Microacupuncture needle paster for improving skin hyperplastic scars and preparation method of microacupuncture needle paster

A technology for hypertrophic scars and skin improvement, applied in the field of medical beauty, which can solve the problems of poor convenience, poor privacy, and high cost

Active Publication Date: 2020-03-31
广州新济薇娜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the effect is good, it requires professional doctors or practitioners to perform the operation and nursing first, which is not convenient, privacy is poor, and the cost is high, and the operation has certain risks, there are risks of infection and various complications, and it does not have high popularity. Rate

Method used

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  • Microacupuncture needle paster for improving skin hyperplastic scars and preparation method of microacupuncture needle paster
  • Microacupuncture needle paster for improving skin hyperplastic scars and preparation method of microacupuncture needle paster
  • Microacupuncture needle paster for improving skin hyperplastic scars and preparation method of microacupuncture needle paster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The active substance in the microneedle array 10 in the microneedle patch for improving skin hypertrophic scars described in this example is prepared from the following components: small molecule sodium hyaluronate (molecular weight 1KD-10kD, manufacturer source: Bloomage Biotechnology Technology Co., Ltd., the same below) 20 parts, 64 parts of water, 5 parts of PVP, 8 parts of steroids, 1.5 parts of panthenol, 1 part of asiaticoside, 0.5 part of fibroblast growth factor; the reinforcing fiber 22 adopts square mesh cotton fiber;

[0044] The silicone gel base 21 is prepared from the following components: 48 parts of polydimethylsiloxane, 36 parts of dimethyl silicone oil, 4 parts of amyl glycol, 3 parts of horse fat, and 3 parts of snake oil , 5 parts of stearyl alcohol, 1 part of PEG-7 hydrogenated ricinoleic acid;

[0045] The non-woven fabric 31 is a unidirectional elastic non-woven fabric 31, and the aqueous gel 32 is prepared from the following components: 45 part...

Embodiment 2

[0052] The active substance in the microneedle array 10 in the microneedle patch for improving skin hypertrophic scars described in this example consists of the following components: 18 parts of small molecule sodium hyaluronate, 62 parts of water, 5 parts of PVP, 10 parts of steroids, 2 parts of panthenol, 2.5 parts of asiaticoside, 0.5 part of fibroblast growth factor;

[0053] The reinforcing fiber 22 adopts polyester fiber with square mesh; the silicone gel base block 21 is composed of the following components: 52 parts of polydimethylsiloxane, 32 parts of dimethyl silicone oil, 4 parts of amyl glycol, 2 parts horse fat, 3 parts snake oil, 5 parts stearyl alcohol, 2 parts PEG-7 hydrogenated ricinoleic acid;

[0054] Non-woven fabric 31 adopts unidirectional elastic non-woven fabric 31, and water-based gel 32 is composed of the following components: 50 parts of water, 35 parts of glycerin, 5.5 parts of sodium polyacrylate, 6 parts of carrageenan, sodium carboxymethyl cellul...

Embodiment 3

[0060] Method: Purchase 22 big-eared white rabbits, male or female, with a body weight of 1.8-2.2kg. After 7 days of adaptive feeding, observe each white rabbit, eat water, and have no obvious abnormalities. They are included in the experiment. Establishment of scar animal model: Inject pentobarbital solution with a concentration of 30 g / L into the ear margin for anesthesia, and make a circular wound with a diameter of 1 cm on the ventral side of the rabbit ear along the long axis, 2 places in each ear, with an interval of about 3.0 cm, The full-thickness skin was completely removed, and the wound healed naturally after 21 days of skin transformation to form a hypertrophic scar mass. There was no unhealed wound infection or poor healing, and no new scar tissue was formed.

[0061] Grouping: 15 rabbits were selected and randomly divided into blank group, positive control group, Example 1 group (using the microneedle patch described in Example 1), and Example 2 group (using the ...

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Abstract

The invention discloses a microacupuncture needle paster for improving skin hyperplastic scars. The microacupuncture needle paster comprises a microacupuncture needle array loaded with active constitutents, a fixed connecting layer and a hydrogel layer, wherein the microacupuncture needle array is located on the first surface of the fixed connecting layer; the hydrogel layer is arranged on the second surface of the fixed connecting layer; the fixed connecting layer is located between the microacupuncture needle array and the hydrogel layer; a plurality of infiltration channels are formed in the fixed connecting layer, penetrate through the fixed connecting layer, and communicate with the microacupuncture needle array and the hydrogel layer; the fixed connecting layer comprises a silicone gel matrix and strengthening fibers; the strengthening fibers are connected with the silicone gel matrix and are used for supporting the silicone gel matrix; and the infiltration channels are formed inthe silicone gel matrix. According to the microacupuncture needle paster for improving the skin hyperplastic scars disclosed by the invention, the wound ulceration period can be accelerated and improved, the risk of forming hyperplastic scars during wound healing can be reduced, and local state blemish in skin after the hyperplastic scars are formed can also be improved.

Description

technical field [0001] The invention relates to the technical field of medical cosmetology, in particular to a microneedle patch for improving skin hypertrophic scars and a preparation method thereof. Background technique [0002] Hypertrophic scar is a common skin symptom that affects the appearance. Its source is mainly formed after surgery, skin trauma, inflammation, etc., and it is one of the common scars. The common scar removal methods are mainly divided into two categories, including non-invasive and traumatic scar removal methods. Non-invasive types include massage scar removal therapy, film pressing scar removal method, and silicon compression scar removal therapy. Temporal topical scar tissue massage softens hard scars and improves raised or contracture-prone scars. The film pressing scar removal method is to stick the film on the scar, press vertically and firmly at fixed points, so that the scar will gradually improve, and for large-area wounds, it is a compress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K8/9789A61K8/92A61K8/73A61K8/64A61K8/63A61K8/42A61Q19/00
CPCA61K8/42A61K8/63A61K8/64A61K8/735A61K8/925A61K2800/91A61M37/0015A61M2037/0023A61M2037/0053A61Q19/00A61K8/9789
Inventor 温新国张敏敏陈航平杨思超任春艳
Owner 广州新济薇娜生物科技有限公司
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