition on colitis are researched. Test results prove that the composition can improve the physiological index of colitis rats, can reduce the content of intestine inflammatory factors of TNF-alpha, IL-6 and the like, can reduce the activity of marrow peroxidase, and can regulate the flora structure of intestines. The colitis-repair microbiological microcapsule preparation has the characteristics that the microbiological microcapsule is safe, non-toxic andfree from side effects. Compared with medication by adopting antibiotics and the like, the colitis-repair microbiological microcapsule preparation has certain advantages. For the reason, the inventionprovides an important technical support for development of a novel colitis prevention preparation.

Description

technical field [0001] The invention belongs to the technical field of preparations for treating enteritis, and in particular relates to a probiotic microcapsule preparation for repairing ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease of the colon and rectum. At present, the incidence of the disease is getting higher and higher. In the past, it occurred frequently in western countries, but with the change of diet structure, the incidence rate in our country is also increasing. The main clinical manifestations are abdominal pain, diarrhea, pus and blood in the stool and so on. Studies have shown that the pathogenesis of UC may be related to genetics, immune regulation, environment and intestinal microorganisms. However, the exact pathogenesis of UC remains unclear, and existing treatments, such as antibiotics, corticosteroids, and immunomodulators, have achieved some success; due to the side effects of...

Claims

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Application Information

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IPC IPC(8): A61K35/745A61K9/50A61K47/36A61K47/38A61K47/26A61K47/10A61P1/00A61P1/04A61K35/742
CPCA61K35/745A61K35/742A61K9/5036A61K9/5047A61K9/5015A61P1/00A61P1/04A61K2300/00Y02A50/30
Inventor 王宝维王文杰葛文华张名爱岳斌
Owner QINGDAO AGRI UNIV
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