Synthetic method of mineralized sendai virus-based tumor combined treatment nano preparation

A technology of combined therapy and nano-preparation, applied in anti-tumor drugs, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of cumbersome process, harsh environmental requirements, pollution, etc. significant effect
CN110833566AInactive Publication Date: 2020-02-25TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2020-02-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthetic method of a mineralized sendai virus-based tumor combined treatment nano preparation, the method is used for synthesizing the photo-thermal tumor combined treatmentnano preparation through bionic simulation of a strategy of mineralizing sendai virus and ICG ((ICG + SEV) coated CaHPO4) by CaHPO4. The method comprises the following specific steps: 1) preparing anindocyanine green aqueous solution; and 2) synthesizing (ICG + SEV) coated CaHPO4 nano particles by a one-pot method. The sendai virus (SEV) can activate the immune function of the body in a whole body mode, and all-around killing and removing of tumors are achieved. The ICG has high photo-thermal conversion efficiency under near-infrared laser irradiation, and tumor photo-thermal treatment can be efficiently guided. The pro-apoptotic protease which promote each other and cause and cause each other exist in a pathway formed by calcium ion signals and tumor cell apoptosis, so that tumor cell apoptosis is accelerated. The composite nanoparticle integrating virus immunotherapy and photothermal therapy can improve the tumor treatment effect.
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Description

technical field

[0001] The invention belongs to the field of preparation of nano preparations, in particular to a method for synthesizing nano preparations for combined treatment of tumors based on mineralized Sendai virus, CaHPO 4 Strategies for Mineralization of Sendai Virus and ICG Biomimetic Synthesis of Nanoformulations for Combination Photothermal Tumor Therapy. Background technique

[0002] At present, tumor is one of the most threatening diseases to human beings in the world. Immunotherapy can treat cancer by activating the human immune system and relying on its own immune function to kill cancer cells and tumor tissues. Therefore, immunotherapy is one of the most effective ways to treat tumors. In view of the fact that the inactivated Sendai virus (SEV) can be used as a foreign body in the body, it can stimulate the systemic immune system to produce a cytokine storm (such as interferon, tumor necrosis factor and various interleukins, etc.), and it has an important...

Claims

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