Gallocatechin and gallocatechin in preparing intestinal pathogenic bacterium medicine and feed additive

Abstract

The invention discloses gallocatechin and gallocatechin in preparing an intestinal pathogenic bacterium medicine and a feed additive. The intestinal pathogenic bacterium medicine and the feed additivewhich are prepared from the gallocatechin as a raw material are derivatives prepared by taking the gallocatechin as a framework, and targeted intestinal pathogenic bacteria are enterotoxin productionescherichia coli K88, K99 and 987P. Research of multiple methods verifies that the gallocatechin has a very good antibacterial effect on intestinal pathogenic bacteria; and at a cell level, the gallocatechin is verified as being nontoxic, odor-free, nonirritant for bodies and free of mutagenesis, carcinogenesis or teratogenesis. As a natural extract, the gallocatechin is widely applied to aspectsof natural food preservatives, makes a security basis for animal use, provides candidate substances for development of novel anti-intestinal pathogenic bacterium medicines and substitutes of antibiotics and has very good application prospects in prevention and treatment on intestinal pathogenic bacteria.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to gallocatechin and its application in the preparation of intestinal pathogenic bacteria medicine and feed additive. Background technique [0002] Piglet colibacillosis is the most common type of intestinal infectious disease in newborn piglets, mainly including newborn piglet diarrhea (commonly known as piglet yellow and white scour), weaned piglet diarrhea or edema disease, etc. It can occur in piglets from a few hours after birth to one week old, and it is more common in 1-3 days old. It is characterized by severe diarrhea, discharge of yellow or yellow-white serous feces, and rapid dehydration death. Most cases have no vomiting. and the mortality rate is extremely high; the prevalence of the disease has no obvious seasonality; the prevalence of the disease is wide, and it has been reported in different parts of the world, which has brought serious harm to pig produc...

AI Technical Summary

Problems solved by technology

[0006] The technical problem solved by the present invention is to overcome the disadvantages of the prior art that the prevention and control effect of piglet Escherichia coli is poor, and the serotype of the pathogenic bacteria does not match the serotype of the vaccine, and provides a kind of gallocatechin and its role in the preparation of intestinal pathogenic bacteria drugs and feed additives.

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