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Selenized konjac oligo-glucomannan and preparation and application thereof

A technology of glucomandioligosaccharides and glucomanoligosaccharides, which is applied in the field of selenized konjac glucomanoligosaccharides, can solve the problems of no selenized konjac glucomanoligosaccharides, etc., and achieve anti-aging health food, high selenium content, inhibition The effect of cancer care drugs

Inactive Publication Date: 2019-12-03
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the preparation of konjac glucomanoligosaccharides at home and abroad, and there is no report on the selenization of konjac glucomanoligosaccharides

Method used

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  • Selenized konjac oligo-glucomannan and preparation and application thereof
  • Selenized konjac oligo-glucomannan and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 selenized konjac glucomannan oligosaccharides

[0030] Add 0.5g of konjac glucomannan oligosaccharide to 50mL of 0.5% nitric acid aqueous solution, stir to dissolve; add 0.61g of sodium selenite, 0.86g of barium chloride, stir to dissolve; react the solution at 70°C for 9 hours; add 0.5 g sodium sulfate, centrifuged at 8000rpm to remove the precipitate; the supernatant was neutralized to neutral with sodium bicarbonate; 5 times the volume of ethanol was added to the reaction solution to produce a large amount of white precipitate; the solid was obtained by suction filtration, and dried at 60°C in a vacuum desiccator. The white powder selenized konjac glucomannan oligosaccharide was obtained.

[0031] The selenized konjac glucomannan oligosaccharide is carried out infrared spectrum analysis (see attached figure 2 ), at 740cm -1 There is an obvious absorption peak at the place, which is the absorption peak of selenite, indicating that a ...

Embodiment 2

[0032] The preparation of embodiment 2 selenized konjac glucomannan oligosaccharides

[0033] Get the konjac glucomannan oligosaccharide of 0.5g embodiment 1 and join in the 0.5% phosphoric acid aqueous solution of 50mL, stir to dissolve; Add 0.81g sodium selenite, 0.86g barium chloride, stir to dissolve; The solution is reacted at 80 ℃ 6 Add 0.5g of potassium sulfate, 8000rpm centrifuge to remove the precipitate; the supernatant is neutralized to neutral with sodium carbonate; 6 times the volume of ethanol is added to the reaction solution to produce a large amount of white precipitate; the solid is obtained by suction filtration, and the 40 ℃ drying to obtain white powder selenized konjac glucomannan oligosaccharide.

[0034] Carry out infrared spectroscopic analysis to selenized konjac glucomannan oligosaccharide, at 740cm -1 There is an obvious absorption peak at the place, which is the absorption peak of selenite, indicating that a selenization reaction has taken place o...

Embodiment 3

[0035] The preparation of embodiment 3 selenized konjac glucomannan oligosaccharides

[0036] Take 0.5g of the konjac glucomannan oligosaccharide of Example 1 and add it to 50mL of 1.0% hydrochloric acid aqueous solution, stir and dissolve; add 0.821g sodium selenate, 0.91g calcium chloride, stir and dissolve; react the solution at 60°C for 10 hours ; Add 0.5g of potassium sulfate, 8000rpm centrifugation to remove the precipitate; the supernatant is neutralized to neutral with sodium hydroxide; 3 times the volume of ethanol is added to the reaction solution to produce a large amount of white precipitate; the solid is obtained by suction filtration, and the 60 ℃ drying to obtain white powder selenized konjac glucomannan oligosaccharide.

[0037] Carry out infrared spectrum analysis to selenized konjac glucomannan oligosaccharide, at 741cm -1 There is an obvious absorption peak at the place, which is the absorption peak of selenite, indicating that a selenization reaction has t...

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Abstract

The invention relates to selenized konjac oligo-glucomannan and preparation and application thereof. The weight-average molecular weight of the selenized konjac oligo-glucomannan is 350-10000 Da, andmain chains are connected through a glucosyl group and a mannose group by beta-1,4 glycosidic bonds; selenium is connected to the C6 and / or C2 and / or C3 bit of the glucosyl group or the mannose groupin the form of selenite ester; and the content of the selenium is 0.2-1.5% (w / w). A preparation method comprises the steps that the konjac oligo-glucomannan is added into an acidic aqueous solution, aselenylation reagent and a catalyst are added, then a heating reaction is conducted, sulfate is added, and precipitation is removed through centrifugation; supernatant is neutralized to be neutral through alkali; and organic alcohol is added, then suction filtration is conducted to obtain a solid, and the selenized konjac oligo-glucomannan is obtained after drying. The selenized konjac oligo-glucomannan serves as an active ingredient to be used for anti-aging health-care food, tumor-inhibition health-care drugs, anti-inflammatory drugs, or antioxidant food.

Description

technical field [0001] The invention relates to selenized konjac glucomannan oligosaccharides, in particular to selenized konjac glucomannan oligosaccharides and its preparation and application. Background technique [0002] Konjac is a perennial herbaceous plant of the Araceae family. China began to cultivate konjac more than two thousand years ago, and its edible history is quite long. Japan has a history of planting and eating for more than 1,500 years, and a history of processing konjac powder for more than 100 years. Although China has a history of folk planting for more than 2,000 years, the real processing of konjac powder only began in the mid-1980s. Konjac polysaccharide is also called konjac glucomannan (Konjac glucomannan, KGM), and konjac polysaccharide has various uses. In addition to medicine and food health care, konjac polysaccharides are widely used in textiles, printing and dyeing, cosmetics, ceramics, fire protection, environmental protection, military i...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P35/00A61P29/00A23L33/125
CPCA23L33/125A23V2002/00A61P29/00A61P35/00C08B37/0003C08B37/009A23V2200/308A23V2200/302A23V2200/30A23V2250/51
Inventor 尹恒刘启顺
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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