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Preparation method of mussel antiallergic peptide and application of mussel antiallergic peptide to cosmetics

An anti-allergic and shellfish technology, applied in the field of preparation of mussel anti-allergic peptides, can solve the problems of not involving application process technology and formula, difficult to obtain raw materials, damage of functional components, etc., and achieve excellent anti-allergic ability and excellent free radicals. Clearing, high active ingredient effect

Active Publication Date: 2020-01-03
广州市尚梓化工科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The processing process of the active peptide prepared above has disadvantages such as low extraction efficiency, destruction of functional components, organic solvent residues, etc., and there are disadvantages such as difficult acquisition of raw materials, high cost, and complicated preparation process, which does not involve actual application technology and formula, and there is no report on the application of mussel peptide in anti-allergic cosmetics

Method used

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  • Preparation method of mussel antiallergic peptide and application of mussel antiallergic peptide to cosmetics
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  • Preparation method of mussel antiallergic peptide and application of mussel antiallergic peptide to cosmetics

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preparation example Construction

[0040] In the first aspect, the present invention provides a method for preparing shellfish anti-allergic extract, the method comprising the following steps:

[0041] Step 1. Pretreatment: Cut open the shells of fresh and live shellfish with a knife, separate the shells and soft parts, take the useful part of the live shellfish, preferably the mantle part, and put it into the vitamin C aqueous solution to obtain fresh and live shellfish mixture.

[0042] The mass percent concentration of the vitamin C aqueous solution is 0.1-0.5%, preferably 0.2%. Adopting vitamin C aqueous solution is in order to prevent useful part from oxidizing; The mass ratio of the useful part of above-mentioned shellfish and vitamin C aqueous solution is 1: (1-2) (for example: can be 1:1, 1:1.2, 1:1.3, 1 :1.5, 1:1.8, 1:2), preferably 1:1.

[0043] The above-mentioned shellfish is preferably mussels, for example: thick-shelled mussels, blue mytilus; the place of origin of the shellfish is preferably Sh...

Embodiment 1

[0089] The preparation method of mussel antiallergic extract comprises the following steps:

[0090] (1) Mussel pretreatment: cut open the fresh mussel with a knife, separate the shell and the soft body part, and obtain the mantle part; and add it to the vitamin C aqueous solution with the same mass and a mass fraction of 0.2%, to obtain Mixture of fresh and live mussels.

[0091] (2) Homogenization treatment: the above mixed solution was stirred (homogenized) (8000rpm / 5min) to obtain a homogenate.

[0092] (3) Ultra-high pressure treatment: add an extraction solvent (aqueous solution of 0.02-0.05M phosphate buffer system) with a homogenate volume of 10 times the volume, soak for 3 hours, and put it into an ultra-high pressure extraction device (purchased from Tianjin Huatai Senmiao Bioengineering Technology Co., Ltd., model: L1-600 / 10) in the extraction container, under the condition of pressure of 600MPa, the extraction was carried out 5 times at room temperature, 25min eac...

Embodiment 2

[0100] The preparation method of mussel antiallergic extract, the equipment that adopts is identical with embodiment 1, comprises the following steps:

[0101] (1) Mussel pretreatment: cut open the fresh mussel with a knife, separate the shell and the soft body part, and obtain the mantle part; and add it to the vitamin C aqueous solution with the same mass and a mass fraction of 0.2%, to obtain Mixture of fresh and live mussels.

[0102] (2) Homogenization treatment: the above mixed solution was stirred (homogenized) (5000rpm / 5min) to obtain a homogenate.

[0103] (3) Ultra-high pressure treatment: add the extraction solvent (the aqueous solution of the phosphate buffer system of 0.02-0.05M) that the amount of homogenate is 10 times the volume, after soaking for 3 hours, put it into the extraction container of the ultra-high pressure extraction device, the pressure is Under the condition of 300MPa, extract 3 times at normal temperature, each time for 25min; wherein the 2nd-3...

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Abstract

The invention belongs to the field of marine biological component extraction, and relates to a preparation method of a mollusc antiallergic extract and application of the mollusc antiallergic extractto cosmetics, in particular to a preparation method of a mussel antiallergic peptide and application of the mussel antiallergic peptide to the cosmetics, and application of molluscs, especially the mussel antiallergic extract as an effective component to preparation of medicines, skin-care products or / and the cosmetics. The preparation method comprises the steps of pretreatment, homogenization, ultra-high-pressure extraction, subcritical extraction, enzymolysis and ultrafiltration, and can further comprise the steps of vacuum concentration and drying. A normal-temperature ultra-high-pressure technology and a subcritical extraction technology are combined to be applied to preparation of the mussel antiallergic extract, the produced extract can have the characteristics that the extraction efficiency is high, the component activity is high, chain scission is uniform, and the molecular weight can be controlled within 3KD, and the content of small peptides in mussels can reach upmost to 89.79%; and the mussel extract has the excellent antiallergic capacity and the high anti-oxidation effect.

Description

technical field [0001] The invention belongs to the field of extraction of marine biological components, and relates to a preparation method of shellfish anti-allergic extract and its application in cosmetics, in particular to a preparation method of mussel anti-allergic peptide and its application in cosmetics, especially to shellfish In particular, the mussel anti-allergic extract is used as an active ingredient in the preparation of medicines, skin care products or / and cosmetics. Background technique [0002] From a medical point of view, skin allergy mainly refers to when the skin is subjected to various external stimuli, such as adverse reactions of cosmetics, pollen, polluted air, chemical agents, etc., resulting in tingling, burning, itching and other symptoms on the skin, accompanied by Mild peeling, erythema, allergic dermatitis and other abnormalities. When the skin is allergic, the skin cells are damaged, and the skin cells with incomplete sebum membrane secretio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/00A61Q17/00A61P17/02
CPCA61K8/64A61K2800/75A61P17/02A61Q17/00A61Q19/005
Inventor 盘学平
Owner 广州市尚梓化工科技有限公司
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