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Non-oxidation Ti3C2 quantum dots with function of selectively killing cancer cells, and preparation method and application of non-oxidation Ti3C2 quantum dots

A technology of quantum dots and cancer cells, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, titanium carbide, etc., can solve problems that have not been reported in the preparation, achieve inhibition and killing of cancer cells, and prepare The method is simple and convenient, and the effect of good biocompatibility

Active Publication Date: 2020-01-07
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ti involved in the above patent documents 3 C 2 Quantum dots will inevitably cause Ti 3 C 2 Oxidation of quantum dots
[0005] Currently, completely oxide-free Ti 3 C 2 The preparation of quantum dots has never been reported, and the prepared oxide-free Ti 3 C 2 Quantum dots have the property of selectively inhibiting and killing cancer cells

Method used

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  • Non-oxidation Ti3C2 quantum dots with function of selectively killing cancer cells, and preparation method and application of non-oxidation Ti3C2 quantum dots
  • Non-oxidation Ti3C2 quantum dots with function of selectively killing cancer cells, and preparation method and application of non-oxidation Ti3C2 quantum dots
  • Non-oxidation Ti3C2 quantum dots with function of selectively killing cancer cells, and preparation method and application of non-oxidation Ti3C2 quantum dots

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, raw material Ti 3 C 2 Preparation of (MXene)

[0048] First, add Ti to a Teflon beaker 3 AlC 2 (MAX phase) 10 parts, then slowly add 90 parts of hydrofluoric acid several times in small amounts, and after the addition, keep stirring for 3 days under the condition that the ambient temperature is 30° C. until the reaction is complete. Then, centrifugation and multiple washings were performed until the pH was close to 7. Then carry out vacuum drying treatment to obtain black Ti 3 C 2 Base powder.

[0049] Test the Ti that this embodiment obtains 3 C 2 SEM images of substrates, such as figure 1 shown. Depend on figure 1 It can be seen that Ti 3 C 2 The substrate size is on the micron scale.

Embodiment 2

[0050] Embodiment 2, "micro-explosion" method prepares Ti 3 C 2 quantum dot

[0051] 10 parts of two-dimensional material Ti 3 C 2 Place in a Teflon beaker, pour 50 parts of liquid nitrogen into the beaker and keep at room temperature for 3 minutes. During this process, liquid nitrogen will intercalate Ti 3 C 2 And accompanied by continuous evaporation. When the remaining amount of liquid nitrogen in the beaker is small, quickly add 50 parts of deionized water at 100°C. Since the boiling point of liquid nitrogen is -196°C, extreme temperature differences will be generated, resulting in 3 C 2 The liquid nitrogen in the interlayer will quickly vaporize, and a large amount of deionized water will form a water seal effect, making Ti 3 C 2 The microscopic accordion-like structure forms a closed space, which in turn triggers a "micro-explosion" to obtain an aqueous suspension. The entire process described above only takes a few minutes. (Note: If the residual amount of l...

Embodiment 3

[0057] Embodiment 3, " micro-explosion " method prepares Ti 3 C 2 quantum dot

[0058] 20 parts of two-dimensional material Ti 3 C 2 Place in a Teflon beaker, pour 50 parts of liquid nitrogen into the beaker and keep at room temperature for 2 minutes. During this process, liquid nitrogen will intercalate Ti 3 C 2 And accompanied by continuous evaporation. When the remaining amount of liquid nitrogen in the beaker is very small, quickly add 50 parts of deionized water at 90°C. Since the boiling point of liquid nitrogen is -196°C, extreme temperature differences will be generated, resulting in 3 C 2 The liquid nitrogen in the interlayer will quickly vaporize, and a large amount of deionized water will form a water seal effect, making Ti 3 C 2 The microscopic accordion-like structure forms a closed space, which in turn triggers a "micro-explosion" to obtain an aqueous suspension. The entire process described above only takes a few minutes. (Note: If the residual amoun...

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Abstract

The invention relates to non-oxidation Ti3C2 quantum dots with a function of selectively killing cancer cells, and a preparation method and an application of the non-oxidation Ti3C2 quantum dots. Theaverage size of the quantum dots is only about 7 nm, the quantum dots are completely free of oxidation and free of toxic elements such as heavy metals, and the quantum dots have broad-spectrum inhibiting and killing effects on the cancer cells and show excellent biocompatibility and extremely low cytotoxicity on normal stem cells of a human body. The non-oxidation Ti3C2 quantum dots provided by the invention have huge application potential in future anti-cancer and cancer-fighting roads. Meanwhile, the quantum dots have a rapid and spontaneous water dispersion characteristic. When an aqueous dispersion liquid is prepared, any ultrasonic and stirring treatment is not needed, so that the quantum dots are beneficial to direct application in biology or medicine.

Description

technical field [0001] The present invention relates to a kind of Ti 3 C 2 Quantum dots, on the basis of good biocompatibility to normal human stem cells, have the function of inhibiting and killing cancer cells, and belong to the field of nanotechnology. Background technique [0002] Cancer is a stubborn disease that has not been overcome by human beings so far, and its incidence rate is getting higher and higher, which has become a potential threat to people's life safety. As we all know, among the four major therapies of tumor surgery, radiotherapy, chemotherapy and biological therapy, chemotherapy is still the main treatment method, but the existing chemotherapy drugs have limited anti-tumor activity, have extremely serious side effects, and are expensive. Therefore, it is of great significance to explore drugs that have no toxic side effects and have good anti-tumor effects. This has become a new goal in the field of anti-tumor and has attracted widespread attention f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/921B82Y40/00A61K41/00A61P35/00
CPCC01B32/921B82Y40/00A61K41/0057A61P35/00C01P2004/64C01P2004/24
Inventor 陶绪堂李雪松
Owner SHANDONG UNIV
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