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Fluorine surfactant as well as preparation method and application thereof

A technology of fluorosurfactants and surfactants, applied in the field of fluorosurfactants and their preparation, can solve the problems of unstable small molecular substances, cumbersome preparation methods of copolymers, and incomplete removal of impurities, so as to reduce the droplet Effects of surface tension, ensuring stability, and simple synthesis method

Active Publication Date: 2020-02-28
GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, non-ionic copolymers such as perfluoropolyether polymers are mainly used as system surfactants in micro-droplet microfluidic systems of perfluoroemulsion systems. These surfactants can be used to produce droplets with good biocompatibility. Among them, the structure of these surfactants is mostly three-stage, but the preparation method of this type of copolymer reported at present is cumbersome and difficult to synthesize, which is not conducive to production, and it is easy to remove impurities incompletely and produce unstable small molecular substances. Under some special conditions, PCR must avoid the interference of other impurities, which limits its use

Method used

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  • Fluorine surfactant as well as preparation method and application thereof
  • Fluorine surfactant as well as preparation method and application thereof
  • Fluorine surfactant as well as preparation method and application thereof

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preparation example Construction

[0044] The present invention also provides a kind of preparation method of above-mentioned fluorosurfactant, comprises the following steps:

[0045] (1) Preparation of the intermediate: Dissolve the fluorine-containing polyether with the structure of formula III and the oxalyl chloride with the structure of formula IV in a solvent, and remove the solvent after heating for 6h to 12h to obtain the intermediate with the structure of formula V;

[0046]

[0047] (2) Synthesis of fluorosurfactant: add Tween 20 of formula VI structure and mixed solvent to the intermediate of formula V structure, heat and stir to obtain the compound of formula I structure;

[0048]

[0049] In the preparation method provided by the present invention, the fluorosurfactant can be directly reacted without using a catalyst, and what is prepared is a non-existing three-stage fluorosurfactant, the preparation method is simple, and the preparation process is simplified. route.

[0050] In a specific ...

Embodiment 1

[0062] A kind of fluorosurfactant, molecular formula is [C 3 f 7 O(C 3 f 6 O) n CO] m C 26 h 60-m o 10 , wherein, n=32-40, m=3, obtain by following preparation method:

[0063] Weigh 60g of fluorine-containing polyether and dissolve in 500mL of HFE7100, add 100mL of oxalyl chloride, heat to reflux and stir for 16h, and then remove the solvent under reduced pressure. Add 3.6g of Tween 20, 100mL of HFE7100, and 20mL of tetrahydrofuran, heat to reflux and stir for 24h, filter the reaction solution, add 100mL of absolute ethanol while stirring, remove the viscous material in the lower layer, and dry it in vacuo.

Embodiment 2

[0065] A kind of fluorosurfactant, molecular formula is [C 3 f 7 O(C 3 f 6 O) n CO] m C 26 h 60-m o 10 , wherein, n=32-40, m=2, obtain by following preparation method:

[0066] Weigh 60g of fluorine-containing polyether and dissolve in 500mL of HFE7100, add 100mL of oxalyl chloride, heat to reflux and stir for 16h, and then remove the solvent under reduced pressure. Add 5.4g of Tween 20, 100mL of HFE7100, 20mL of tetrahydrofuran, heat to reflux and stir for 24h, filter the reaction solution, add 100mL of absolute ethanol while stirring, remove the viscous material in the lower layer, and dry it in vacuo.

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Abstract

The invention relates to a fluorine surfactant as well as a preparation method and application thereof, and belongs to the technical field of surfactants. The fluorine surfactant has the characteristics of a structure shown as formula I, has good surface activity, can remarkably reduce the surface tension of liquid drops, and can be used in a PCR microfluidic system to ensure the stability of generated liquid drops; and the raw materials adopted in the preparation method of the fluorine surfactant are cheap and easy to obtain, and the synthesis method is simple.

Description

technical field [0001] The invention relates to the field of surfactants, in particular to a fluorosurfactant and its preparation method and application. Background technique [0002] All or part of the hydrogen atoms in the hydrocarbon chain in the ordinary surfactant molecule are replaced by fluorine atoms, which are called fluorosurfactants, also called fluorocarbon surfactants, fluorocarbon surfactants, fluorine-containing surfactants, etc. Fluorosurfactant is one of the most important special surfactants. They have special properties unmatched by ordinary surfactants, such as high surface activity, high thermal stability, high chemical stability and hydrophobic and oil-repellent, that is, "three high ", "Amphophobia", it can resist the action of strong oxidants, strong acids and strong bases, and can still maintain good surface activity in these solutions, so it can be used in solutions under some extreme conditions. [0003] Polymerase chain reaction (Polymer Chain Re...

Claims

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Application Information

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IPC IPC(8): C08G65/331B01L3/00
CPCC08G65/3318B01L3/5027B01L2300/12B01L2200/10
Inventor 王瑞彬
Owner GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST