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Micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition for improving skin aging and sensitivity and application of micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition

A technology of sodium hyaluronate and skin improvement, applied in food science and other fields

Pending Publication Date: 2022-04-08
北京姿美堂生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report on the appropriate molecular weight of sodium hyaluronate that can effectively improve skin moisture by oral administration

Method used

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  • Micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition for improving skin aging and sensitivity and application of micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition
  • Micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition for improving skin aging and sensitivity and application of micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition
  • Micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition for improving skin aging and sensitivity and application of micromolecular sodium hyaluronate and micromolecular sodium hyaluronate composition

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preparation example Construction

[0026] In the present invention, small molecule sodium hyaluronate is a mixture of small molecule sodium hyaluronate obtained after hydrolysis of sodium hyaluronate with an average molecular weight distribution in the range of 80KDa to 800KDa, preferably prepared by the following steps: hyaluronic acid The sodium solid is hydrolyzed for 5-15 hours under the condition of hydrogen peroxide.

[0027] The present invention has no special limitation on the source of the sodium hyaluronate solid, and the source of the sodium hyaluronate solid well known in the art can be used. In the embodiment of the present invention, the average molecular weight of the sodium hyaluronate solid is preferably 0.1-1 MDa; the purity of the sodium hyaluronate solid is preferably ≥99%. The preparation method of the sodium hyaluronate solid preferably comprises the following steps:

[0028] (a) inoculating yeast in a liquid medium for fermentation and culturing to obtain a fermentation broth;

[0029]...

Embodiment 1

[0046] Preparation method of small molecule sodium hyaluronate

[0047] (a) Fermentation: using yeast as the strain, first take the slant strain and inoculate it on the seed medium, and cultivate it at 37° C. for 20 hours to obtain the yeast liquid;

[0048] (b) Inoculate the obtained yeast liquid into the liquid medium of the fermenter, the volume ratio of the bacterial liquid to the medium is 1:8, the ventilation rate is 0.8vvm, the stirring speed is 250rpm, the culture temperature is 37°C, and the fermentation time is 60h, obtain fermented liquid;

[0049] (c) Separation: After the fermentation broth is adsorbed by 300-mesh activated carbon, 80% ethanol is added for precipitation, and the crude sodium hyaluronate is obtained by filtration;

[0050] (d) Refining: the crude sodium hyaluronate is washed with 80% ethanol, heated and dried to obtain 99% sodium hyaluronate;

[0051] (e) Hydrolysis: hydrolyze the solid sodium hyaluronate with an average molecular weight of 0.1MD...

Embodiment 2

[0055] The small molecule sodium hyaluronate hydrolyzate was prepared according to the method of Example 1, the only difference being that the hydrolysis time was set at 8h and 9h respectively. The average molecular weight of the hydrolyzed sodium hyaluronate was measured according to the method of Example 1. The results show that the average molecular weight of the water molecule sodium hyaluronate prepared by the method is 200KDa-400KDa.

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Abstract

The invention provides micromolecular sodium hyaluronate and a micromolecular sodium hyaluronate composition for improving skin aging and sensitivity and application of the micromolecular sodium hyaluronate and the micromolecular sodium hyaluronate composition, and belongs to the technical field of health food. The micromolecular sodium hyaluronate with the average molecular weight of 80KDa-800KDa has the effect of remarkably improving the water content of the skin, and the collagen peptide and the micromolecular sodium hyaluronate are micromolecules and can be easily absorbed by a human body. The composition composed of collagen peptide hydrolysate, micromolecular sodium hyaluronate hydrolysate, elastin, cubilose powder, mangosteen powder, salmon nose cartilage powder, purple chrysanthemum flower powder, astaxanthin, tremella polysaccharide, vitamin C and concentrated fruit juice can improve skin aging and restore skin elasticity, and has the effects of whitening skin and whitening skin. The skin moisture content is increased, the skin moisture evaporation amount is reduced, the pre-collagen secretion amount is increased, the collagen biosynthesis is promoted, and the skin redness and sensitive symptoms are relieved.

Description

technical field [0001] The invention belongs to the technical field of health food, and in particular relates to a small molecule sodium hyaluronate composition for improving skin aging and sensitivity and application thereof. Background technique [0002] In recent years, due to the development of medical technology, the average life span of human beings has been extended, and with the improvement of the quality of life and the improvement of yearning for a healthy and beautiful life, attention to skin beauty and health is increasing. Therefore, in order to maintain healthy skin, various cosmetic functional cosmetics have been developed, and researches on preventing, alleviating and improving the formation of skin wrinkles are being actively carried out. In addition, there are limitations in the fact that cosmetic ingredients reach the dermis of the skin to supply nutrients, and with changes in the understanding that nutritional ingredients or functional ingredients are sup...

Claims

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Application Information

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IPC IPC(8): A23L33/125A23L33/18A23L33/17A23L33/10A23L33/15
Inventor 宫建辉徐熙明徐宇明
Owner 北京姿美堂生物技术股份有限公司
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