Injection for treating piglet diarrhea and production method of injection for treating piglet diarrhea

A technology for piglet diarrhea and injection, which is applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., to protect the intestines, promote the loss of nutrients, and weaken the stress response.

Inactive Publication Date: 2019-11-29
长沙凯泽工程设计有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an injection for treating piglet diarrhea and its preparation me

Method used

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  • Injection for treating piglet diarrhea and production method of injection for treating piglet diarrhea
  • Injection for treating piglet diarrhea and production method of injection for treating piglet diarrhea
  • Injection for treating piglet diarrhea and production method of injection for treating piglet diarrhea

Examples

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Embodiment 1

[0025] A method for preparing an injection for treating piglet diarrhea. Firstly, a main drug is used to construct a slow-release loading system, and then dissolved in water for injection to obtain the injection for treating piglet diarrhea; wherein, the main drug includes Flufloxacin, L-tryptophan and mannan oligosaccharides; the construction method of the slow-release load system is as follows: in parts by weight, first prepare 8 parts of plant starch into starch milk, gelatinize, cool to 50 ° C, add Prolu Lanzyme, enzymatic hydrolysis reaction, heat to dissolve, add 1 part of norfloxacin, then quickly precipitate with absolute ethanol, centrifuge, the obtained solid is dissolved in 12 parts of pH=7.1 phosphate buffer, add 0.08 part of mannan oligosaccharide, Stir and dissolve to obtain the water phase; then dissolve 20 parts of soybean lecithin for injection and 15 parts of cholesterol in 30 parts of ether as the organic phase; then add the water phase to the organic phase d...

Embodiment 2

[0033]A method for preparing an injection for treating piglet diarrhea. Firstly, a main drug is used to construct a slow-release loading system, and then dissolved in water for injection to obtain the injection for treating piglet diarrhea; wherein, the main drug includes Flufloxacin, L-tryptophan and mannan oligosaccharides; the construction method of the slow-release loading system is as follows: in parts by weight, first prepare 10 parts of plant starch into starch milk, gelatinize, cool to 50 ° C, add Pullulanase, enzymatic hydrolysis reaction, heat to dissolve, add 1 part of norfloxacin, then quickly precipitate with absolute ethanol, centrifuge, the obtained solid is dissolved in 15 parts of pH=7.5 phosphate buffer, add 0.1 part of mannooligo Sugar, stirred and dissolved to obtain the water phase; then 25 parts of soybean lecithin for injection and 20 parts of cholesterol were dissolved in 40 parts of ether as the organic phase; then the water phase was added dropwise to ...

Embodiment 3

[0041] A method for preparing an injection for treating piglet diarrhea. Firstly, a main drug is used to construct a slow-release loading system, and then dissolved in water for injection to obtain the injection for treating piglet diarrhea; wherein, the main drug includes Flufloxacin, L-tryptophan and mannan oligosaccharides; the construction method of the slow-release loading system is as follows: in parts by weight, first prepare 8 parts of plant starch into starch milk, gelatinize, cool to 50 ° C, add Pullulanase, enzymatic hydrolysis reaction, heat to dissolve, add 1 part of norfloxacin, then quickly precipitate with absolute ethanol, centrifuge, the obtained solid is dissolved in 15 parts of pH=7.1 phosphate buffer, add 0.1 part of mannooligo Sugar, stirred and dissolved to obtain the water phase; then 20 parts of soybean lecithin for injection and 20 parts of cholesterol were dissolved in 30 parts of ether as the organic phase; then the water phase was added dropwise to ...

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Abstract

The invention provides an injection for treating piglet diarrhea and a production method of the injection for treating piglet diarrhea. Firstly, main drugs are used for building a slow-release loadingsystem, and then the built slow-release loading system is dissolved in water for injection to obtain the injection for treating piglet diarrhea; the main drugs comprise norfloxacin, L-tryptophan andmannan oligosaccharide. A building method of the slow-release loading system comprises the following steps: firstly, producing starch milk from plant starch, conducting gelatinization and cooling, adding pullulanase, carrying out an enzymolysis reaction, conducting heating for dissolution, adding the norfloxacin, then with absolute ethyl alcohol used for fast sedimentation, conducting centrifugation, dissolving obtained solid in a phosphate buffer solution, adding the mannan oligosaccharide, and conducting stirring for dissolution to obtain an aqueous phase; then dissolving soyabean lecithin for injection and cholesterol in diethyl ether to obtain an organic phase; and then adding the aqueous phase into the organic phase dropwise while conducting stirring, adding the L-tryptophan, conducting stirring, conducting rotary evaporation to remove the diethyl ether so as to obtain a concentrate, adding the concentrate into a 2-hydroxypropyl-beta-cyclodextrin aqueous solution while conductingstirring, and conducting stirring until the concentrate is completely dissolved so as to obtain the slow-release loading system. The obtained injection can effectively treat piglet diarrhea, and frequent dosing is avoided.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to an injection for treating diarrhea in piglets and a preparation method thereof. Background technique [0002] With the large-scale and intensive development of pig breeding, the weaning age of piglets in pig farming has been gradually shortened from the traditional 60 days to 35 days, or even 21 days. Although early weaning of piglets can improve the reproductive rate of sows, it also brings a lot of weaning syndrome. Digestion and absorption of protein and fat in food is relatively poor, which is especially easy to cause digestive disorders, leading to a series of problems such as loss of appetite and diarrhea. [0003] Piglet diarrhea is a typical multi-pathogenic disease under intensive pig production conditions. It occurs repeatedly from the beginning of winter to the beginning of spring, the incidence rate is high, and the course of disease is 5 to 10 days. Si...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/08A61K31/702A61K31/496A61P31/04A61K31/405
CPCA61K9/0019A61K9/08A61K31/405A61K31/496A61K31/702A61K47/6951A61P31/04A61K2300/00
Inventor 不公告发明人
Owner 长沙凯泽工程设计有限公司
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