A kind of organelle-targeted aggregation-induced luminescent material and its preparation method

Abstract

A kind of organelle-targeted aggregation-induced luminescent material and its preparation method, the steps are: 1) using triphenylamine borate ester and aryl bromide compound as raw materials, fully and completely dissolved in toluene solution, adding potassium carbonate solution and Ethanol solvent, and with tetrakistriphenylphosphine palladium as the reaction catalyst, nitrogen reaction, after adding extraction, washing, solvent removal and column chromatography purification, the target material is obtained; when the aryl bromide compound in step 1 is 2,5 In the case of ‑dibromopyridine and 2,5‑dibromopyrazine, the product of step 1 and methyl iodide are used as raw materials, dissolved in toluene, heated for reaction, after removing the toluene solvent, adding sodium hexafluorophosphate and acetonitrile to make it fully dissolved, room temperature After stirring for 12-24 hours, after washing with water, removing the solvent under reduced pressure and recrystallization, the target fluorescent product can also be obtained; the preparation and purification cost of the present invention is low; it has excellent fluorescence emission performance and can realize multiple Organelle-specific targeted imaging performance studies.

Description

technical field [0001] The invention relates to the technical field of organic fluorescent materials and biological imaging thereof, in particular to a class of cell organelle-targeted aggregation-induced luminescent materials and a preparation method thereof. Background technique [0002] Compared with inorganic fluorescent materials, organic fluorescent materials usually have excellent luminescent properties and biocompatibility, and have shown good application prospects in biomedical fields such as cell imaging. At the same time, the good structural tunability of organic fluorescent materials can also provide the possibility to further meet their in-depth applications in the field of bioimaging. However, it is worth noting that for traditional organic fluorescent materials, although they can show good luminous efficiency and brightness in a single molecular state such as a solution, their luminous brightness usually falls short in an aggregated state such as a solid state...

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of poor luminescent performance of traditional organic fluorescent materials in the aggregated state, and to achieve specific targeted imaging in cells, the purpose of the present invention is to provide a class of organelle-targeted aggregation-induced luminescent materials and a preparation method thereof; In the solution state, the constructed aggregation-induced luminescent materials show more excellent fluorescence emission properties after forming aggregates; at the same time, this type of material also has better biocompatibility, and can be better applied to lipid droplets and mitochondria, etc. The specific targeted imaging of organelles provides a reliable method and approach for further dynamic observation of cell states and understanding of interactions between intracellular organelles, etc.

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