Polymer fully-degradable vascular stent microscale 3D printing preparing method and device and application thereof

Abstract

The invention belongs to the technical fields of medical polymer fully-degradable vascular stents and micro-nano 3D printing, and particularly relates to a microscale 3D printing method and device forpolymer fully-degradable vascular stents and application of the device. A microscale 3D printing technology of using a single potential electric field to drive jetting is adopted, a biodegradable polymer thermoplastic material is used as a printing matrix material, a reinforcing phase material and drug powder are used as fillers, and required hollow, cylindrical and reticulated polymer fully-degradable vascular stents are printed on a cylindrical substrate, so that high-efficiency and low-cost manufacturing of the polymer fully-degradable vascular stents that can achieve precise control overthe degradation rate, the mechanical properties and the drug sustained-release and controlled-release performance can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medical polymer fully degradable vascular stents and micro-nano 3D printing, and specifically relates to a microscale 3D printing method, device and application of polymer fully degradable vascular stents. Background technique [0002] Cardiovascular disease is the number one killer of human death. According to statistics, nearly 1 / 3 of the global death toll comes from cardiovascular disease. In recent years, vascular stent implantation has developed into one of the most effective methods for the treatment of cardiovascular stenosis. Vascular stent implantation is to implant stents into the body to support blood vessels and compress intravascular plaques to prevent blood vessels from returning to normal. It is an interventional surgery in which elastic and intimal plaques protrude into blood vessels, and is widely used in coronary heart disease, cardiovascular, cerebrovascular, visceral blood vessels, per...

AI Technical Summary

Problems solved by technology

Due to the disordered and uncontrollable jet flow of the traditional electrospinning process, it is difficult to achieve a uniform and controllable pore structure of the vascular stent. At the same time, the sprayed jet is a filament with a diameter of nanometers, and the formed structure has poor mechanical properties. Defects; (2) Fused Deposition Forming: The speed of printing vascular stents by FDM technology is fast, and can realize the controllable adjustment of various vascular stent structures, shapes, porosity and other parameters, but the surface finish of the manufactured vascular stents is still poor, and The problem of being unable to achieve accurate printing, the traditional FDM process is difficult to control the precise extrusion of materials, which has a certain impact on the minimum molding size and printing accuracy of vascular stents (diameter 2-4mm, hollow, cylindrical, mesh structure), while radial support In terms of performance, the performance is weak. Printing complex mesh structures requires a large amount of support and is difficult to remove; (3) Laser cutting (engraving): the method commonly used to form vascular stents, mostly used for processing metal vascular stents, and femtosecond laser cutting is also reported Polylactic acid materials are used to manufacture vascular stents. Laser cutting has unavoidable problems such as heat-affected zones and insufficient surface quality, and subsequent cumbersome processing techniques are required, which increases the production cost of vascular stents and thus makes vascular stents expensive. ; (4) Thermally induced phase separation is easy to produce dense cortex and closed pores when preparing stents, resulting in uncontrollable and other adverse effects on the performance of stents; (5) Self-assembly is the spontaneous assembly of many similar individuals without external instructions. Combined to form a coherent and stable high-level structure, it is a technology in which basic structural units (molecules, nanomaterials, micron or larger scale substances) spontaneously form an ordered structure, which can realize nanofibers that are thinner than electrospinning (several Nano), higher manufacturing precision, but higher process complexity, involving more sophisticated manufacturing technology, high cost, low production efficiency

Therefore, these existing technologies are still difficult to meet the performance requirements of the ideal polymer fully degradable vascular stent, especially to achieve the matching of the degradability of the polymer fully degradable vascular stent and the drug sustained release (controllable drug release). challenge

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