High-strength polyvinyl alcohol gel and its preparation method and application
A polyvinyl alcohol gel and polyvinyl alcohol technology, applied in the fields of materials and biomaterials, can solve the problems of insufficient effectiveness, safety and quality controllability, the gel cannot meet cartilage implantation, excessive boron release, etc. Achieve the effect of ensuring biological safety, strengthening mechanical properties, and strong pressure resistance
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Embodiment 1
[0059] The preparation of embodiment 1 polyvinyl alcohol gel
[0060] The polyvinyl alcohol (PVA) used in this example was purchased from Aladdin Company, and its weight average molecular weight was 120 kDa, the molecular weight distribution was 1.5, and the alcoholysis degree was 99.4%.
[0061] 1 # polyvinyl alcohol gel
[0062] 1) Preparation of PVA aqueous solution: 25g of PVA was weighed into a 250mL three-necked flask, 100mL of purified water was added, the flask was placed in a 95°C water bath, heated and stirred until the PVA was completely dissolved to obtain an aqueous PVA solution. use;
[0063] 2) Chemical crosslinking: Weigh 15 g of PVA aqueous solution in a 100 mL beaker, add 1.5 mL of NaOH solution (15.0 wt.%) to the above PVA aqueous solution, stir evenly, then add 60 mg of BDDE, continue to stir evenly, Filled into the mold, and after sealing, the PVA sample was placed in a water bath at 25°C for chemical crosslinking for 24h;
[0064] 3) Physical cross-...
experiment example 1
[0090] Experimental Example 1 Unconfined compressive modulus of polyvinyl alcohol gel
[0091] 1 prepared in Example 1 of the present invention # polyvinyl alcohol gel, 2 # Polyvinyl alcohol gel, C1 prepared in the comparative example # PVA gel and C2 # Polyvinyl alcohol gel is a typical example, and the unconfined compressive modulus was detected by an electronic universal tensile machine of model UTM6202. details as follows:
[0092] The above sample was made into a cylindrical polyvinyl alcohol gel with a diameter of 0.85 cm and a height of 1 cm, and the unconfined compressive modulus was tested; testing conditions: compression speed 50 mm / min, maximum deformation 60%. 1 prepared in Example 1 # polyvinyl alcohol gel, 2# Polyvinyl alcohol gel, C1 prepared in the comparative example # PVA gel and C2 # The relationship between the stress and the compressive displacement of the three polyvinyl alcohol gels are as follows figure 1 , figure 2 , image 3 and Figure 4 ...
experiment example 2
[0098] Experimental Example 2 Unconfined cyclic compression of polyvinyl alcohol gel
[0099] 1 prepared in Example 1 of the present invention # Polyvinyl alcohol gel, C3 prepared in Comparative Example 2 # Polyvinyl alcohol gel is a typical example, and a UTM6202 electronic universal tensile machine is used to detect unconfined cyclic compression. details as follows:
[0100] The above sample was made into a cylindrical polyvinyl alcohol gel with a diameter of 0.85 cm and a height of 1 cm, and the unconfined compressive modulus was tested; testing conditions: compression speed 50 mm / min, maximum deformation amount 60%, cyclic compression 10 times, and observation of coagulation. Whether the glue will break. 1 prepared in Example 1 # Polyvinyl alcohol gel, C3 prepared in Comparative Example 1 # The results of the unconfined cycle compression test for both polyvinyl alcohol gels are listed in Table 2.
[0101] Table 2 Unconfined cycle compression test results of polyvinyl...
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