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Use of pitaya ovule extract to prepare composition for delaying skin aging

A technology of skin aging and red dragon fruit, applied in the field of plant extracts, can solve problems such as enzyme decomposition, complicated process, and risk of immune rejection

Inactive Publication Date: 2020-02-21
TCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen products currently available on the market are mainly required to directly supplement collagen. However, the molecular weight of collagen is large, and the application method can hardly make collagen penetrate the stratum corneum of the skin to reach the dermis where it acts; if it is injected directly Collagen supplementation can immediately reduce the fine lines of the skin, but the collagen injected into the body is easily decomposed by the enzymes in the body, and regular injections are required, the process is complicated and the cost is high, and the immune rejection reaction that may be caused by collagen injection more risk
If collagen is supplemented by eating foods rich in collagen, since protein enters the gastrointestinal tract and is digested into small molecular polypeptides or amino acids, the body will certainly use these amino acids to synthesize proteins, but not limited to collagen, therefore, Collagen supplementation through dietary methods has limited effect

Method used

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  • Use of pitaya ovule extract to prepare composition for delaying skin aging
  • Use of pitaya ovule extract to prepare composition for delaying skin aging
  • Use of pitaya ovule extract to prepare composition for delaying skin aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of Red Dragon Fruit Ovule Extract

[0031] Red dragon fruit, also known as dragon fruit or cactus fruit, is a plant of the genus Trigonum in the family Cactaceae. It is native to Central America and is now widely planted in Taiwan, China. The fruit of this plant is rich in dietary fiber and can stimulate gastrointestinal peristalsis, which can be used to prevent constipation.

Embodiment 2

[0035] Red dragon fruit ovule extract promotes collagen secretion

[0036] In order to test the influence of the red dragon fruit ovule extract of the present invention on the collagen production of skin cells, the present embodiment measures human skin fibroblast CCD-966SK through the red dragon fruit ovule extract described in Example 1 with a collagen secretion test Changes in collagen production after treatment. Briefly, CCD-966SK cells were divided into 2×10 4 Cells / well were seeded in 24-well plates, and each well contained 500 μL of cell culture medium. After culturing the cells at 37°C for 24 hours, the cell culture medium was removed and the cells were washed with PBS solution. Secondly, add 500 μL of 8 mg / mL red dragon fruit ovule extract and 500 μL of FBS-free cell culture medium to each well of cells (experimental group), and treat the cells with 500 μL of FBS-free cell culture medium as a blank control group . After the aforementioned two groups of cells were ...

Embodiment 3

[0039] Red dragon fruit ovule extract promotes skin fibroblast proliferation

[0040] In order to test whether the red dragon fruit ovule extract of the present invention promotes the proliferation of human skin fibroblasts, this example uses a cell proliferation test to measure the proliferation status of CCD-966SK cells after being treated with the red dragon fruit ovule extract described in Example 1. Briefly, CCD-966SK cells were seeded in 96-well plates at 3000 cells / well, and each well contained 0.1 mM non-essential amino acids, 1.5 g / L sodium bicarbonate, 1 mM sodium pyruvate, and 10% FBS MEM medium. After culturing the cells at 37°C for 2 hours, remove the medium, and treat the cells in each well in the following manner: (a) apply 100 μL of the aforementioned medium without FBS (blank control group); (b) apply 100 μL containing 20 The aforementioned culture medium with %FBS (positive control group); or (c) 100 μL of the aforementioned culture medium without FBS but ad...

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Abstract

The invention relates to the use of a plant extract, in particular to the use of a pitaya ovule extract to prepare a composition for delaying skin aging. The pitaya ovule extract is preferably prepared by extracting a pitaya ovules with water as a solvent, can promote the secretion of collagen by promoting the proliferation of skin fibroblasts, and can also reduce the end product of collagen saccharification and therefore helps to maintain the youthful state of the skin.

Description

technical field [0001] The present invention relates to the use of a plant extract, in particular to the use of a red dragon fruit ovule extract for preparing a composition for delaying skin aging. Background technique [0002] Collagen is the protein with the most content in mammals, accounting for about one-third of the total protein in the human body, and widely exists in the skin, cartilage, cornea, blood vessel walls, and internal organs of the human body. It mainly exists in the extracellular matrix of connective tissue and can provide the mechanical support and strength required by connective tissue. Collagen in the human body can be divided into different types due to differences in the composition of polypeptides. Among them, the most related to skin structure are type 1, type 3, and type 4 collagen. The dermis contains fibrous type I and type III collagens, and the non-fibrous basement membrane beneath the epithelium contains type IV collagens. Current studies ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/33A61P17/18A23L33/105
CPCA61K36/33A61P17/18A23L33/105A23V2002/00A61K2236/331A23L2/38A23V2250/21A23V2200/318
Inventor 林咏翔李姿仪
Owner TCI CO LTD